What is the Ceruloplasmin Blood Test?

The Ceruloplasmin blood test measures the concentration of ceruloplasmin, a copper-binding protein produced by the liver. Ceruloplasmin plays a key role in transporting copper in the bloodstream and regulating copper balance in the body.

Copper is an essential trace element, but abnormal copper metabolism can lead to toxic accumulation or deficiency, affecting the liver, brain and nervous system. Ceruloplasmin levels provide important insight into how copper is being handled by the body.

This test is most commonly used in the investigation of Wilson’s disease, but it can also support assessment of liver disease, inflammation and certain neurological conditions.

Why do I need a Ceruloplasmin Blood Test?

A ceruloplasmin blood test is recommended when there is suspicion of abnormal copper metabolism or unexplained liver or neurological symptoms. It helps identify whether low or high ceruloplasmin levels may be contributing to disease.

You may benefit from this test if you have:

• Unexplained liver disease or abnormal liver enzymes
• Symptoms suggestive of Wilson’s disease
• Neurological symptoms such as tremor or coordination problems
• Psychiatric or behavioural changes without clear cause
• Kayser–Fleischer rings detected on eye examination
• Family history of Wilson’s disease
• Unexplained anaemia
• Chronic inflammation or infection
• Suspected copper deficiency or excess

Early detection is essential, particularly for Wilson’s disease, as treatment can prevent serious organ damage.

Benefits of the Ceruloplasmin Blood Test

• Key marker for copper metabolism
  Provides insight into copper transport and balance.
• Essential for Wilson’s disease investigation
  One of the core screening tests.
• Supports liver disease assessment
  Helps differentiate causes of liver dysfunction.
• Useful in neurological symptom evaluation
  Copper imbalance can affect brain function.
• Simple blood test
  Quick and minimally invasive.
• Guides further diagnostic testing
  Helps determine need for copper studies or imaging.
• Supports early diagnosis
  Enables early intervention before complications develop.
• Relevant for inherited conditions
  Useful for family screening when indicated.

Step-by-Step – How the Test is Performed

• Book your blood test appointment online
• Attend your chosen UK clinic
• A healthcare professional collects a blood sample
• The procedure takes only a few minutes
• Results are reviewed once available

Optional home blood collection may be available in selected areas.

Your Ceruloplasmin Results Explained

Ceruloplasmin results are interpreted using UK laboratory reference ranges and clinical context.

Low Ceruloplasmin Levels

What this means:

• Ceruloplasmin below the reference range

Possible implications:

• Wilson’s disease
• Copper deficiency
• Severe liver disease
• Malnutrition or malabsorption

Low levels often require further copper studies.

Normal Ceruloplasmin Levels

What this means:

• Ceruloplasmin within the reference range

What it suggests:

• Normal copper transport and metabolism.

High Ceruloplasmin Levels

What this means:

• Ceruloplasmin above the reference range

Possible implications:

• Inflammation or infection
• Pregnancy
• Oestrogen use
• Certain liver conditions

Ceruloplasmin is an acute-phase protein, meaning levels can rise with inflammation.