1,25-dihydroxyvitamin D (calcitriol)
This test measures 1,25-dihydroxyvitamin D, the biologically active form of vitamin D. It is used to investigate calcium imbalance, kidney disease and...
Advanced HRT Optimisation Profile
249.00
This advanced panel evaluates hormone balance, metabolic health and cardiovascular risk during or after HRT. It provides deeper insight for personalised optimisation and safe dose adjustment.
Turnaround time
2-3 days
Biomarkers count
31
Same-Day Appointments
UKAS Accredited Labs
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Under 18? Patients under 18 can only be seen at GB Medlabs and Clinilabs, Monday to Friday only.
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Details about Advanced HRT Optimisation Profile
What is the Advanced HRT Optimisation Profile?
The Advanced HRT Optimisation Profile is a comprehensive follow-up blood panel designed for individuals already on hormone replacement therapy (HRT) or considering optimisation beyond baseline treatment. It goes deeper than standard testing by assessing hormone balance alongside thyroid performance, insulin resistance, cardiovascular risk, inflammation, and nutritional status — all of which influence how well hormone therapy works.
This profile helps clinicians refine dosing, identify barriers to symptom improvement, and ensure long-term safety while maximising therapeutic benefit.
What does the profile include?
Hormone Optimisation
Oestradiol
Progesterone
Testosterone (Free and Total)
Sex Hormone Binding Globulin (SHBG)
DHEA-S
Cortisol (AM)
These markers evaluate hormone balance, adrenal function, androgen status, and therapy response.
Thyroid Deep Dive
Thyroid Stimulating Hormone (TSH)
Free Thyroxine (Free T4)
Free Tri-iodothyronine (Free T3)
Thyroid health significantly affects metabolism, energy levels, and hormone effectiveness.
Metabolic & Insulin Resistance
Fasting Glucose
HbA1c
Fasting Insulin
HOMA-IR (calculated)
Insulin resistance can blunt hormone response and contribute to weight gain or fatigue.
Cardiovascular Risk — Advanced
Lipid Profile (Total Cholesterol, HDL, LDL, Triglycerides)
Apolipoprotein A1
Apolipoprotein B
Lipoprotein(a)
These markers provide a deeper understanding of cardiovascular risk beyond standard cholesterol testing.
Inflammation & Ageing
High-Sensitivity C-Reactive Protein (hs-CRP)
Homocysteine
These markers reflect systemic inflammation, vascular health, and biological ageing processes.
Nutritional & Energy Status
Vitamin D
Vitamin B12
Folate
Ferritin
Magnesium
Zinc
Nutrient status plays a critical role in hormone metabolism, mitochondrial function, and energy levels.
Why do I need an Advanced HRT Optimisation Profile?
Hormone therapy outcomes depend on multiple systems, not just reproductive hormones. Without advanced monitoring, issues like insulin resistance, inflammation, or thyroid dysfunction may limit results.
This panel is recommended if you:
• Are already on HRT and want optimisation
• Have persistent symptoms despite treatment
• Experience fatigue, weight gain or mood changes
• Want precise hormone balancing
• Are monitoring long-term safety
• Are pursuing longevity or preventative health strategies
Benefits of the test
1. Optimises hormone therapy safely
2. Detects insulin resistance affecting results
3. Assesses cardiovascular risk comprehensively
4. Evaluates adrenal and thyroid influence
5. Identifies inflammation impacting symptoms
6. Supports personalised dosing decisions
7. Improves long-term health outcomes
8. Provides advanced monitoring beyond standard care
Expanded benefit explanation
By evaluating hormones alongside metabolic and cardiovascular factors, this panel allows true optimisation rather than symptom-based adjustments alone.
Step-by-step — How testing works
We offer two UK-wide options:
Clinic testing
• Choose your nearest UK clinic
• Blood sample collected by clinician
• Samples analysed by accredited laboratory
• Results delivered securely
Home visit (+£60)
• Phlebotomist visits your home or hotel
• Blood collected safely and professionally
• Samples sent to laboratory
• Results delivered securely
Both services are available UK-wide.
Your results explained
Sub-optimal levels
May indicate hormonal imbalance, metabolic resistance, inflammation or nutrient deficiencies requiring optimisation.
Optimal ranges
Suggest therapy is balanced and effective.
Elevated markers
May indicate cardiovascular risk, insulin resistance or inflammatory burden requiring intervention.
UK laboratory reference ranges are provided with all results.
How It Works
Simple steps to get your results
1
Book Online
Choose your test online and book in seconds. Select your preferred clinic location or home visit option.
2
Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
3
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
Take control of your health with London Blood Tests
WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.
Frequently Asked Questions
Yes, primarily for optimisation and monitoring.
Yes, fasting is recommended for metabolic markers.
They detect insulin resistance affecting hormone response.
Yes, adrenal health influences hormone balance.
They provide more accurate cardiovascular risk insight.
Yes, chronic inflammation can blunt benefits.
Yes, thyroid dysfunction can mimic hormone imbalance.
Absolutely, especially vitamin D, iron and B vitamins.
Typically every 3–6 months during optimisation.
Yes, for any hormone optimisation protocol.
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