Autoantibody Profile 1
This profile screens for multiple clinically relevant autoantibodies in one test. It helps identify autoimmune activity affecting the thyroid, liver, stomach and connective tissues.
Turnaround time
Results available 5 days after arrival in laboratory.
Biomarkers count
5
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Details about Autoantibody Profile 1
What is the Autoantibody Profile 1 Test?
Autoantibody Profile 1 is a comprehensive blood test that detects a group of autoantibodies associated with systemic and organ-specific autoimmune diseases. Autoantibodies are antibodies produced by the immune system that mistakenly target the body’s own tissues.
This profile includes antibodies linked to thyroid autoimmunity, connective tissue disease, autoimmune liver disorders and autoimmune gastritis. Testing multiple markers together provides a broader view of immune dysregulation than single antibody tests.
The profile is commonly used when autoimmune disease is suspected but symptoms are non-specific or overlap multiple systems.
Why do I need a test for Autoantibody Profile 1?
You may need this test if you have persistent symptoms that cannot be explained by routine blood tests. Autoimmune diseases can affect multiple organs and may present gradually, making early diagnosis challenging.
This profile helps clinicians identify immune-mediated causes of symptoms, guide further investigations and support earlier treatment decisions. It is also useful for monitoring known autoimmune conditions.
Symptoms and scenarios where testing is recommended:
- Unexplained fatigue
- Joint or muscle pain
- Thyroid dysfunction symptoms
- Abnormal liver function tests
- Digestive symptoms or B12 deficiency
- Suspected connective tissue disease
- Family history of autoimmune disease
- Multi-system or unclear symptoms
What’s Tested in Autoantibody Profile 1?
- Thyroid Peroxidase Antibodies (TPO Ab)
- Antinuclear Antibodies (ANA)
- Mitochondrial Antibodies (AMA)
- Smooth Muscle Antibodies (SMA)
- Gastric Parietal Cell Antibodies
- Reticulin Antibodies
- Liver Kidney Microsomal Antibodies (LKM)
Benefits of the Autoantibody Profile 1 Test
- Broad autoimmune screening in one test
Covers multiple organ systems simultaneously. - Supports early autoimmune diagnosis
Helps identify immune dysfunction before advanced disease. - Evaluates thyroid autoimmunity
Detects antibodies linked to autoimmune thyroid disease. - Assesses autoimmune liver conditions
Includes markers associated with autoimmune hepatitis and PBC. - Investigates gastrointestinal autoimmunity
Supports assessment of autoimmune gastritis and malabsorption. - Identifies connective tissue disease markers
ANA screening supports rheumatological assessment. - Guides targeted follow-up testing
Results help determine next diagnostic steps. - Reduces diagnostic delay
Improves clarity when symptoms are multi-system or unclear.
Step-by-Step: How Testing Works
Choose your preferred testing method
You can attend one of our UK partner clinics or arrange a home or hotel visit with a mobile phlebotomist.
Option 1 – In-Clinic Blood Draw
- Select your nearest UK clinic and book an appointment.
- A clinician or phlebotomist collects a venous blood sample.
- The sample is analysed for the full autoantibody panel.
- Results are delivered securely online.
Option 2 – Home or Hotel Phlebotomy (+£60)
- Book a UK-wide home or hotel visit at a convenient time.
- A trained phlebotomist collects your blood sample on-site.
- The sample is transported to the laboratory.
- Results are uploaded digitally without the need to travel.
Your Results Explained
Negative Results
No significant autoantibodies detected.
This reduces the likelihood of autoimmune disease but does not fully exclude it.
Low / Borderline Positives
Low-level antibodies may indicate early autoimmune activity or non-specific immune activation.
Clinical correlation and repeat testing may be advised.
Positive Results
Detectable autoantibodies suggest autoimmune involvement.
Results are interpreted based on antibody type, titre and clinical symptoms, and may prompt specialist referral.
How It Works
Simple steps to get your results
Book Online
Choose your test online and book in seconds. Select your preferred clinic location or home visit option.
Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
Take control of your health with London Blood Tests
WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.