Apolipoprotein E Genotype
The Apolipoprotein E (ApoE) Genotype Test analyses your DNA to identify genetic variants linked to cholesterol metabolism, cardiovascular health, and Alzheimer’s disease risk.
Turnaround time
6 business days
Biomarkers count
1
Book your test
Choose Service Type
Professional phlebotomist comes to you
+ £{{ home_visit_fee }}
Visit our clinic for your test
{{ clinic_visit_fee > 0 ? '+ £' + clinic_visit_fee : 'Free' }}
Home Visit Details
Home visits require at least 24 hours notice.
Select a clinic: Sorting by distance…
{{ clinicAddress(clinic) }}
{{ clinicAddress(selectedClinic) }}
Select a date
Select an hour
Available time slots: {{ timeSlots.length}}
Overview of the Apolipoprotein E Genotype Test
The Apolipoprotein E Genotype test is a specialist genetic blood test that identifies which common APOE gene variants you carry. The APOE gene provides instructions for producing apolipoprotein E, a protein involved in transporting cholesterol and other fats through the body.
The three common APOE variants are known as E2, E3 and E4. Everyone inherits two copies of the APOE gene, one from each biological parent. The resulting genotype can provide information about inherited differences in lipid metabolism and certain long-term health risks.
This is a single-biomarker genetic test. APOE E4 is associated with an increased risk of late-onset Alzheimer's disease, but carrying E4 does not mean that someone has Alzheimer's disease or will inevitably develop it. APOE results should be interpreted alongside family history, cardiovascular risk factors, lipid results, symptoms where relevant and professional clinical or genetic advice.
What Does the Apolipoprotein E Genotype Test Check ?
This test measures 1 biomarker.
Apolipoprotein E Genotype
Identifies your inherited APOE genotype, commonly involving the E2, E3 and E4 variants. APOE influences the transport and metabolism of cholesterol and other lipids, while certain variants are also associated with differences in long-term cardiovascular and neurological risk. The result reflects inherited genetic information and should be interpreted alongside family history, current health markers and appropriate clinical advice.
Who May Benefit From the Apolipoprotein E Genotype Test?
This test may be suitable for people who want to understand inherited differences in lipid metabolism or obtain additional genetic information relating to cardiovascular and neurological risk.
Investigate a strong family history of Alzheimer's disease – Gain information about APOE variants that may influence susceptibility to late-onset Alzheimer's disease without implying that the condition will develop.
Explore inherited cardiovascular risk – Add genetic information when reviewing long-term heart and vascular health.
Investigate persistently abnormal cholesterol results – Consider whether inherited APOE variation may be relevant alongside current lipid measurements.
Review a family history of premature cardiovascular disease – Add another layer of information where heart disease or stroke has occurred unusually early in close relatives.
Understand their APOE E2, E3 or E4 status – Identify which common APOE variants have been inherited.
Complement advanced cholesterol testing – Use genotype information alongside markers such as ApoB, LDL cholesterol and Lipoprotein (a) rather than relying on genetics alone.
Take a preventative approach to long-term health – Establish inherited information that remains stable throughout life.
Discuss genetic risk with a healthcare professional – Provide laboratory information that can be considered alongside personal and family history.
Arrange a private blood test in London – Access specialist genetic testing through London Blood Tests without waiting for a routine GP referral.
How to Prepare
Relevant clinical and family history may be required for this specialist test. If possible, have details of significant family cardiovascular disease, dementia, previous lipid abnormalities or related investigations available when booking or reviewing your result.
Symptoms and Reasons to Consider the Apolipoprotein E Genotype Test
You may wish to consider the Apolipoprotein E Genotype test if you have a family history, laboratory findings or health concerns that make inherited lipid or neurological risk particularly relevant. APOE genotype itself does not cause a specific set of symptoms.
Family history of late-onset Alzheimer's disease – APOE status may provide additional inherited risk information, although it cannot predict with certainty whether Alzheimer's disease will develop.
Family history of dementia – Genetic information may be useful as part of a wider discussion about neurological risk, depending on the type and pattern of dementia in the family.
Persistently raised cholesterol – APOE variants can influence lipid metabolism and may provide additional context alongside a current lipid profile.
Unusual or difficult-to-explain lipid results – Genetic information may complement laboratory assessment when cholesterol or triglyceride patterns require further review.
Family history of early heart disease – APOE testing may contribute additional inherited information alongside established cardiovascular risk markers.
Family history of stroke – Genetic and lipid-related factors may be considered as part of a broader cardiovascular assessment.
Personal interest in inherited health risk – Some people choose APOE testing to better understand their genetic background and discuss appropriate monitoring with a clinician.
