Apolipoprotein E
Private Apolipoprotein E testing in London for £99, measuring one fasting lipid-transport marker with results expected in around 1–2 days.
Turnaround time
1-2 business days
Biomarkers count
1
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Overview of the Apolipoprotein E Test
The Apolipoprotein E blood test measures Apolipoprotein E protein in the blood, providing information about a protein involved in lipid transport and the clearance of cholesterol-rich remnant particles.
The test assesses 1 specialist lipid marker: Apolipoprotein E (12 hours fasting).
Apolipoprotein E, commonly abbreviated to ApoE, is produced in several tissues, including the liver.
It is carried on several classes of lipoprotein particles.
ApoE plays an important role in helping receptors recognise and clear triglyceride-rich remnant particles from the circulation.
This gives ApoE an important role in the transport and metabolism of cholesterol and triglycerides.
Abnormal ApoE concentration can occur in association with altered lipid metabolism, liver disease and selected inherited lipid disorders.
However, the Apolipoprotein E blood concentration test is not the same as ApoE genetic testing.
Apolipoprotein E Genotype analyses inherited APOE variants such as E2, E3 and E4.
The fasting ApoE blood test measures the circulating protein rather than determining which APOE alleles a person has inherited.
This distinction is particularly important because APOE genotype is sometimes discussed in relation to Alzheimer's disease risk.
A routine circulating ApoE protein measurement should not be presented as a genetic Alzheimer's risk test.
The current test name specifies 12 hours fasting, helping standardise the metabolic conditions under which the sample is collected.
ApoE can be interpreted alongside Total Cholesterol, LDL Cholesterol, HDL Cholesterol, Triglycerides, Apolipoprotein B and other advanced lipid markers where a broader assessment is required.
What Does the Apolipoprotein E Test Check?
The test measures circulating Apolipoprotein E following the specified fasting period and provides information about a protein involved in lipoprotein transport and remnant clearance. This test measures 1 specialist biomarker.
Apolipoprotein E
Measures circulating Apolipoprotein E after a 12-hour fast, supporting specialist assessment of lipid transport and triglyceride-rich remnant-particle metabolism.
Who May Benefit From the Apolipoprotein E Test?
Apolipoprotein E measurement is most useful as part of a specialist lipid or metabolic assessment rather than as a routine standalone cholesterol screen.
People undergoing advanced lipid assessment - ApoE can add information beyond a conventional cholesterol profile.
People with unexplained abnormalities in cholesterol or triglycerides - Specialist apolipoprotein measurement can contribute to further investigation.
People with suspected remnant-lipoprotein abnormalities - ApoE plays an important role in remnant-particle clearance.
People with a family history of unusual lipid disorders - More detailed lipid testing may be appropriate where standard markers do not fully explain the pattern.
People with a previous abnormal ApoE protein result - Repeat measurement can help establish whether the finding persists.
People undergoing specialist cardiovascular risk assessment - ApoE may be interpreted alongside ApoB, ApoA1 and Lipoprotein (a).
People monitoring changes following lipid-related treatment or lifestyle intervention - Repeat specialist testing may occasionally be useful.
People who need a protein measurement rather than genetic ApoE testing - This test measures circulating ApoE and is distinct from Apolipoprotein E Genotype.
How to Prepare
The 12-hour fasting requirement is part of this test's specified collection conditions.
Do not stop prescribed lipid-lowering medication solely to alter the result unless the clinician managing your treatment has specifically instructed you to do so.
Symptoms and Reasons to Consider the Apolipoprotein E Test
Abnormal ApoE protein concentration does not cause a distinctive symptom pattern. Testing is generally prompted by lipid results, family history or specialist metabolic assessment.
Unexpectedly high triglycerides - Abnormal remnant-particle metabolism can contribute to complex lipid patterns.
Mixed cholesterol abnormalities - Specialist apolipoprotein testing can add information where several lipid fractions are altered.
