Coagulation Screen
Private Coagulation Screen in London for £174, checking four major clotting markers from a specialist citrate blood sample.
Turnaround time
1 business day
Biomarkers count
4
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Overview of the Coagulation Screen
The Coagulation Screen is a four-marker blood test designed to assess several major pathways involved in normal blood-clot formation.
The test contains 4 biomarkers: Fibrinogen, Inter norm ratio, Prothrombin Time and Partial Thromboplastin Time.
Normal haemostasis depends on platelets, blood-vessel function and a coordinated series of coagulation proteins known as clotting factors.
Prothrombin Time assesses the extrinsic and common pathways of the coagulation cascade.
The Inter norm ratio standardises Prothrombin Time and is particularly important when monitoring Warfarin.
Partial Thromboplastin Time assesses different portions of the intrinsic and common coagulation pathways and is commonly referred to clinically as APTT.
Fibrinogen is the soluble clotting protein converted into Fibrin during the final stages of clot formation.
Abnormal results can occur because of anticoagulant medication, liver disease, inherited or acquired clotting-factor abnormalities and several other conditions.
A normal routine Coagulation Screen does not rule out every bleeding disorder, because platelet-function problems and some mild factor deficiencies can occur despite relatively normal PT and APTT.
What Does the Coagulation Screen Check?
The profile assesses clotting time through two major coagulation pathways together with Fibrinogen, providing a useful first-line overview of blood-clotting function. This test measures 4 biomarkers.
Fibrinogen
Measures the soluble clotting protein converted into Fibrin during formation of a stable blood clot.
Inter norm ratio
Provides a standardised expression of Prothrombin Time and is particularly important when monitoring Warfarin therapy.
Prothrombin Time
Measures clot formation through the extrinsic and common coagulation pathways.
Partial Thromboplastin Time
Measures clot formation through the intrinsic and common coagulation pathways and is commonly reported as APTT.
Who May Benefit From the Coagulation Screen?
This profile may be useful when abnormal bleeding, anticoagulant treatment, liver-related clotting problems or a previous abnormal coagulation result requires investigation.
People with unexplained prolonged bleeding - Abnormal coagulation-factor activity can lengthen clotting times.
People with frequent significant nosebleeds - A broader bleeding assessment may be appropriate where symptoms are recurrent.
People with excessive bleeding after dental work or surgery - Coagulation testing may form part of the investigation.
People with unexpectedly heavy menstrual bleeding and suspected bleeding disorder - Routine clotting tests can provide initial information.
People taking Warfarin - INR is central to monitoring the anticoagulant effect of Warfarin.
People with suspected liver-related coagulation abnormalities - The liver produces many of the proteins required for clotting.
People with a previous prolonged Prothrombin Time or APTT - Repeat testing can determine whether the abnormality persists.
People undergoing selected pre-operative investigations - Coagulation testing may be requested according to the procedure and clinical history.
How to Prepare
Accurate coagulation testing depends not only on the patient but also on correct citrate-tube filling and prompt sample handling, making collection conditions particularly important.
Do not stop anticoagulant medication independently for the purpose of obtaining a different result.
Incorrect citrate filling, clotting within the specimen or excessive transport delay can invalidate coagulation testing and require recollection.
Symptoms and Reasons to Consider the Coagulation Screen Test
Clotting-factor abnormalities can cause abnormal bleeding, although the severity and pattern depend on which part of haemostasis is affected.
Unexplained prolonged bleeding from cuts - Reduced coagulation-factor activity can delay formation of a stable clot.
Frequent or severe nosebleeds - Recurrent epistaxis can prompt broader bleeding assessment.
Easy bruising with other bleeding symptoms - Coagulation abnormalities are one possible cause.
Heavy menstrual bleeding - Significant bleeding can occur with several inherited and acquired haemostatic disorders.
Excessive bleeding after surgery or dental procedures - A history of disproportionate bleeding can indicate an underlying haemostatic problem.
A previous unexplained prolonged PT or APTT - Repeat testing can determine whether the change remains present.
Unexpected bleeding while taking anticoagulants - Medication effect and clotting results may need clinical review.
Severe uncontrolled bleeding, vomiting blood, black stools, significant head injury while anticoagulated or other major haemorrhage requires urgent medical assessment.
Routine outpatient testing should not delay emergency treatment.
How to Book Your Coagulation Screen
Because the Coagulation Screen requires a correctly collected citrate specimen, the sample should be taken through a collection pathway capable of meeting the laboratory's handling requirements.
Choose the Coagulation Screen
Select the four-marker clotting profile online.
Select your sample collection option
Choose a clinic or professional collection route capable of prompt citrate-sample transport.
Attend your appointment
A trained healthcare professional fills the required citrate tube accurately and records relevant medication information.
Laboratory analysis
Prothrombin Time, Inter norm ratio, Partial Thromboplastin Time and Fibrinogen are analysed.
Receive your results securely
Your authorised coagulation report is delivered securely for review.
When Will I Receive My Results?
Routine Coagulation Screen results are generally expected within approximately 1 business day after a suitable citrate sample reaches the laboratory.
PT, INR, APTT and Fibrinogen are commonly processed coagulation investigations, but specimen quality and transport are especially important.
The sample must arrive in suitable condition before reliable analysis can be performed.
An underfilled citrate tube, clotted specimen or excessive transport delay may prevent analysis and require a new blood sample.
Where a screening test is significantly abnormal, additional specialist coagulation investigations may subsequently be required and will have separate turnaround times.
Understanding Your Results
The four markers provide information about different parts of the coagulation system and should be interpreted together.
A prolonged Prothrombin Time or increased INR indicates slower clot formation through PT-sensitive pathways.
Warfarin intentionally increases PT and INR, so interpretation in patients taking Warfarin depends on the therapeutic target prescribed for the relevant condition.
A prolonged Partial Thromboplastin Time can occur with Heparin, Lupus Anticoagulant and selected coagulation-factor deficiencies.
Low Fibrinogen can impair stable clot formation.
Fibrinogen can also increase during infection and inflammation because it behaves as an acute-phase protein.
An abnormal screening result does not identify the exact clotting-factor problem by itself.
Further tests may include individual factor assays, mixing studies, Lupus Anticoagulant testing or Von Willebrand investigations depending on the pattern.
Why Book With London Blood Tests?
This profile provides a focused first-line assessment of major coagulation pathways using four commonly requested clotting markers.
Four key clotting markers - PT, INR, APTT and Fibrinogen are assessed together.
Useful in bleeding assessment - Several important coagulation pathways are screened.
Relevant to Warfarin monitoring - INR provides a standardised measure of Warfarin anticoagulant effect.
Useful after previous abnormal clotting results - Repeat testing can determine whether abnormalities persist.
Specialist citrate collection - Correct specimen handling can be arranged.
Private testing in London - Professional phlebotomy options are available.
Secure reporting - Receive your authorised laboratory report confidentially.
Clear pricing - The Coagulation Screen costs £174.
Private Coagulation Screen Blood Test in London
London Blood Tests provides private Coagulation Screen testing in London for people requiring assessment of routine clotting pathways or follow-up of abnormal coagulation results.
The test costs £174 and contains 4 biomarkers.
Routine results are generally expected within approximately 1 business day of a suitable citrate specimen reaching the laboratory.
The result should always be interpreted alongside bleeding history, medication and other relevant laboratory findings.