What is the Advanced TRT Profile?

The Advanced TRT Profile is a comprehensive blood test panel designed for men considering testosterone replacement therapy (TRT) or already undergoing treatment. It goes beyond basic testosterone testing to assess hormonal balance, prostate safety, cardiovascular risk, inflammation, metabolic health, and organ function.

This profile includes:

Androgens & Hormonal Regulation

• Testosterone

• Free Testosterone (calculated)

• Free Androgen Index (FAI)

• Sex Hormone Binding Globulin (SHBG)

• Albumin

• Follicle Stimulating Hormone (FSH)

• Luteinising Hormone (LH)

• Prolactin

• Oestradiol

Prostate Health

• Total Prostate Specific Antigen (PSA)

Thyroid Health

• Thyroid Stimulating Hormone (TSH)

• Free T3 (triiodothyronine)

• Free T4 (thyroxine)

Inflammation & Stress

• High Sensitivity C-Reactive Protein (hsCRP)

• Cortisol

Blood Health

• Full Blood Count (with 5-part white cell differential)

Metabolic & Glucose Control

• Glucose

• HbA1c (Glycosylated Haemoglobin)

Lipid & Cardiovascular Risk

• Total Cholesterol

• HDL Cholesterol

• LDL Cholesterol

• Non-HDL Cholesterol

• Total Cholesterol : HDL Ratio

• Apolipoprotein B

Liver & Kidney Function

• Alanine Aminotransferase (ALT)

• Aspartate Aminotransferase (AST)

• Alkaline Phosphatase (ALP)

• Gamma GT

• Total Bilirubin

• Urea

• Creatinine

• Estimated Glomerular Filtration Rate (eGFR)

Nutrients

• Ferritin

• Vitamin D (25-OH)

Together, these markers provide a high-level clinical overview required for safe TRT initiation and optimisation.

Why do I need an Advanced TRT Profile?

TRT can significantly improve quality of life when appropriately prescribed, but it must be medically justified and safely monitored. Inadequate screening increases the risk of cardiovascular issues, prostate complications, hormone imbalance, and poor treatment outcomes.

This advanced profile ensures testosterone therapy is based on complete physiological insight, not just total testosterone levels.

You may benefit from this test if you:

• Are considering starting TRT

• Are already on TRT and want safety monitoring

• Have symptoms of low testosterone

• Want to assess prostate and cardiovascular risk

• Experience fatigue, low libido, or mood changes

• Want to optimise TRT dosing safely

• Have concerns about inflammation or metabolism

• Want clinician-level hormone assessment

Benefits of the Advanced TRT Profile

1. Comprehensive TRT readiness assessment
   Ensures safe and appropriate therapy initiation.

2. Evaluates true androgen status
   Measures total, free, and bioavailable testosterone.

3. Assesses prostate safety
   PSA monitoring supports long-term risk management.

4. Monitors cardiovascular risk
   Lipids and ApoB assess atherogenic risk.

5. Screens for TRT-related complications
   Blood count and inflammation markers detect adverse effects.

6. Evaluates thyroid and metabolic health
   Supports energy, weight, and hormone balance.

7. Supports dose optimisation and monitoring
   Reduces overtreatment and side effects.

8. Clinically robust hormone profile
   Suitable for long-term TRT management.

Step-by-step – how we offer Advanced TRT Profile testing

Clinic-based testing (UK-wide)

• Choose your nearest UK clinic

• Attend your appointment

• Blood samples collected by a qualified clinician or phlebotomist

• Samples are sent to the laboratory for analysis

At-home or hotel testing (+£60)

• A qualified phlebotomist visits your home or hotel

• Blood samples collected in a comfortable setting

• No clinic visit or travel required

Both services are available UK-wide.

Your Advanced TRT Profile results explained

Findings suggesting low testosterone or imbalance

Low testosterone, abnormal free androgen index, raised SHBG, or disrupted LH/FSH patterns may indicate primary or secondary hypogonadism. Elevated oestradiol or prolactin can worsen symptoms and affect TRT response.

UK reference interpretation:

• Abnormal hormones: Outside laboratory reference ranges

Results within safe and optimal ranges

Results within range suggest balanced hormone regulation, stable prostate markers, acceptable cardiovascular risk, and adequate organ function. This supports safe TRT initiation or continuation.

UK reference interpretation:

• Normal: Within laboratory reference ranges

Results indicating increased risk or monitoring needs

Elevated PSA, haematological changes, raised hsCRP, lipid abnormalities, or liver enzyme elevations may require dose adjustment, further evaluation, or delayed therapy.

UK reference interpretation:

• High-risk markers: Above laboratory reference ranges