Liver Kidney Microsomal Antibodies
The LKM Antibodies test detects immune antibodies linked to autoimmune liver disease. It is mainly used in the diagnosis of autoimmune hepatitis.
Turnaround time
7 days
Biomarkers count
1
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Details about Liver Kidney Microsomal Antibodies
What is the Liver Kidney Microsomal Antibodies test?
The Liver Kidney Microsomal (LKM) Antibodies test is a blood test that detects autoantibodies directed against enzymes found in liver and kidney cells, particularly cytochrome P450 enzymes.
LKM antibodies are most commonly associated with autoimmune hepatitis type 2 (AIH-2), a condition in which the immune system mistakenly attacks liver tissue, leading to inflammation and potential liver damage.
This test is used as part of a broader autoimmune liver disease work-up and is interpreted alongside liver enzymes, immunoglobulins, and other autoimmune markers.
Why do I need a Liver Kidney Microsomal Antibodies test?
Autoimmune liver disease can progress silently and may mimic other liver conditions. Identifying autoimmune markers allows early diagnosis and appropriate treatment.
You may need an LKM Antibodies test if you:
- Have persistently abnormal liver function tests
- Have suspected autoimmune hepatitis
- Have unexplained liver inflammation
- Are being assessed for chronic liver disease
- Have symptoms not explained by alcohol or viral hepatitis
- Have a personal or family history of autoimmune disease
- Need differentiation between liver disease causes
Symptoms associated with autoimmune liver disease may include:
- Fatigue
- Jaundice (yellowing of skin or eyes)
- Abdominal discomfort
- Nausea
- Joint pain
- Dark urine
- Itching
Benefits of the LKM Antibodies test
- Supports diagnosis of autoimmune hepatitis
Particularly type 2 autoimmune hepatitis. - Differentiates liver disease causes
Helps distinguish autoimmune from viral or metabolic causes. - Clinically established autoimmune marker
Used in hepatology and immunology. - Guides further diagnostic testing
Indicates need for imaging or biopsy. - Supports early intervention
Enables timely immunosuppressive treatment. - Useful in complex liver cases
When standard causes are excluded. - Complements other autoimmune tests
Works alongside ANA, SMA and IgG. - Simple blood test
Requires only one blood sample.
Step by step – how the test works
You can access LKM Antibodies testing UK-wide through two options:
- Clinic appointment
Attend your nearest UK clinic where a healthcare professional will take your blood sample. - At-home or hotel visit (£60 extra)
A qualified phlebotomist comes to your home or hotel, so you don’t need to travel.
Your sample is analysed in an accredited UK laboratory and results are delivered securely.
Your results explained
Negative LKM antibodies
No evidence of LKM-associated autoimmune liver disease.
Typical UK interpretation:
- LKM antibodies: Negative
Low-positive LKM antibodies
May suggest early or mild autoimmune activity; clinical correlation required.
Typical UK interpretation:
- Low-titre positive
High-positive LKM antibodies
Strongly suggest autoimmune hepatitis type 2.
Typical UK interpretation:
- High-titre positive
Results must be interpreted alongside liver enzymes, IgG levels and clinical findings.
How It Works
Simple steps to get your results
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Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
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WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.