What is the Adrenal Cortex Antibodies Test?

The Adrenal Cortex Antibodies test measures autoantibodies directed against the adrenal cortex, the outer layer of the adrenal glands responsible for producing essential hormones such as cortisol and aldosterone. When these antibodies are present, they suggest an autoimmune process that progressively damages adrenal tissue.

This test is primarily used to identify autoimmune adrenalitis, the most common cause of primary adrenal insufficiency (Addison’s disease). Autoimmune destruction of the adrenal cortex leads to reduced hormone production, which can cause serious metabolic, cardiovascular and immune-related consequences if left untreated.

Because adrenal insufficiency can develop gradually and present with vague symptoms, antibody testing plays a crucial role in early detection and risk assessment.

Why do I need a test for Adrenal Cortex Antibodies?

You may need this test if you have symptoms suggestive of adrenal insufficiency or if blood tests show low cortisol levels. Autoimmune adrenal disease often progresses silently before becoming clinically apparent, making early identification essential.

This test is also recommended for individuals with other autoimmune conditions, as adrenal cortex antibodies can be part of autoimmune polyglandular syndromes. Detecting antibodies early allows closer monitoring and timely intervention before a potentially life-threatening adrenal crisis occurs.

Symptoms and scenarios where testing is recommended:

• Chronic fatigue or weakness
• Unexplained weight loss
• Low blood pressure or dizziness
• Salt craving
• Hyperpigmentation of skin or gums
• Recurrent nausea, vomiting or abdominal pain
• Low cortisol or abnormal ACTH results
• Existing autoimmune diseases (thyroid, type 1 diabetes)
• Family history of Addison’s disease

Benefits of the Adrenal Cortex Antibodies Test

• Identifies autoimmune Addison’s disease
  Confirms immune-mediated destruction of the adrenal glands.
• Supports early diagnosis before severe symptoms develop
  Allows monitoring before cortisol levels become critically low.
• Helps differentiate primary from secondary adrenal insufficiency
  Antibodies indicate a primary adrenal cause rather than pituitary dysfunction.
• Assists in autoimmune polyglandular syndrome diagnosis
  Important for patients with multiple autoimmune conditions.
• Guides long-term monitoring strategies
  Antibody-positive individuals can be monitored closely for adrenal decline.
• Reduces risk of adrenal crisis
  Early detection supports timely hormone replacement planning.
• Provides clarity in unexplained fatigue cases
  Helps rule in or out adrenal autoimmune involvement.
• Simple, non-invasive diagnostic tool
  Requires only a standard blood sample.

Step-by-Step: How Testing Works

Choose your preferred testing method

You can attend one of our UK partner clinics or arrange a home or hotel visit with a mobile phlebotomist.

Option 1 – In-Clinic Blood Draw

1. Select your nearest UK clinic and book an appointment.
2. A clinician or phlebotomist collects a venous blood sample.
3. The sample is analysed for adrenal cortex antibodies.
4. Results are delivered securely online.

Option 2 – Home or Hotel Phlebotomy (+£60)

1. Book a UK-wide home or hotel visit at a convenient time.
2. A trained phlebotomist collects your blood sample on-site.
3. The sample is safely packaged and sent to the laboratory.
4. Results are uploaded digitally without the need to travel.

Access your report

You can download and share your results with your GP or endocrinologist for further evaluation.

Your Results Explained

Low / Negative Levels

A negative result indicates no detectable adrenal cortex antibodies.
This makes autoimmune Addison’s disease unlikely at the time of testing, although early disease cannot be fully excluded.

Normal / Expected Range

An expected result confirms absence of autoimmune activity against adrenal tissue.
If symptoms persist, functional adrenal hormone tests may still be required.

High / Positive Levels

A positive result indicates autoimmune adrenal involvement.
This strongly supports a diagnosis of autoimmune adrenalitis and increases the risk of developing or progressing Addison’s disease.
Further endocrine assessment and long-term monitoring are usually recommended.