Myeloperoxidase Antibodies
The Myeloperoxidase Antibodies test detects autoantibodies linked to autoimmune inflammation of blood vessels. It is commonly used in the investigation of ANCA-associated vasculitis.
Turnaround time
1-2 days
Biomarkers count
1
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Details about Myeloperoxidase Antibodies
What is the Myeloperoxidase Antibodies test?
The Myeloperoxidase (MPO) Antibodies test measures antibodies directed against myeloperoxidase, an enzyme found inside neutrophils (a type of white blood cell). These antibodies are part of the ANCA (anti-neutrophil cytoplasmic antibody) group and are typically referred to as p-ANCA (MPO-ANCA).
MPO antibodies are strongly associated with certain autoimmune conditions that cause inflammation of small blood vessels. The test is an important tool in diagnosing and monitoring ANCA-associated vasculitis, particularly when symptoms involve the kidneys, lungs, skin, or nervous system.
Why do I need a Myeloperoxidase Antibodies test?
Autoimmune vasculitis can present with vague or multisystem symptoms and may cause serious organ damage if not identified early.
You may need this test if you experience:
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Persistent unexplained fatigue
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Kidney abnormalities (blood or protein in urine)
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Shortness of breath or coughing up blood
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Skin rashes or purpura
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Joint or muscle pain
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Nerve symptoms such as numbness or weakness
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Unexplained inflammation markers
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Suspected autoimmune disease affecting multiple organs
The test helps determine whether symptoms are driven by immune-mediated blood vessel inflammation.
Benefits of the test
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Key marker of autoimmune vasculitis
Strongly linked to MPO-ANCA conditions. -
Supports early diagnosis
Helps identify disease before irreversible damage. -
Guides further specialist investigation
Supports referral and imaging decisions. -
Clarifies cause of systemic inflammation
Distinguishes autoimmune from infectious causes. -
Simple blood-based testing
Requires only one blood sample. -
Widely used in rheumatology and nephrology
Standard ANCA marker. -
Supports disease monitoring
May be used alongside clinical assessment. -
Improves diagnostic confidence
Reduces uncertainty in complex presentations.
Step-by-step: How we offer testing
Clinic-based testing (UK-wide)
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Choose your nearest UK clinic
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Attend your appointment
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Blood sample taken by a clinician
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Sample sent to the laboratory
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Results issued once analysis is complete
Home or hotel visit (+£60, UK-wide)
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Mobile phlebotomist attends your location
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Blood sample taken at home or hotel
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Sample securely transported to the laboratory
Your results explained
Negative MPO antibodies
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No MPO antibodies detected
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UK standard: Negative
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Makes MPO-associated vasculitis less likely
Low to moderate positive
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MPO antibodies detected at low or moderate level
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UK standard: Positive (low/moderate)
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May indicate early or limited autoimmune activity
High positive
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Significantly elevated MPO antibodies
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UK standard: High positive
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Strongly suggests active ANCA-associated vasculitis
Results should always be interpreted alongside symptoms, other ANCA tests, and clinical findings.
How It Works
Simple steps to get your results
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Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
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WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.