Genetic Coeliac Disease Test
A two-marker genetic coeliac profile assessing HLA-DQ2/DQ8 genotype and HLA-DQ2.5 to evaluate genetic susceptibility to coeliac disease.
Turnaround time
10 business days
Biomarkers count
2
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Overview of the Genetic Coeliac Disease Test
The Genetic Coeliac Disease Test is a two-marker genetic profile assessing HLA variants associated with susceptibility to coeliac disease.
The test assesses HLA-DQ2/DQ8 genotype together with HLA-DQ2.5.
Coeliac disease has a strong genetic association with particular HLA types.
However, carrying a susceptible HLA genotype does not mean that a person has coeliac disease or will necessarily develop it.
Many people carry an associated HLA type without ever developing the condition.
Genetic testing is particularly useful for assessing whether coeliac disease is genetically plausible and can also be performed when a person is already following a gluten-free diet.
Unlike coeliac antibody testing, the genetic result is not changed by whether gluten is currently being eaten.
The Genetic Coeliac Disease Test costs £199.
What Does the Genetic Coeliac Disease Test Check?
This test measures 2 genetic biomarkers.
Coeliac Disease - HLA DQ2/DQ8 Genotype
Assesses HLA-DQ2 and HLA-DQ8 genetic susceptibility associated with coeliac disease.
HLA-DQ2.5
Assesses the HLA-DQ2.5 susceptibility marker associated with coeliac disease risk.
Who May Benefit From the Genetic Coeliac Disease Test?
The test may be useful where coeliac disease is being considered but standard antibody testing is difficult to interpret or additional genetic information is needed.
People already following a gluten-free diet - Genetic testing is unaffected by current gluten intake.
People with negative or unclear coeliac antibody results - HLA testing may help assess genetic susceptibility.
People with a family history of coeliac disease - Genetic information may be relevant.
People with long-standing gastrointestinal symptoms - Testing can form one part of a wider assessment.
People who do not want to reintroduce gluten solely for antibody testing - Genetics does not require gluten exposure.
People advised by a gastroenterologist to undergo HLA testing - The result may help clarify diagnostic probability.
How to Prepare
Your HLA genotype does not change when you modify your diet.
This makes genetic testing useful where gluten has already been removed.
Symptoms and Reasons to Consider the Genetic Coeliac Disease Test
Genetic testing is generally prompted by diagnostic uncertainty or family history rather than a specific symptom.
Persistent diarrhoea or bloating - These may warrant coeliac assessment among other investigations.
Unexplained Iron deficiency - Coeliac disease can affect nutrient absorption.
A first-degree relative with coeliac disease - Family history increases genetic relevance.
Symptoms improve on a gluten-free diet - Genetics can be assessed even after gluten has been removed.
Previous inconclusive antibody testing - HLA testing can provide additional information.
Difficulty completing a gluten challenge - Genetic testing does not depend on ongoing gluten consumption.
A positive genetic result does not diagnose coeliac disease.
It indicates genetic susceptibility and must be interpreted alongside symptoms, serology and, where appropriate, gastroenterology assessment.
How to Book Your Genetic Coeliac Disease Test
The Genetic Coeliac Disease Test can be arranged through the specialist genetics pathway.
Choose the Genetic Coeliac Disease Test
Select the £199 two-marker genetic profile.
Select your sample collection option
Choose in-clinic phlebotomy (+£35) or a home visit from a phlebotomist (+£60).
Attend your appointment
The genetic specimen is collected.
Laboratory analysis
HLA-DQ2/DQ8 genotype and HLA-DQ2.5 susceptibility markers are assessed.
Receive your results securely
Your authorised genetic report is delivered securely.
When Will I Receive My Results?
Results are generally expected within approximately 10 days.
Results are sent securely by email once specialist laboratory analysis and authorisation are complete. Turnaround generally begins when the laboratory receives your blood sample rather than necessarily from the time it is collected.
Understanding Your Results
A susceptibility-associated HLA result means the genetic background compatible with coeliac disease is present.
It does not diagnose active coeliac disease.
Many people carrying an associated genotype never develop the condition.
A result without the major recognised susceptibility types makes coeliac disease substantially less likely, although interpretation should remain laboratory and clinically specific.
Where symptoms remain concerning, other gastrointestinal investigations may still be required.
Why Book With London Blood Tests?
London Blood Tests provides focused genetic assessment for coeliac susceptibility.
Two genetic biomarkers - The page has been simplified to the two required markers.
HLA-DQ2/DQ8 assessed - Major coeliac-associated genetic susceptibility is evaluated.
HLA-DQ2.5 included - An important susceptibility marker forms part of the profile.
No gluten challenge required - The genetic result is unaffected by diet.
Specialist genetic laboratory processing - The sample follows the appropriate genetics pathway.
Approximately 10-day turnaround - Results are generally expected within the stated timeframe.
Clear pricing - The Genetic Coeliac Disease Test costs £199.
Private Genetic Coeliac Disease Test in London
London Blood Tests provides the Genetic Coeliac Disease Test for £199.
The profile contains two genetic markers assessing HLA susceptibility associated with coeliac disease.
Results are generally expected within approximately ten days.