Calcitonin

Calcitonin Blood Test | London Blood Tests UK

Test calcitonin levels to assess thyroid C-cell activity and screen for medullary thyroid cancer. UKAS-accredited testing for £148.

The Calcitonin Blood Test measures calcitonin, a hormone produced by thyroid C-cells, and is primarily used to screen for and monitor medullary thyroid carcinoma (MTC). Available for £148, analysed in a UKAS-accredited laboratory, with results typically available within 5–7 business days and an optional GP consultation for interpretation.

What is a Calcitonin Blood Test?

Calcitonin is a hormone produced by parafollicular (C) cells of the thyroid gland. Its physiological role is to help regulate calcium metabolism by lowering blood calcium levels, although in adults its role is relatively minor compared to parathyroid hormone and vitamin D.

Clinically, calcitonin is most important as a tumour marker for medullary thyroid carcinoma (MTC), a rare form of thyroid cancer originating from C-cells. Elevated calcitonin levels can indicate the presence of MTC, even in early stages, making this test a valuable screening and monitoring tool.

Calcitonin testing is often requested when:

• A thyroid nodule is detected

• There is a family history of MTC or MEN2 syndrome

• Monitoring known MTC after surgery or treatment

Benefits of the Calcitonin Blood Test

1. Key Marker for Medullary Thyroid Cancer
   Calcitonin is the most sensitive blood marker for detecting MTC.

2. Early Detection of Thyroid C-Cell Disorders
   Elevated levels may identify disease before symptoms develop.

3. Supports Thyroid Nodule Evaluation
   Helps determine whether a thyroid nodule requires urgent specialist review.

4. Essential for Familial Risk Screening
   Recommended for individuals with a family history of MTC or MEN2.

5. Monitors Treatment Response
   Falling levels after surgery suggest successful treatment; rising levels may indicate recurrence.

6. Simple Blood Test
   Requires only a single blood draw with no fasting required.

7. Optional GP Consultation for Interpretation
   Results can be reviewed with a GP to determine urgency and next steps.

Why Do I Need a Calcitonin Blood Test?

You may be advised to have this test if you:

• Have a thyroid nodule detected on examination or imaging

• Have a family history of medullary thyroid cancer

• Are known to carry a MEN2 genetic mutation

• Are being monitored after treatment for MTC

• Have unexplained persistent diarrhoea or flushing (rare MTC symptoms)

Calcitonin testing is not part of routine thyroid screening, but is crucial in specific clinical situations.

How the Test Works

In-Clinic Blood Test

1. Book Your Appointment

   • Book online or by phone; no referral required.

2. Pre-Test Preparation

   • No fasting required.

   • Inform the clinician about proton pump inhibitors or calcium supplements.

3. Blood Sample Collection

   • A qualified phlebotomist collects a venous blood sample.

4. Sample Handling

   • Samples are transported promptly to a UKAS-accredited laboratory.

5. Laboratory Analysis

   • Calcitonin is measured using high-sensitivity immunoassay techniques.

6. Quality Control

   • Strict internal and external quality checks are applied.

7. Results Delivery

   • Results are typically available within 5–7 business days.

8. Optional GP Consultation

   • Review results and referral needs with a GP if required.

At-Home Blood Draw (Home or Hotel Service)

1. Book a Home Visit

   • Choose a convenient UK-wide location.

2. Professional Phlebotomist Visit

   • A certified phlebotomist attends your home or hotel.

3. Blood Collection

   • A venous blood sample is collected safely and professionally.

4. Courier to Laboratory

   • Samples are transported the same day.

5. Analysis & Reporting

   • Calcitonin levels are analysed and verified.

6. Optional GP Review

   • Discuss results with a GP if needed.

Your Calcitonin Test Results – Explained

Calcitonin levels are reported in pg/mL (picograms per millilitre).

Typical UK Reference Ranges

• Men: < 8.4 pg/mL

• Women: < 5.0 pg/mL

Interpretation

• Normal Levels
  Make medullary thyroid carcinoma unlikely.

• Mildly Elevated Levels
  May occur with thyroid nodules, smoking, or certain medications; further evaluation may be needed.

• Markedly Elevated Levels
  Strongly suggestive of MTC and require urgent endocrine referral.

Calcitonin results should always be interpreted alongside thyroid ultrasound and clinical findings.