Tissue Transglutaminase IgG
Private Tissue Transglutaminase IgG testing in London for £102, measuring one coeliac-related antibody marker with results in around 5 days.
Turnaround time
5 business days
Biomarkers count
1
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Overview of the Tissue Transglutaminase IgG Test
The Tissue Transglutaminase IgG blood test measures IgG antibodies directed against tissue transglutaminase, an enzyme that is an important autoimmune target in coeliac disease.
The test assesses 1 specialist autoimmune marker: Tissue Transglutaminase IgG.
Coeliac disease is an autoimmune condition triggered by exposure to gluten in genetically susceptible people.
Gluten is present in wheat, barley and rye.
When a person with coeliac disease consumes gluten, the immune system reacts abnormally and can damage the lining of the small intestine.
Tissue transglutaminase, often abbreviated to tTG, is one of the principal autoantigens involved.
For most people undergoing initial coeliac screening, Tissue Transglutaminase IgA together with Total IgA is the preferred first-line serological approach.
Tissue Transglutaminase IgG has a more specific role.
It can be particularly useful in people with IgA deficiency, because an IgA-based coeliac test may be falsely negative when insufficient IgA is produced.
The test can also form part of an extended coeliac serology assessment where previous results are difficult to interpret.
A positive tTG-IgG result does not automatically establish coeliac disease.
The strength of the antibody response, Total IgA status, symptoms and other serological or histological findings are important.
The test is also affected by gluten intake.
Coeliac antibodies can fall after gluten is removed from the diet.
Someone who has already adopted a strict gluten-free diet may therefore have negative serology despite having coeliac disease.
Testing should ideally occur while the person is still consuming gluten unless a clinician has specifically advised otherwise.
What Does the Tissue Transglutaminase IgG Test Check?
The test measures IgG antibodies against tissue transglutaminase and is particularly useful during coeliac investigation where IgA deficiency is present or suspected. This test measures 1 specialist biomarker.
Tissue Transglutaminase IgG
Measures IgG autoantibodies directed against tissue transglutaminase, supporting investigation of coeliac disease particularly where IgA deficiency limits the usefulness of tTG-IgA testing.
Who May Benefit From the Tissue Transglutaminase IgG Test?
tTG-IgG is particularly useful in selected coeliac investigations rather than as a replacement for tTG-IgA in everyone.
People with IgA deficiency undergoing coeliac assessment - IgG-based serology can provide useful information when IgA antibodies may be unreliable.
People with coeliac-type symptoms and low Total IgA - tTG-IgG can contribute to an appropriate alternative testing pathway.
People with unexplained iron deficiency or nutritional abnormalities - Coeliac disease can impair absorption of iron and other nutrients.
People with chronic diarrhoea or malabsorption symptoms - Persistent gastrointestinal symptoms can prompt coeliac serology.
People with a family history of coeliac disease - First-degree relatives have a higher likelihood of the condition.
People with autoimmune thyroid disease or type 1 diabetes - Coeliac disease occurs more frequently in selected autoimmune populations.
People with previous inconclusive coeliac serology - Additional IgG testing may help where earlier results were difficult to interpret.
People specifically advised to undergo IgG-based coeliac testing - The result is most useful when Total IgA status and gluten exposure are known.
How to Prepare
Do not begin a gluten-free diet solely because coeliac disease is suspected before appropriate testing has been completed.
Removing gluten can cause antibody levels to fall and may make subsequent diagnosis more difficult.
Symptoms and Reasons to Consider the Tissue Transglutaminase IgG Test
Coeliac disease can produce gastrointestinal, nutritional and systemic symptoms, but some people have few or no obvious digestive complaints.
Persistent diarrhoea - Small-intestinal inflammation can impair normal absorption and bowel function.
Abdominal bloating or discomfort - Gastrointestinal symptoms are common but non-specific.
Unexplained iron deficiency - Reduced intestinal iron absorption can occur in coeliac disease.
