At London Blood Tests, the EndoInsight Panel offers an in-depth evaluation of your hormonal balance, adrenal function, metabolic activity and potential toxin exposure. Using a simple urine collection, this advanced assessment measures a wide spectrum of sex hormones, adrenal steroids, metabolites, endocrine disruptors, melatonin, and key organic acids to provide a clear picture of your overall endocrine and metabolic health.

This test is ideal for individuals experiencing:

Fatigue or low energy
Mood changes or anxiety
Fertility or menstrual concerns
Perimenopause or menopause symptoms
Weight fluctuations
Sleep disturbance
Suspected toxin-related hormonal disruption
Chronic stress or adrenal imbalance

Using highly sensitive LC-MS/MS technology, EndoInsight delivers accurate, reliable, and clinically meaningful data to support personalised treatment plans.

What the EndoInsight Panel Measures

1. Estrogens & Metabolites

A comprehensive breakdown of oestrogen production, detoxification, and metabolism pathways.

Markers measured:

Estrone (E1)
Estradiol (E2)
Estriol (E3)
E3/(E1+E2)
2-OH Estradiol
2-OH Estrone
4-OH Estrone
16-OH Estrone
2-OH (E1+E2)/16-OH E1
2-MeOH Estradiol
2-MeOH Estrone
2-MeOH E1/2-OH E1
4-MeOH Estradiol
4-MeOH Estrone
4-MeOH E1/4-OH E1
4-MeOH E2/4-OH E2

These markers help assess oestrogen dominance, detoxification issues, PMS symptoms, menopause changes, and hormone-related mood disorders.

2. Progesterone & Metabolites

Evaluates progesterone production and downstream metabolites linked to mood, fertility, perimenopause and stress response.

Markers measured:

Pregnanediol (5 β-pregnane-3a-diol)
Progesterone
Allopregnanolone
Allopregnanediol
3a-Dihydroprogesterone
20a-Dihydroprogesterone
Deoxycorticosterone
Corticosterone
Pgdiol/E2 Ratio

These markers offer insight into cycle balance, low progesterone symptoms, anxiety, and luteal phase function.

3. Primary Androgens

Assesses androgen production, metabolism and balance.

Markers measured:

DHEA
DHEAS
Androstenedione
Androsterone
Etiocholanolone
Testosterone
Epi-Testosterone
T/Epi-T Ratio
5a-DHT
5a,3a-Androstanediol

Useful for evaluating PCOS, libido concerns, fatigue, and metabolic and adrenal performance.

4. Endocrine Disruptors

Screens for environmental chemicals known to interfere with hormonal pathways.

Markers measured:

Bisphenol A (BPA)
PFAS (Polyfluoroalkyl Substances)
PFOA (Perfluorooctanoic Acid)
PFOS (Perfluorooctane Sulphonic Acid)
Lead (Pb)
Mercury (Hg)
Cadmium (Cd)
Arsenic (As)
Aluminum (Al)
Chromium (Cr6+)
Nickel (Ni)

These results are highly valuable for individuals with unexplained hormonal symptoms, chronic fatigue or detoxification issues.

5. Glucocorticoids (Adrenal Steroids)

Provides a full picture of adrenal output across the day.

Markers measured:

Total Cortisol
Total Cortisone
Cortisol/Cortisone Ratio
Tetrahydrocortisol
Tetrahydrocortisone

This section highlights adrenal stress, burnout, inflammation patterns, and HPA-axis imbalance.

6. Free Cortisol (Diurnal Adrenal Rhythm)

Evaluates free, bioavailable cortisol at key points throughout the day.

Markers:

Morning
Midday
Afternoon
Evening

This shows whether your adrenal rhythm is healthy, flat, or overly stressed.

7. Free Cortisone

A second adrenal pathway offering additional insight into stress hormone conversion.

Markers:

Morning
Midday
Afternoon
Evening

8. Free Melatonin

Assesses melatonin secretion patterns linked to sleep quality, circadian rhythm and recovery.

Markers:

Morning
Midday
Afternoon
Evening

9. Creatinine

Used for normalising results and assessing hydration status.

Markers:

Pooled
Morning
Midday
Afternoon
Evening

10. Key Organic Acids

Essential metabolic markers linked to nutrient status, neurotransmitters, gut function and oxidative stress.

Markers measured:

Methylmalonate
Xanthurenate
Kynurenate
β-hydroxyisovalerate
Pyroglutamate
Indican
Homovanillate
Vanilmandelate
Quinolinate
8-OHdG (oxidative stress marker)

These markers help identify vitamin deficiencies, mitochondrial fatigue, inflammation, and overall metabolic efficiency.

How the Test Works

1. Order Your Test Kit

Order online or pick up in-clinic. All kits include full instructions and prepaid return shipping.

2. Collect Your Sample

A simple urine sample collected at home. No blood draw required.

3. Send Your Sample

Return your sample using the prepaid tracked envelope provided.

4. Receive Your Results

Your detailed report will be available within 10–14 business days, with optional clinical interpretation.

Who Is This Test For?

The EndoInsight panel is recommended for individuals with:

Hormonal imbalance or cycle concerns
Menopause or perimenopause symptoms
Chronic stress, burnout or fatigue
PMS or PMDD
Fertility challenges
Sleep issues
Low libido
Suspected toxin exposure
Persistent mood imbalance

It is also ideal for anyone looking for a comprehensive overview of endocrine and metabolic health.

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