What is it?

The HLA-DQ2.2, HLA-DQ2.5, and HLA-DQ8 are specific variants (alleles) of the human leukocyte antigen (HLA) system, which is part of the immune system. These particular HLA types are strongly associated with celiac disease, an autoimmune disorder where ingestion of gluten leads to damage in the small intestine.

1. HLA-DQ2.2: This allele is one of the variants associated with an increased risk of celiac disease, although it confers a lower risk compared to HLA-DQ2.5. Individuals with this allele may develop celiac disease, but it is less common.

2. HLA-DQ2.5: This is the most common and most strongly associated allele with celiac disease. About 90-95% of people with celiac disease carry HLA-DQ2.5. It significantly increases the risk of developing the disease when exposed to gluten.

3. HLA-DQ8: This allele is also associated with celiac disease, but less frequently than HLA-DQ2.5. It is found in about 5-10% of individuals with celiac disease, and those who carry it still have a risk of developing the disease when exposed to gluten.

These HLA variants are important markers used in the genetic testing for celiac disease risk. However, carrying one of these alleles does not guarantee that a person will develop celiac disease; it simply indicates a genetic predisposition.

Benefits

The Process

Why Choose London Blood Tests?

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How to Get Started

Understanding your genetic risk for coeliac disease can significantly enhance your quality of life by allowing you to make informed dietary choices. At London Blood Tests, we offer a quick, reliable, and convenient way to diagnose genetic predispositions to coeliac disease. Book your test today and take the first step towards better health management.