What is the Autoantibody Profile 1 Test?

Autoantibody Profile 1 is a comprehensive blood test that detects a group of autoantibodies associated with systemic and organ-specific autoimmune diseases. Autoantibodies are antibodies produced by the immune system that mistakenly target the body’s own tissues.

This profile includes antibodies linked to thyroid autoimmunity, connective tissue disease, autoimmune liver disorders and autoimmune gastritis. Testing multiple markers together provides a broader view of immune dysregulation than single antibody tests.

The profile is commonly used when autoimmune disease is suspected but symptoms are non-specific or overlap multiple systems.

Why do I need a test for Autoantibody Profile 1?

You may need this test if you have persistent symptoms that cannot be explained by routine blood tests. Autoimmune diseases can affect multiple organs and may present gradually, making early diagnosis challenging.

This profile helps clinicians identify immune-mediated causes of symptoms, guide further investigations and support earlier treatment decisions. It is also useful for monitoring known autoimmune conditions.

Symptoms and scenarios where testing is recommended:

• Unexplained fatigue
• Joint or muscle pain
• Thyroid dysfunction symptoms
• Abnormal liver function tests
• Digestive symptoms or B12 deficiency
• Suspected connective tissue disease
• Family history of autoimmune disease
• Multi-system or unclear symptoms

What’s Tested in Autoantibody Profile 1?

• Thyroid Peroxidase Antibodies (TPO Ab)
• Antinuclear Antibodies (ANA)
• Mitochondrial Antibodies (AMA)
• Smooth Muscle Antibodies (SMA)
• Gastric Parietal Cell Antibodies
• Reticulin Antibodies
• Liver Kidney Microsomal Antibodies (LKM)

Benefits of the Autoantibody Profile 1 Test

• Broad autoimmune screening in one test
  Covers multiple organ systems simultaneously.
• Supports early autoimmune diagnosis
  Helps identify immune dysfunction before advanced disease.
• Evaluates thyroid autoimmunity
  Detects antibodies linked to autoimmune thyroid disease.
• Assesses autoimmune liver conditions
  Includes markers associated with autoimmune hepatitis and PBC.
• Investigates gastrointestinal autoimmunity
  Supports assessment of autoimmune gastritis and malabsorption.
• Identifies connective tissue disease markers
  ANA screening supports rheumatological assessment.
• Guides targeted follow-up testing
  Results help determine next diagnostic steps.
• Reduces diagnostic delay
  Improves clarity when symptoms are multi-system or unclear.

Step-by-Step: How Testing Works

Choose your preferred testing method

You can attend one of our UK partner clinics or arrange a home or hotel visit with a mobile phlebotomist.

Option 1 – In-Clinic Blood Draw

1. Select your nearest UK clinic and book an appointment.
2. A clinician or phlebotomist collects a venous blood sample.
3. The sample is analysed for the full autoantibody panel.
4. Results are delivered securely online.

Option 2 – Home or Hotel Phlebotomy (+£60)

1. Book a UK-wide home or hotel visit at a convenient time.
2. A trained phlebotomist collects your blood sample on-site.
3. The sample is transported to the laboratory.
4. Results are uploaded digitally without the need to travel.

Your Results Explained

Negative Results

No significant autoantibodies detected.
This reduces the likelihood of autoimmune disease but does not fully exclude it.

Low / Borderline Positives

Low-level antibodies may indicate early autoimmune activity or non-specific immune activation.
Clinical correlation and repeat testing may be advised.

Positive Results

Detectable autoantibodies suggest autoimmune involvement.
Results are interpreted based on antibody type, titre and clinical symptoms, and may prompt specialist referral.