Previous abnormal ApoB or cholesterol results – Genotype information may add context but does not replace measurement of current cardiovascular biomarkers.
Concerns about cognitive changes – APOE testing may provide risk information but does not diagnose Alzheimer's disease or explain cognitive symptoms on its own.
A recommendation from a GP, neurologist, lipid specialist or genetic professional – Testing may be appropriate where APOE status has been requested as part of a wider clinical assessment.
APOE genotype is inherited and remains unchanged throughout life. The E4 variant is associated with an increased probability of developing late-onset Alzheimer's disease, but it is a risk factor rather than a diagnosis. Many people who carry E4 never develop dementia, while many people who develop Alzheimer's disease do not carry E4.
Genetic results can also have implications for biological relatives and may be emotionally significant. Results should be considered alongside medical history, family history, age, current lipid and cardiovascular markers and professional advice. Cognitive symptoms should be assessed clinically rather than attributed to an APOE result alone.
How to Book Your Apolipoprotein E Genotype Test in London
Booking your Apolipoprotein E Genotype test with London Blood Tests is simple and designed to fit around your schedule.
Choose the Apolipoprotein E Genotype
Select the Apolipoprotein E Genotype test online and review the test information before booking.
Select your sample collection option
Choose an in-clinic blood draw (+£35) or a home or hotel phlebotomy visit (+£60) where a qualified phlebotomist collects your sample.
Attend your appointment
A trained professional will collect your blood sample safely and efficiently at the clinic or during your arranged home or hotel visit.
Laboratory analysis
Your sample is sent to the laboratory, where Apolipoprotein E Genotype is analysed to identify your inherited APOE variant.
Receive your results securely
Your results are sent securely by email, ready to review yourself or discuss with a GP, lipid specialist, neurologist, genetic professional or other qualified clinician.
When Will I Receive My Results?
The expected turnaround time for the Apolipoprotein E Genotype test is approximately 6 business days.
Your results are sent securely by email once laboratory analysis and authorisation are complete. Turnaround normally begins when the laboratory receives your sample rather than necessarily from the date your blood is collected.
Genetic investigations occasionally take longer if additional laboratory review or repeat analysis is required. Because an APOE result can have implications for long-term health risk and biological relatives, you may wish to discuss the report with a GP, specialist or genetic professional.
Understanding Your Results
Your report will identify your Apolipoprotein E genotype, based on the common E2, E3 and E4 variants. Because everyone inherits two copies of the APOE gene, results are generally expressed as a combination such as E2/E3, E3/E3 or E3/E4.
An E4 result indicates an increased genetic susceptibility to late-onset Alzheimer's disease, but it does not diagnose Alzheimer's disease and does not mean that dementia will inevitably develop. Similarly, the absence of E4 does not rule out Alzheimer's disease or other forms of dementia.
APOE variants can also influence lipid metabolism, but genotype should not replace current cardiovascular measurements. Results are most useful when considered alongside cholesterol, ApoB, Lipoprotein (a), blood pressure, lifestyle, family history, symptoms and other relevant clinical information. Speak with a GP, neurologist, lipid specialist or genetic professional if you are concerned about your result.
Why Book With London Blood Tests?
Private genetic blood testing in London – Access specialist Apolipoprotein E Genotype testing through London Blood Tests.
Clinic and home visit options – Choose an in-clinic blood draw or request home or hotel phlebotomy depending on location and availability.
Specialist genetic testing – Access targeted testing for inherited health information alongside a wide range of private blood tests.
Secure results by email – Receive your authorised laboratory report securely once genetic analysis is complete.
Clear pricing before booking – The Apolipoprotein E Genotype test is priced at £388, with sample collection fees shown separately.
Convenient appointment process – Arrange private testing around your schedule with flexible collection options.
Support with choosing the right test – London Blood Tests can help if you are unsure whether APOE genotyping or current cardiovascular biomarkers would better suit your needs.
Private testing without a long wait – Access specialist laboratory testing without relying solely on routine referral pathways.
Private Apolipoprotein E Genotype Blood Test in London
London Blood Tests provides private Apolipoprotein E Genotype testing in London for people who want to understand inherited APOE variation and obtain additional information about lipid metabolism and certain long-term health risks.
Clinic appointments are available alongside home and hotel phlebotomy depending on location and availability. Flexible sample collection makes it easier to arrange a private blood test near me while maintaining a discreet and convenient testing process.
The Apolipoprotein E Genotype test provides inherited genetic information rather than a diagnosis of current disease. Results may be useful before discussing cardiovascular risk, family history or neurological concerns with a GP, specialist or genetic professional, particularly when interpreted alongside current blood results and clinical history.