Unexplained Folate or Vitamin B12 abnormalities - Malabsorption can affect several nutrients.
Unintentional weight loss - More significant malabsorption can affect body weight.
Persistent fatigue - Nutritional deficiency or anaemia can contribute to tiredness.
A family history of coeliac disease - Genetic susceptibility clusters within families.
Known IgA deficiency with possible coeliac symptoms - IgG-based serology becomes particularly relevant.
Tissue Transglutaminase IgG should not be used to diagnose non-coeliac gluten sensitivity.
A negative result does not reliably exclude coeliac disease if the person has already stopped eating gluten.
Persistent symptoms or strongly suspected coeliac disease can require further serology, HLA testing or gastroenterology assessment.
How to Book Your Tissue Transglutaminase IgG Test
The Tissue Transglutaminase IgG test can be booked privately for specialist IgG-based coeliac serology.
Choose the Tissue Transglutaminase IgG
Select the individual tTG-IgG blood test online.
Select your sample collection option
Choose an in-clinic blood draw or professional home or hotel phlebotomy where suitable.
Attend your appointment
A trained healthcare professional collects the required venous blood sample and gluten intake or known IgA deficiency can be documented.
Laboratory analysis
Your serum undergoes specialist measurement of Tissue Transglutaminase IgG.
Receive your results securely
Your authorised result is delivered securely and can be interpreted alongside Tissue Transglutaminase IgA and Total IgA where appropriate.
When Will I Receive My Results?
The current London Blood Tests catalogue lists Tissue Transglutaminase IgG at £102.
The specialist laboratory turnaround is approximately 5 days after laboratory receipt.
The sample undergoes immunological antibody analysis, quality-control procedures and result authorisation.
Turnaround begins when the specimen reaches the laboratory rather than necessarily from the exact time the blood sample is collected.
Understanding Your Results
A negative tTG-IgG result means significant IgG antibodies against tissue transglutaminase were not detected according to the laboratory assay.
The significance depends on why IgG testing was selected.
In a person with normal IgA production, tTG-IgA is generally the preferred first-line antibody test.
In somebody with IgA deficiency, tTG-IgG can provide more useful information.
A positive result can support coeliac autoimmunity, particularly where symptoms, gluten exposure and IgA status are consistent.
It does not independently prove coeliac disease.
Additional testing can include Total IgA, tTG-IgA, Endomysial Antibodies, deamidated Gliadin antibodies or, in selected circumstances, HLA-DQ2/DQ8 genetics.
Gastroenterology assessment and small-bowel biopsy may also be required depending on the clinical situation.
A person already following a gluten-free diet can develop falling or negative antibody results despite underlying coeliac disease.
Why Book With London Blood Tests?
London Blood Tests provides private access to Tissue Transglutaminase IgG testing for specialist coeliac assessment.
Measures a recognised coeliac autoantibody - The test assesses IgG antibodies directed against tissue transglutaminase.
Particularly useful in IgA deficiency - IgG-based testing can provide information when tTG-IgA is unreliable.
Can complement Total IgA - Knowing overall IgA status helps determine which coeliac antibodies are most informative.
Can complement tTG-IgA testing - The two assays have different roles depending on immune status.
Relevant to unexplained nutritional deficiency - Coeliac disease can impair absorption of iron, folate and other nutrients.
Specialist laboratory analysis - Samples undergo dedicated immunology testing.
Professional blood collection - Clinic and suitable home or hotel phlebotomy appointments are available.
Clear pricing - The Tissue Transglutaminase IgG test costs £102.
Private Tissue Transglutaminase IgG Blood Test in London
London Blood Tests provides private Tissue Transglutaminase IgG testing for people requiring specialist coeliac serology.
The test costs £102 and assesses 1 specialist biomarker.
Results are expected approximately 5 days after laboratory receipt.
tTG-IgG is particularly useful when IgA deficiency is present and should be interpreted alongside gluten intake, Total IgA and other coeliac investigations.