Calprotectin and Elastase Panel
Private Calprotectin and Elastase stool testing in London for £168, assessing 2 digestive markers with results expected in around 5 days.
Turnaround time
5 business days
Biomarkers count
2
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Overview of the Calprotectin & Elastase Panel
The Calprotectin and Elastase Panel measures two complementary stool biomarkers that assess intestinal inflammation and pancreatic digestive enzyme output.
The panel assesses 2 digestive biomarkers: Calprotectin and Elastase (Faecal).
These markers answer different clinical questions.
Faecal Calprotectin is a protein released predominantly by neutrophils during intestinal inflammation.
When inflammation is present within the bowel, Calprotectin can rise substantially in the stool.
It is widely used to help distinguish inflammatory bowel conditions from functional disorders such as irritable bowel syndrome.
Raised Calprotectin can occur with inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
However, it is not specific to IBD.
Gastrointestinal infection, certain medicines and other inflammatory conditions can also increase the result.
Faecal Elastase provides information about pancreatic exocrine function.
Elastase is a digestive enzyme produced by the pancreas.
It remains relatively stable as it passes through the gastrointestinal tract, allowing its concentration in stool to provide an indirect measure of pancreatic enzyme secretion.
Low faecal Elastase can indicate exocrine pancreatic insufficiency, where the pancreas is not releasing sufficient digestive enzymes.
This can occur with chronic pancreatitis, cystic fibrosis, selected pancreatic disorders and other clinical conditions.
Combining the two markers can be particularly useful where symptoms such as persistent diarrhoea, abdominal discomfort, unexplained weight loss or malabsorption could arise from intestinal inflammation, pancreatic insufficiency or both.
The panel does not diagnose inflammatory bowel disease or pancreatic disease by itself.
Abnormal results may require gastroenterology review, imaging, endoscopy or additional laboratory investigation.
What Does the Calprotectin & Elastase Panel Check?
The panel assesses intestinal inflammatory activity and pancreatic exocrine enzyme output using two stool biomarkers. This test measures 2 specialist biomarkers.
Calprotectin
Measures a neutrophil-derived protein in stool that rises with intestinal inflammation and can support differentiation between inflammatory bowel disease and non-inflammatory gastrointestinal conditions.
Elastase (Faecal)
Measures pancreatic elastase in stool, providing a non-invasive assessment of pancreatic exocrine enzyme production and supporting investigation of exocrine pancreatic insufficiency.
Who May Benefit From the Calprotectin & Elastase Panel?
The combined panel can be useful where persistent digestive symptoms require assessment of both bowel inflammation and pancreatic digestive function.
People with persistent diarrhoea - Both intestinal inflammation and pancreatic insufficiency can contribute to ongoing loose stools.
People with unexplained weight loss and gastrointestinal symptoms - Malabsorption or inflammatory bowel disease can require further investigation.
People with greasy or difficult-to-flush stools - Steatorrhoea can occur when pancreatic digestive enzyme production is inadequate.
People with recurrent abdominal pain or digestive disturbance - The two markers can help investigate different possible mechanisms.
People with suspected inflammatory bowel disease - Calprotectin can provide non-invasive evidence of intestinal inflammation.
People with suspected pancreatic exocrine insufficiency - Faecal Elastase provides information about pancreatic enzyme output.
People with previous abnormal Calprotectin or Elastase results - Repeat testing can help establish whether abnormalities persist.
People advised to undergo stool inflammatory and pancreatic testing - The combined panel can assess both areas from a stool specimen.
How to Prepare
Do not stop prescribed medication solely to alter the stool results unless specifically advised.
A very watery specimen can underestimate Faecal Elastase because of dilution and may need to be repeated on a more formed sample.
Symptoms and Reasons to Consider the Calprotectin & Elastase Panel
The panel is particularly useful where gastrointestinal symptoms could reflect inflammation, malabsorption or reduced pancreatic digestive function.
Persistent or recurrent diarrhoea - Intestinal inflammation and pancreatic insufficiency are both possible causes.
Greasy, pale or difficult-to-flush stools - Fat malabsorption can occur with pancreatic exocrine insufficiency.
Unexplained weight loss - Significant intestinal inflammation or malabsorption can affect body weight.
