Angiotensin Converting Enzyme
Private Angiotensin Converting Enzyme blood test in London for £119.99, measuring ACE with results in approximately 2 business days.
Turnaround time
2 business days
Biomarkers count
1
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Overview of the Angiotensin Converting Enzyme
The Angiotensin Converting Enzyme blood test measures the concentration of angiotensin-converting enzyme, commonly abbreviated to ACE, in the bloodstream.
ACE forms part of the renin-angiotensin system, which helps regulate blood pressure and fluid balance. The enzyme converts angiotensin I into angiotensin II, a biologically active substance involved in narrowing blood vessels and influencing blood-pressure regulation.
In clinical testing, serum ACE is used particularly as a supporting marker when sarcoidosis is being investigated or monitored. Sarcoidosis is an inflammatory condition characterised by collections of immune cells known as granulomas, which can affect the lungs, lymph nodes, skin, eyes and other organs. Cells associated with granulomas may produce increased quantities of ACE.
The test contains 1 biomarker: Angiotensin Converting Enzyme.
ACE is not specific to sarcoidosis. Raised concentrations can occur in other conditions, and some people with confirmed sarcoidosis have ACE levels within the laboratory reference range. For this reason, an ACE result cannot independently diagnose or exclude sarcoidosis.
Where sarcoidosis is suspected, the result may be considered alongside symptoms, chest imaging, lung function testing, calcium, liver tests and, where clinically required, tissue biopsy or other specialist investigations.
What Does the Angiotensin Converting Enzyme Test Check?
This test measures 1 biomarker.
Angiotensin Converting Enzyme
Measures the concentration of ACE circulating in the blood. ACE may be increased in some people with active sarcoidosis because cells associated with granulomas can produce the enzyme. The result can provide supporting information during investigation or monitoring, but it is neither sufficiently sensitive nor sufficiently specific to diagnose sarcoidosis by itself
Who May Benefit From the Angiotensin Converting Enzyme Test?
This test may be suitable for people whose symptoms, imaging or previous laboratory findings have led a clinician to consider sarcoidosis or another granulomatous condition.
Possible sarcoidosis - ACE can provide additional laboratory information when sarcoidosis forms part of the clinical differential diagnosis.
Previously diagnosed sarcoidosis - Where ACE was elevated at diagnosis, repeat testing may sometimes help follow changes over time alongside clinical assessment.
Persistent unexplained cough - Chronic respiratory symptoms may prompt investigation for sarcoidosis and numerous other lung conditions.
Unexplained changes on chest imaging - ACE may form part of a wider assessment where an X-ray or CT scan shows findings potentially compatible with granulomatous disease.
Unexplained breathlessness - Respiratory symptoms combined with other clinical findings may lead to further investigation for inflammatory lung disease.
Eye, skin or joint symptoms with possible systemic inflammation - Sarcoidosis can affect organs outside the lungs, making the wider clinical pattern important.
Previously raised ACE - Repeat measurement can help establish whether an elevated result has persisted or changed.
Monitoring response to treatment - In selected patients whose ACE was raised initially, trends may provide supplementary information during treatment monitoring.
Specialist-requested ACE testing - The test can be arranged privately where a GP, respiratory physician, rheumatologist or other specialist has specifically requested serum ACE.
How to Prepare
Do not stop ACE-inhibitor medication, corticosteroids or any other prescribed treatment simply to obtain a different ACE result. Medication changes should only be made under the direction of the clinician responsible for your care.
Symptoms and Reasons to Consider the Angiotensin Converting Enzyme Test
You may wish to consider the Angiotensin Converting Enzyme test where sarcoidosis or another granulomatous inflammatory condition is being investigated.
Persistent dry cough - Lung involvement is common in sarcoidosis, although chronic cough has many other possible causes.
Unexplained shortness of breath - Breathlessness can occur with pulmonary sarcoidosis but requires appropriate respiratory assessment.
Persistent fatigue - Fatigue is frequently reported in systemic inflammatory conditions but is highly non-specific.
Chest discomfort - Respiratory or chest symptoms may sometimes accompany pulmonary disease but should not be attributed to sarcoidosis without clinical investigation.
Red, painful or irritated eyes - Sarcoidosis can affect the eyes, and persistent ocular symptoms require appropriate ophthalmological assessment.
Unexplained skin lumps or lesions - Certain skin manifestations may occur with sarcoidosis and may sometimes provide an accessible site for further clinical evaluation.
Joint pain or swelling - Musculoskeletal symptoms can occur as part of systemic sarcoidosis but also have many other inflammatory and mechanical causes.
Swollen lymph nodes - Enlarged lymph nodes may be identified clinically or on imaging and can occur in sarcoidosis as well as many other conditions.
