Myeloperoxidase Antibodies
Private Myeloperoxidase Antibodies testing in London for £110.99, measuring one MPO autoimmune marker with results expected in around 2 days.
Turnaround time
2 business days
Biomarkers count
1
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Overview of the Myeloperoxidase Antibodies Test
The Myeloperoxidase Antibodies blood test measures autoantibodies directed against Myeloperoxidase, or MPO, an enzyme found mainly within neutrophils.
The test assesses 1 specialist autoimmune biomarker: Myeloperoxidase Antibodies.
MPO antibodies are one of the two principal antigen-specific antibody groups associated with ANCA-associated vasculitis.
The other major target is Proteinase 3, or PR3.
MPO antibodies are frequently associated with a perinuclear ANCA staining pattern, commonly called p-ANCA.
Antigen-specific testing for MPO provides more precise information than the fluorescence pattern alone.
MPO antibodies are particularly associated with microscopic polyangiitis.
They can also occur in eosinophilic granulomatosis with polyangiitis and selected kidney-limited vasculitic disorders.
These diseases can cause inflammation and damage within small blood vessels.
The kidneys, lungs, skin, nerves and other organs can be affected.
Kidney involvement can cause blood and protein to appear in urine and may lead to a rapid decline in renal function.
Lung involvement can range from inflammatory infiltrates to potentially serious pulmonary haemorrhage.
A positive MPO result does not by itself diagnose vasculitis.
The result must be interpreted with symptoms, urine findings, kidney function, inflammatory markers, imaging and sometimes tissue biopsy.
Some people with genuine ANCA-associated vasculitis are antibody-negative.
MPO antibodies can also occasionally occur outside active systemic vasculitis.
What Does the Myeloperoxidase Antibodies Test Check?
The test measures autoantibodies directed against Myeloperoxidase. This test measures 1 specialist biomarker.
Myeloperoxidase Antibodies
Measures MPO-specific autoantibodies associated particularly with microscopic polyangiitis and other ANCA-associated vasculitic syndromes.
Who May Benefit From the Myeloperoxidase Antibodies Test?
MPO testing can be useful when symptoms or other investigations raise concern about small-vessel vasculitis.
People with unexplained blood or protein in urine - Vasculitic kidney inflammation can affect the glomeruli.
People with rapidly declining kidney function - MPO-associated glomerulonephritis can progress quickly.
People with unexplained lung inflammation - Small-vessel vasculitis can involve pulmonary tissue.
People with coughing blood and suspected vasculitis - Pulmonary haemorrhage is a serious potential complication.
People with a positive ANCA result - MPO testing can establish the antigen specificity.
People with neuropathy and systemic inflammatory symptoms - Small-vessel vasculitis can affect peripheral nerves.
People with a previous positive MPO result - Repeat measurement can contribute to specialist follow-up.
People referred by nephrology or rheumatology - MPO is a key targeted autoimmune marker.
How to Prepare
Do not stop immunosuppressive treatment solely to increase antibody detection.
MPO should be interpreted with organ-function tests and the complete clinical picture.
Symptoms and Reasons to Consider the Myeloperoxidase Antibodies Test
MPO-associated vasculitis can affect several organ systems.
Blood in the urine - Glomerular inflammation can cause haematuria.
Protein in the urine - Kidney damage can allow protein leakage.
Rapid deterioration in kidney function - ANCA-associated glomerulonephritis can progress quickly.
Persistent cough or unexplained breathlessness - Pulmonary vasculitis can affect respiratory function.
Coughing blood - This can occur with pulmonary capillary inflammation and haemorrhage.
New numbness or weakness affecting individual nerves - Vasculitic neuropathy can occur.
Skin purpura or unexplained inflammatory rash - Small-vessel inflammation can affect the skin.
Persistent fever, fatigue or weight loss with organ abnormalities - Systemic vasculitis can produce constitutional symptoms.
Coughing blood, severe breathlessness or rapidly declining kidney function requires urgent medical assessment.
ANCA-associated vasculitis can cause permanent organ damage if significant disease is not treated promptly.
How to Book Your Myeloperoxidase Antibodies Test
The MPO Antibodies test can be booked privately for targeted ANCA-associated vasculitis assessment.
Choose the Myeloperoxidase Antibodies
Select the individual MPO antibody blood test online.
Select your sample collection option
Choose an in-clinic blood draw or professional home or hotel phlebotomy where suitable.
Attend your appointment
A trained healthcare professional collects the required venous blood sample.
Laboratory analysis
Your serum undergoes specialist measurement of Myeloperoxidase Antibodies.
Receive your results securely
Your authorised result is delivered securely and can be interpreted alongside ANCA, PR3, kidney function and urine results.
When Will I Receive My Results?
The current specialist laboratory turnaround for Myeloperoxidase Antibodies is approximately 2 days after laboratory receipt.
The sample undergoes specialist immunology analysis, laboratory quality control and result authorisation.
Additional vasculitis testing can take longer where clinically required.
Understanding Your Results
A negative result means significant MPO antibodies were not detected.
This makes MPO-associated ANCA vasculitis less likely but does not exclude every form of vasculitis.
A positive result indicates detectable Myeloperoxidase autoantibodies.
Strong positivity in somebody with compatible kidney, lung or systemic findings can provide important support for ANCA-associated vasculitis.
The antibody concentration does not independently determine disease severity.
MPO antibodies can also persist after treatment.
Clinical activity should therefore be assessed using symptoms, kidney function, urine results, inflammatory markers and other investigations.
ANCA staining and PR3 antibodies can provide complementary information.
Why Book With London Blood Tests?
London Blood Tests provides private MPO antibody testing for specialist vasculitis assessment.
Measures MPO-specific antibodies - The test directly identifies one of the major ANCA antigen targets.
Relevant to microscopic polyangiitis - MPO is commonly associated with this form of small-vessel vasculitis.
Useful after a positive ANCA result - Antigen-specific testing clarifies the antibody target.
Relevant to kidney vasculitis - MPO-associated glomerulonephritis can significantly affect renal function.
Relevant to pulmonary disease - ANCA-associated vasculitis can involve the lungs.
Can complement Proteinase 3 testing - PR3 represents the other major ANCA antigen specificity.
Rapid specialist turnaround - Results are expected approximately 2 days after laboratory receipt.
Clear pricing - The Myeloperoxidase Antibodies test costs £110.99.
Private Myeloperoxidase Antibodies Blood Test in London
London Blood Tests provides private Myeloperoxidase Antibody testing for people requiring assessment of ANCA-associated vasculitis.
The test costs £110.99 and measures 1 specialist autoimmune biomarker.
Results are expected approximately 2 days after laboratory receipt.
A positive result supports vasculitis assessment but does not establish the diagnosis independently.