Clostridium Difficile Toxin by PCR
The C. difficile Toxin PCR test detects toxin-producing strains of Clostridium difficile. It helps confirm infection in patients with diarrhoea and gut symptoms.
Turnaround time
3 days
Biomarkers count
1
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Details about Clostridium Difficile Toxin by PCR
What is the Clostridium difficile Toxin by PCR test?
The Clostridium difficile Toxin PCR test is a molecular stool test that detects the presence of toxin-producing genes (toxA/toxB) from Clostridium difficile. PCR (Polymerase Chain Reaction) technology amplifies bacterial DNA, making this test highly sensitive and specific.
Unlike culture alone, PCR confirms whether the strain present is capable of producing toxins that cause intestinal inflammation and colitis. This distinction is crucial, as some individuals may carry non-toxin-producing strains without symptoms.
The test is widely used in hospitals and specialist clinics for the rapid diagnosis of C. difficile infection (CDI).
Why do I need a C. difficile Toxin PCR test?
C. difficile infection can range from mild diarrhoea to severe, life-threatening colitis. Early and accurate diagnosis is essential for prompt treatment and infection control.
You may need this test if you:
- Have persistent or severe diarrhoea
- Developed diarrhoea after antibiotic use
- Have diarrhoea during or after hospital stay
- Have abdominal pain or cramping
- Have fever with gastrointestinal symptoms
- Have suspected antibiotic-associated colitis
- Have recurrent diarrhoea after prior C. difficile infection
Common symptoms of C. difficile infection include:
- Watery diarrhoea
- Abdominal pain or tenderness
- Fever
- Nausea
- Dehydration
- Fatigue
Benefits of the C. difficile Toxin PCR test
- Highly sensitive and specific
Detects toxin-producing strains accurately. - Rapid diagnosis
Faster than traditional culture methods. - Confirms toxin production
Differentiates infection from harmless colonisation. - Supports early treatment decisions
Enables prompt clinical intervention. - Clinically recognised diagnostic method
Used in NHS and private laboratories. - Non-invasive sample
Requires only a stool sample. - Useful in recurrent infection monitoring
Helps assess relapse or reinfection. - Supports infection control
Reduces spread in healthcare settings.
Step by step – how the test works
You can access C. difficile PCR testing UK-wide through two options:
- Clinic appointment
Collect a stool sample using the provided container and return it to your nearest clinic. - At-home testing
Collect your stool sample at home following clear instructions and return it using secure packaging.
The sample is analysed in an accredited UK laboratory using PCR technology, and results are delivered securely.
Your results explained
Negative result
No toxin-producing C. difficile detected. Symptoms may be due to another cause.
Typical UK interpretation:
- C. difficile toxin genes not detected
Positive result
Toxin-producing C. difficile detected, consistent with active infection when symptoms are present.
Typical UK interpretation:
- C. difficile toxin genes detected
Clinical correlation required
A positive result must be interpreted alongside symptoms, as some individuals may carry the bacteria without disease.
Results should always be reviewed by a clinician.
How It Works
Simple steps to get your results
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Choose your test online and book in seconds. Select your preferred clinic location or home visit option.
Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
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WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.