1,25-dihydroxyvitamin D (Calcitriol)
This test measures 1,25-dihydroxyvitamin D, the biologically active form of vitamin D. It is used to investigate calcium imbalance, kidney disease and...
Activated Protein C Resistance
140.00
This test assesses how well activated protein C regulates blood clotting. It is used to identify inherited clotting disorders associated with increased thrombosis risk.
Turnaround time
4 days
Biomarkers count
1
Same-Day Appointments
UKAS Accredited Labs
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Under 18? Patients under 18 can only be seen at GB Medlabs and Clinilabs, Monday to Friday only.
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Details about Activated Protein C Resistance
What is the Activated Protein C Resistance Test?
The Activated Protein C (APC) Resistance test evaluates how effectively activated protein C controls blood clot formation. Activated protein C is a natural anticoagulant that slows clotting by inactivating clotting factors V and VIII. When resistance is present, clotting activity increases, raising the risk of abnormal blood clots.
The most common cause of APC resistance is the Factor V Leiden mutation, a genetic change that makes factor V less responsive to regulation by activated protein C. This results in a hypercoagulable state, meaning the blood has a higher tendency to clot than normal.
This test is widely used as a functional screening tool for inherited thrombophilia, particularly when there is a personal or family history of unexplained clotting events.
Why do I need a test for Activated Protein C Resistance?
You may need this test if you have experienced unexplained blood clots, recurrent miscarriages, or if there is a family history of thrombosis. APC resistance is one of the most common inherited risk factors for venous thromboembolism and can significantly increase clotting risk, especially when combined with other factors.
Testing is also recommended before prescribing oestrogen-containing medications, during fertility investigations, or when clotting occurs at a young age or in unusual locations. Identifying APC resistance helps guide prevention strategies and long-term management.
Symptoms and scenarios where testing is recommended:
- Deep vein thrombosis (DVT)
- Pulmonary embolism (PE)
- Blood clots at a young age
- Recurrent pregnancy loss
- Family history of thrombosis
- Clotting after surgery or immobilisation
- Thrombosis without obvious trigger
- Pre-treatment assessment before hormone therapy
Benefits of the Activated Protein C Resistance Test
- Identifies inherited clotting risk early
Detects functional resistance associated with Factor V Leiden mutation. - Helps explain unexplained thrombosis
Provides insight into clotting events without clear external cause. - Guides personalised prevention strategies
Supports decisions around anticoagulation, lifestyle and medication use. - Useful in fertility and pregnancy assessment
Identifies clotting risks linked to miscarriage and pregnancy complications. - Supports safe prescribing of hormone therapy
Helps assess clotting risk before oestrogen-based treatments. - Reduces risk of recurrent clotting events
Enables proactive risk management once identified. - Complements genetic testing
Functional testing can be followed by confirmatory genetic analysis. - Simple and clinically powerful test
Requires only a standard blood sample.
Step-by-Step: How Testing Works
Choose your preferred testing method
You can attend one of our UK partner clinics or arrange a home or hotel visit with a mobile phlebotomist.
Option 1 – In-Clinic Blood Draw
- Select your nearest UK clinic and book an appointment.
- A clinician or phlebotomist collects a venous blood sample.
- The sample is analysed for activated protein C response.
- Results are delivered securely online.
Option 2 – Home or Hotel Phlebotomy (+£60)
- Book a UK-wide home or hotel visit at a convenient time.
- A trained phlebotomist collects your blood sample on-site.
- The sample is packaged and transported to the laboratory.
- Results are uploaded digitally without the need to travel.
Access your report
You can download and share your results with your GP, haematologist or fertility specialist if required.
Your Results Explained
Low / Reduced Response (Resistance Present)
Reduced response indicates activated protein C resistance.
This suggests an increased risk of venous thrombosis, commonly associated with Factor V Leiden mutation.
Further genetic testing may be recommended to confirm the underlying cause.
Normal Response
A normal result means activated protein C is functioning correctly.
This indicates no evidence of APC resistance at the time of testing.
High Sensitivity / Enhanced Response
Enhanced response is uncommon and generally not clinically significant.
Results should always be interpreted alongside clinical history and other clotting tests.
How It Works
Simple steps to get your results
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Book Online
Choose your test online and book in seconds. Select your preferred clinic location or home visit option.
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Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
3
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
Take control of your health with London Blood Tests
WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.
Frequently Asked Questions
APC resistance is usually caused by Factor V Leiden, but genetic testing confirms it.
Yes, it is commonly inherited in an autosomal dominant pattern.
No, many people remain asymptomatic, but risk is increased.
Yes, especially in cases of miscarriage or clotting history.
Some anticoagulants can affect results; clinical guidance may be required.
Yes, combined risk is significantly higher.
No fasting is required.
Yes, especially with strong family history.
No, other thrombophilias may still be present.
Further assessment, possible genetic testing and personalised risk management may be advised.
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