Persistent abdominal pain - Gastrointestinal and pancreatic disorders can both cause abdominal symptoms.
Bloating with malabsorption concerns - Pancreatic enzyme insufficiency can affect digestion and nutrient absorption.
Blood or mucus in the stool - Intestinal inflammatory disease requires appropriate clinical assessment.
Known inflammatory bowel disease requiring monitoring - Calprotectin can sometimes provide information about current inflammatory activity.
Known pancreatic disease with digestive symptoms - Elastase can help assess whether exocrine pancreatic function is reduced.
Significant rectal bleeding, black stools, severe abdominal pain, persistent vomiting, fever, marked dehydration or rapid unexplained weight loss requires medical assessment.
Calprotectin and Elastase provide useful laboratory information but do not replace endoscopy, imaging or specialist assessment where clinically indicated.
How to Book Your Calprotectin & Elastase Panel in London
The Calprotectin and Elastase Panel can be booked privately for combined stool assessment of intestinal inflammation and pancreatic exocrine function.
Choose the Calprotectin and Elastase Panel
Select the combined stool panel online.
Select your sample collection option
Arrange delivery or collection of the appropriate stool-sample kit.
Attend your appointment
Clinic attendance is not normally required to provide the specimen; collect the stool sample according to the instructions supplied.
Laboratory analysis
Your stool sample undergoes measurement of Calprotectin and Elastase (Faecal).
Receive your results securely
Your authorised results are delivered securely and can be interpreted alongside symptoms and other gastrointestinal investigations.
When Will I Receive My Results?
The specialist laboratory turnaround for the combined Calprotectin and Elastase profile is approximately 5 days after laboratory receipt.
The panel includes two different stool analyses.
Calprotectin assesses intestinal inflammatory activity, while Faecal Elastase requires specialist pancreatic-enzyme measurement.
The sample undergoes laboratory analysis, quality-control procedures and result authorisation.
Turnaround begins when an acceptable stool specimen reaches the laboratory.
Understanding Your Results
The two results should be interpreted separately because they assess different biological processes.
A raised Calprotectin result indicates increased intestinal inflammatory activity.
This can occur with inflammatory bowel disease, gastrointestinal infection and several other inflammatory conditions.
A raised result does not independently diagnose Crohn's disease or ulcerative colitis.
A low Calprotectin result makes significant active intestinal inflammation less likely in the appropriate clinical context.
Faecal Elastase is interpreted differently.
A normal Elastase result generally supports adequate pancreatic exocrine enzyme production.
A reduced Elastase result can indicate pancreatic exocrine insufficiency.
Lower concentrations are generally associated with more significant impairment.
Watery diarrhoeal samples can dilute Elastase and produce an artificially low result.
Where this is suspected, repeat testing on a formed specimen may be necessary.
Abnormal results may lead to additional gastroenterology investigation depending on symptoms and clinical history.
Why Book With London Blood Tests?
London Blood Tests provides private access to two complementary stool markers within one digestive-health panel.
Assesses 2 complementary digestive markers - Calprotectin evaluates intestinal inflammation while Elastase assesses pancreatic enzyme output.
Useful in persistent diarrhoea - The panel investigates two important mechanisms that can contribute to chronic gastrointestinal symptoms.
Supports inflammatory bowel assessment - Calprotectin is widely used as a non-invasive intestinal inflammatory marker.
Supports pancreatic-function assessment - Faecal Elastase provides information about pancreatic exocrine secretion.
Non-invasive stool testing - Both measurements are performed from stool rather than a blood sample.
Specialist laboratory analysis - Samples undergo dedicated gastrointestinal biomarker testing.
Convenient home collection - The specimen can usually be collected privately at home.
Clear pricing - The Calprotectin and Elastase Panel costs £168.
Private Calprotectin & Elastase Panel Blood Test in London
At London Blood Tests, we provide private Calprotectin & Elastase Panel testing through accredited laboratories, giving you access to comprehensive digestive health assessment.
Our service offers convenient clinic support and flexible testing options, allowing you to arrange a private test near you with clear instructions and secure laboratory reporting.
Whether you are investigating digestive symptoms, monitoring gastrointestinal health or obtaining laboratory information before speaking with your GP or specialist, our service provides reliable testing, discreet reporting and convenient access to specialist investigations.