What is the Dengue Virus Serology test?

The Dengue Virus Serology blood test detects antibodies (IgM and IgG) produced by the immune system in response to infection with the Dengue virus, a mosquito-borne virus common in tropical and subtropical regions.

This test does not detect the virus itself but instead identifies the body’s immune response, making it particularly useful once symptoms have been present for several days or when confirming previous exposure. It is commonly used alongside clinical assessment in patients with unexplained fever after travel.

Dengue serology plays an important role in differentiating Dengue from other viral illnesses such as Zika, Chikungunya, or viral flu-like infections.

Why do I need a Dengue Virus Serology test?

Dengue infection can range from a mild flu-like illness to more severe disease, including Dengue haemorrhagic fever. Early identification helps guide monitoring, follow-up, and exclusion of other serious infections.

This test is especially relevant if you have recently travelled to areas where Dengue is endemic and developed symptoms after returning to the UK.

You may need a Dengue Virus Serology test if you have:

• Recent travel to tropical or subtropical regions
• Persistent or high fever
• Severe headache or pain behind the eyes
• Muscle and joint pain (“breakbone fever”)
• Rash
• Nausea or vomiting
• Unexplained low platelet count
• Symptoms not explained by routine blood tests

Benefits of the Dengue Virus Serology test

• Confirms Dengue exposure
  Identifies immune response to Dengue virus infection.
• Distinguishes recent vs past infection
  IgM and IgG patterns help clarify timing.
• Supports diagnosis after travel
  Particularly useful for returning travellers with fever.
• Helps rule out other infections
  Aids differential diagnosis alongside clinical findings.
• Guides monitoring and follow-up
  Important for identifying patients needing closer observation.
• Non-invasive and reliable
  Requires a simple blood sample.
• Useful when PCR is no longer effective
  Antibodies remain detectable after the acute phase.
• Supports clinical decision-making
  Helps clinicians manage care safely and appropriately.

Step by step – how the test works

You can choose one of two UK-wide testing options:

1. Clinic appointment
   Select your nearest UK clinic. A healthcare professional will collect your blood sample during your visit.
2. At-home or hotel visit (£60 extra)
   A qualified phlebotomist visits your home or hotel to take the sample, so you don’t need to travel.

Your sample is analysed in a UK laboratory, and results are delivered securely once ready.

Your results explained

Negative (Low antibody levels)

Indicates no detectable Dengue antibodies. This may mean no prior exposure or that testing was performed too early for antibodies to develop.

Typical UK interpretation:

• IgM: Negative
• IgG: Negative

Positive IgM (Recent infection)

Suggests a recent or current Dengue infection. IgM antibodies usually appear within days of symptom onset.

Typical UK interpretation:

• IgM: Positive
• IgG: Negative or low

Positive IgG (Past infection)

Indicates previous exposure or infection with Dengue virus. IgG antibodies can persist for years.

Typical UK interpretation:

• IgM: Negative
• IgG: Positive

Note: Exact reference ranges and interpretations may vary by laboratory and clinical context.