Abnormal chest X-ray or CT findings - Bilateral hilar lymphadenopathy or other compatible findings may lead to ACE testing as part of a broader investigation.
Known sarcoidosis requiring follow-up - Repeat ACE measurements may sometimes be useful when the marker was elevated previously and is being followed alongside symptoms and other tests.
ACE should not be used as a stand-alone screening test for sarcoidosis. A substantial proportion of people with the condition can have ACE levels within the reference range, while elevated ACE can occur in other disorders.
Sarcoidosis can involve the lungs, heart, nervous system, eyes and other organs. Symptoms such as significant breathlessness, fainting, palpitations, new neurological symptoms or sudden visual changes require appropriate medical assessment rather than reliance on routine ACE testing.
How to Book Your Angiotensin Converting Enzyme Test
Booking your Angiotensin Converting Enzyme test with London Blood Tests is simple and designed to fit around your schedule.
Choose the Angiotensin Converting Enzyme
Select the Angiotensin Converting Enzyme test online and review the included ACE biomarker before booking.
Select your sample collection option
Choose an in-clinic blood draw (+£35) or a home or hotel phlebotomy visit (+£60) where a qualified phlebotomist collects your sample.
Attend your appointment
A trained professional will collect your blood sample safely and efficiently at the clinic or during your arranged home or hotel visit.
Laboratory analysis
Your sample is sent to the laboratory, where Angiotensin Converting Enzyme is measured.
Receive your results securely
Your results are sent securely by email, ready to review yourself or discuss with a GP, respiratory physician or other suitably qualified healthcare professional.
When Will I Receive My Results?
The expected turnaround time for the Angiotensin Converting Enzyme test is approximately 2 business days.
Your report is sent securely by email once laboratory analysis and authorisation are complete. Turnaround generally begins when the laboratory receives your sample rather than necessarily from the time your blood is collected.
Occasional repeat analysis, laboratory quality checks or sample-related issues may extend the expected turnaround.
Understanding Your Results
Your laboratory report will show your Angiotensin Converting Enzyme (ACE) concentration together with the reference range used by the analysing laboratory.
A raised ACE result may provide supporting evidence of active sarcoidosis when compatible symptoms, imaging or other clinical findings are present. However, an elevated ACE level does not establish the diagnosis because ACE can also increase in other inflammatory, infectious, metabolic and granulomatous conditions.
A normal ACE result does not rule out sarcoidosis. Some people with confirmed or active sarcoidosis do not produce elevated concentrations of circulating ACE.
When ACE was elevated at the time sarcoidosis was diagnosed, falling concentrations may sometimes accompany improvement or treatment response, while rising results may warrant further clinical review. ACE should nevertheless not be used as the only measure of disease activity.
Medication is another important consideration. ACE inhibitors can reduce measured ACE activity, while corticosteroid treatment may also lower ACE concentrations. The clinician interpreting the result should therefore know which medicines you are taking.
Reference ranges vary according to age and laboratory methodology, and children and younger people may naturally have higher ACE concentrations than adults. Your result should always be interpreted against the reference range supplied with your own laboratory report.
Why Book With London Blood Tests?
Private ACE blood testing in London - Access targeted Angiotensin Converting Enzyme testing through London Blood Tests.
Focused one-biomarker test - Measure ACE without having to book a broad general health profile when this is the specific investigation required.
Relevant to sarcoidosis investigation - ACE may provide useful supporting information when sarcoidosis is being considered alongside clinical and imaging findings.
Suitable for selected monitoring - Repeat ACE testing may help follow trends where the marker was elevated previously.
Fast laboratory turnaround - The expected laboratory turnaround is approximately 2 business days.
Clinic and home visit options - Choose an in-clinic blood draw or arrange home or hotel phlebotomy depending on location and availability.
Secure results by email - Receive your authorised laboratory result securely once analysis is complete.
Clear pricing before booking - The Angiotensin Converting Enzyme test is priced at £119.99, with sample collection charges shown separately.
Private Angiotensin Converting Enzyme Blood Test in London
London Blood Tests provides the Angiotensin Converting Enzyme blood test in London for people requiring targeted ACE measurement as part of the investigation or monitoring of sarcoidosis.
The test costs £119.99 and measures one biomarker: Angiotensin Converting Enzyme. It may provide useful additional information where symptoms, imaging or previous clinical findings suggest a granulomatous inflammatory condition.
Clinic appointments are available alongside home and hotel phlebotomy depending on location and availability, providing flexible options for people looking for a private ACE blood test in London or specialist sarcoidosis-related testing near them.
ACE testing cannot independently diagnose sarcoidosis. Where the condition is suspected, a GP or specialist may consider additional investigations such as chest imaging, lung function assessment, Calcium, liver testing and, in selected cases, biopsy.