A family history of significant dyslipidaemia - Inherited differences in lipid metabolism can prompt more detailed assessment.
Premature cardiovascular disease in the family - Advanced lipid testing may provide additional information beyond routine cholesterol.
A previous abnormal ApoE measurement - Repeat testing can help assess whether the result is persistent.
Discordant standard lipid and ApoB results - Specialist testing can occasionally provide additional context.
A clinician-directed investigation of remnant lipoproteins - ApoE has an important role in remnant clearance.
The need to distinguish ApoE protein testing from ApoE genotype testing - These are different investigations answering different questions.
This test does not determine your APOE genotype.
It should not be used as a standalone Alzheimer's disease risk assessment.
Where inherited APOE variants are the clinical question, the separate Apolipoprotein E Genotype test is required.
How to Book Your Apolipoprotein E Test
The Apolipoprotein E test can be booked privately for specialist fasting assessment of this lipid-transport protein.
Choose the Apolipoprotein E
Select the individual fasting Apolipoprotein E blood test online.
Select your sample collection option
Choose an in-clinic blood draw or professional home or hotel phlebotomy where suitable.
Attend your appointment
Attend after the specified 12-hour fast and a trained healthcare professional will collect the required venous sample.
Laboratory analysis
Your serum undergoes specialist measurement of Apolipoprotein E (12 hours fasting).
Receive your results securely
Your authorised result is delivered securely and can be interpreted alongside cholesterol, Triglycerides, ApoB and other lipid markers where appropriate.
When Will I Receive My Results?
Results are expected approximately 1–2 days after laboratory receipt for Apolipoprotein E testing.
The sample undergoes laboratory apolipoprotein analysis, quality-control procedures and result authorisation.
Turnaround begins when the specimen reaches the laboratory rather than necessarily from the exact time the blood sample is collected.
Specialist repeat analysis can occasionally extend the expected reporting time.
Understanding Your Results
The result shows the concentration of circulating Apolipoprotein E measured under the specified fasting conditions.
The laboratory's own reference interval should be used.
A result outside the reference range does not diagnose a specific lipid disorder by itself.
ApoE concentration can be influenced by lipid metabolism, liver function, inherited factors and other biological variables.
Interpretation is often more useful when the result is considered alongside Total Cholesterol, LDL Cholesterol, HDL Cholesterol and Triglycerides.
Apolipoprotein B provides information about the concentration of atherogenic lipoprotein particles.
Apolipoprotein A1 provides information related to HDL-associated protein.
These markers answer different questions.
ApoE protein concentration should also not be confused with APOE genotype.
A normal or abnormal circulating ApoE result does not tell you whether your inherited genotype is E2, E3 or E4.
Why Book With London Blood Tests?
London Blood Tests provides private access to fasting Apolipoprotein E measurement for specialist lipid and metabolic assessment.
Measures circulating ApoE protein - The test assesses Apolipoprotein E rather than APOE genetic variants.
Relevant to lipid transport - ApoE plays an important role in remnant-particle recognition and clearance.
Can complement ApoB testing - ApoB provides information about the overall burden of atherogenic lipoprotein particles.
Can complement a cholesterol profile - Standard cholesterol and triglyceride measurements provide important additional context.
Clearly distinct from ApoE Genotype - The protein test and genetic test answer different clinical questions.
Professional blood collection - Clinic and suitable home or hotel phlebotomy appointments are available.
Fasting collection conditions - The test is performed following the specified 12-hour fast.
Clear pricing - The Apolipoprotein E test costs £99.
Private Apolipoprotein E Blood Test in London
London Blood Tests provides private Apolipoprotein E testing for people requiring specialist measurement of this lipid-transport protein.
The test costs £99 and measures 1 specialist biomarker: Apolipoprotein E (12 hours fasting).
Results are expected approximately 1–2 days after laboratory receipt.
This is a circulating protein measurement and is separate from the Apolipoprotein E Genotype test used to determine inherited APOE variants.