Coeliac/Gluten Sensitivity Profile
A six-marker coeliac and gluten sensitivity blood profile assessing key antibodies and Total IgA while you are still consuming gluten.
Turnaround time
3 business days
Biomarkers count
6
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Overview of the Coeliac/Gluten Sensitivity Profile Test
The Coeliac/Gluten Sensitivity Profile is a six-marker blood test assessing immune responses associated with coeliac disease and gluten-related antibodies.
The profile includes Tissue Transglutaminase IgA, Endomysial Antibodies IgA, Gliadin IgA, Gliadin IgG, Reticulin IgA and Total IgA.
Coeliac disease is an autoimmune condition in which gluten exposure triggers an immune response that can damage the lining of the small intestine.
The antibody profile is most informative while gluten is still being consumed.
Removing gluten before testing can lower antibody concentrations and potentially produce a false-negative result.
Total IgA is included because IgA deficiency can affect the reliability of several IgA-based coeliac antibody measurements.
The Coeliac/Gluten Sensitivity Profile costs £299.
What Does the Coeliac/Gluten Sensitivity Profile Test Check?
This test measures 6 biomarkers.
Endomysial Antibodies IgA
Detects IgA antibodies directed against endomysial targets and is highly relevant to coeliac-disease assessment.
Gliadin IgA
Measures IgA antibodies associated with immune response to Gliadin.
Gliadin IgG
Measures IgG antibodies associated with immune response to Gliadin.
Reticulin IgA
Measures IgA antibodies against reticulin-related tissue targets.
Tissue Transglutaminase IgA
Measures tTG IgA, one of the principal serological markers used in coeliac-disease investigation.
Total IgA
Measures total Immunoglobulin A to help determine whether IgA-based coeliac tests can be interpreted reliably.
Who May Benefit From the Coeliac/Gluten Sensitivity Profile Test?
The profile may be useful for people experiencing symptoms or laboratory abnormalities that could be associated with coeliac disease.
People with persistent diarrhoea or constipation - Coeliac disease can produce varied bowel symptoms.
People with bloating or abdominal discomfort - Gastrointestinal symptoms may warrant investigation.
People with unexplained Iron deficiency - Malabsorption can contribute to reduced Iron stores.
People with unexplained nutritional deficiencies - Coeliac disease can impair nutrient absorption.
People with a family history of coeliac disease - First-degree relatives have increased risk.
People with another autoimmune condition - Coeliac disease is more common in some autoimmune populations.
People with persistent symptoms after eating gluten-containing foods - Serological testing may form part of appropriate assessment
How to Prepare
Reducing or eliminating gluten can lower antibody concentrations and potentially make results falsely reassuring.
If you are already gluten-free, the Genetic Coeliac Disease Test may provide useful complementary information.
Symptoms and Reasons to Consider the Coeliac/Gluten Sensitivity Profile Test
Coeliac disease can present with gastrointestinal or non-gastrointestinal symptoms.
Persistent diarrhoea - A common gastrointestinal presentation.
Bloating or abdominal pain - Frequently reported but non-specific symptoms.
Unexplained weight loss - May occur when nutrient absorption is impaired.
Iron-deficiency anaemia - Can sometimes be the presenting feature.
Persistent fatigue - May occur secondary to anaemia, malabsorption or other factors.
Vitamin or mineral deficiencies - Reduced intestinal absorption may affect several nutrients.
Dermatitis herpetiformis or other relevant skin symptoms - Can be associated with coeliac disease.
Family history of confirmed coeliac disease - Genetic susceptibility can cluster within families.
Severe weight loss, persistent gastrointestinal bleeding or significant anaemia requires medical assessment.
Coeliac serology supports investigation but diagnosis may require gastroenterology review and, in some cases, intestinal biopsy.
How to Book Your Coeliac/Gluten Sensitivity Profile
The Coeliac/Gluten Sensitivity Profile can be booked as a private venous blood test.
Choose the Coeliac/Gluten Sensitivity Profile
Select the £299 six-marker profile.
Select your sample collection option
Choose in-clinic phlebotomy (+£35) or a home visit from a phlebotomist (+£60).
Attend your appointment
A trained healthcare professional collects the blood sample.
Laboratory analysis
The six coeliac and gluten-related immune markers are analysed.
Receive your results securely
Your completed serology profile is returned securely.
When Will I Receive My Results?
Results are generally expected within approximately 3 days.
Results are sent securely by email once specialist laboratory analysis and authorisation are complete. Turnaround generally begins when the laboratory receives your blood sample rather than necessarily from the time it is collected.
Understanding Your Results
A positive Tissue Transglutaminase IgA or Endomysial IgA result can provide strong evidence supporting further investigation for coeliac disease.
Gliadin antibody findings may provide additional information but should not be interpreted alone.
Total IgA is important because IgA deficiency can make IgA-based antibody tests less reliable.
Negative results are most meaningful when adequate gluten has been consumed before testing.
Where serology strongly suggests coeliac disease, specialist gastroenterology assessment may be recommended.
Why Book With London Blood Tests?
London Blood Tests provides broad coeliac serology rather than relying on a single antibody measurement.
Six immune markers - Multiple coeliac and gluten-related antibodies are assessed.
tTG IgA included - A principal coeliac serology marker forms part of the profile.
Endomysial IgA included - A highly relevant antibody test is incorporated.
Gliadin IgA and IgG included - Both antibody classes are measured.
Total IgA included - This helps identify situations where IgA-based testing may be unreliable.
Approximately 3-day turnaround - Results are available relatively quickly.
Clear pricing - The Coeliac/Gluten Sensitivity Profile costs £299.
Private Coeliac/Gluten Sensitivity Profile Blood Test in London
London Blood Tests provides the Coeliac/Gluten Sensitivity Profile for £299.
The test measures six immune markers associated with coeliac and gluten-related assessment.
Patients should normally continue consuming gluten before testing.
Results are generally expected within approximately three days.