What is Bone Screen 2?

Bone Screen 2 is an advanced bone health blood test designed to assess calcium regulation, vitamin status, parathyroid activity, and real-time bone turnover. Unlike basic bone tests, this panel includes specialised markers that show whether bone is being broken down or rebuilt.

This profile includes:

• Urea & Electrolytes
• Calcium and Corrected (Adjusted) Calcium
• Vitamin D (25-OH)
• Phosphate and Magnesium
• Parathyroid Hormone (PTH)
• Total ALP and Bone-specific ALP (B-ALP)
• Osteocalcin, P1NP, CTX (bone turnover markers)
• Liver Function Tests, Albumin, Total Protein
• Creatinine and eGFR

These markers work together to evaluate how well your body maintains bone density, mineral balance, and skeletal strength.

Why do I need Bone Screen 2?

Bone loss and mineral imbalance often occur silently for years before fractures or osteoporosis are detected. This test is recommended when there is risk of bone weakening, calcium imbalance, or hormonal regulation issues.

Reasons for testing include:

• Family history of osteoporosis
• Post-menopause bone health concerns
• Frequent fractures or bone pain
• Vitamin D deficiency
• Thyroid or parathyroid disorders
• Long-term steroid use
• Chronic kidney disease affecting minerals
• Unexplained calcium abnormalities
• Monitoring osteoporosis treatment
• Age-related bone density loss

This test helps detect early bone metabolism problems before structural damage occurs.

Benefits of the test

1. Detects early osteoporosis risk

Bone turnover markers reveal early bone loss.

2. Assesses calcium regulation

PTH, calcium, and Vitamin D show mineral control.

3. Measures active bone formation and breakdown

P1NP, CTX and osteocalcin reflect real-time bone activity.

4. Evaluates Vitamin D status

Critical for calcium absorption and bone strength.

5. Identifies parathyroid disorders

PTH abnormalities strongly affect bone density.

6. Links kidney health to bone health

Creatinine and eGFR show mineral regulation impact.

7. Monitors treatment effectiveness

Useful for tracking osteoporosis therapy.

8. Provides comprehensive bone metabolism picture

Goes beyond standard calcium testing.

Expanded benefit explanation
Bone health depends on hormonal control, mineral balance, kidney function, and active bone turnover. This advanced panel provides a full picture of how bones are maintained and where imbalance may be occurring.

Step-by-step — How testing works

We offer two UK-wide testing options:

Clinic testing
• Choose your nearest UK clinic
• Attend your appointment
• Blood sample collected by clinician
• Sample analysed in laboratory
• Results securely returned

Home or hotel visit (+£60)
• Phlebotomist visits your home or hotel
• Blood sample collected safely
• No need to travel
• Sample transported to lab
• Results delivered confidentially

Both services are available UK-wide.

Your results explained

Low levels

Low Vitamin D, calcium, or bone formation markers may indicate bone weakness.

Typical UK ranges:
• Vitamin D: 50–125 nmol/L
• Adjusted Calcium: 2.2–2.6 mmol/L
• PTH: 1.6–6.9 pmol/L

Low levels may suggest poor bone mineralisation or deficiency.

Normal levels

Mineral balance and bone turnover appear healthy.

Interpretation:
Bone metabolism and calcium regulation are functioning well.

High levels

Elevated markers may indicate bone breakdown or hormonal imbalance.

Possible findings:
• High PTH suggesting parathyroid overactivity
• Raised CTX indicating increased bone breakdown
• Elevated ALP or B-ALP suggesting increased bone turnover
• Abnormal calcium linked to hormonal or kidney causes

Interpretation:
Further medical evaluation may be needed to prevent bone loss.