1,25-dihydroxyvitamin D (calcitriol)
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Genetic Familial Hypercholesterolaemia Risk
600.00
This test identifies genetic variants associated with familial hypercholesterolaemia, a condition causing very high cholesterol levels from a young age. Early detection helps reduce long-term cardiovascular risk through timely treatment and monitoring.
Turnaround time
4-6 weeks
Biomarkers count
5
Same-Day Appointments
UKAS Accredited Labs
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Under 18? Patients under 18 can only be seen at GB Medlabs and Clinilabs, Monday to Friday only.
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Details about Genetic Familial Hypercholesterolaemia Risk
Genetic Familial Hypercholesterolaemia | London Blood Tests |
At London Blood Tests, we offer advanced genetic testing services to help you understand and manage your health risks. Our Genetic Familial Hypercholesterolaemia (FH) Risk Test screens for genetic variants associated with FH, a condition characterized by high cholesterol levels that can lead to cardiovascular diseases. This test provides critical insights into your genetic predisposition, allowing you to take preventive measures and manage your health proactively.
What is it?
Our Genetic Familial Hypercholesterolaemia Risk Test screens and detects genetic variants in five genes (APOB, APOE, LDLR, LDLRAP1, and PCSK9) that may increase the risk of developing FH. This comprehensive test helps identify individuals at risk of high cholesterol and associated complications.
1. APOB: Encodes a protein essential for forming LDL ("bad cholesterol"). Mutations can lead to high cholesterol and heart disease.
2. APOE: Involved in fat metabolism. Different versions of this gene affect the risk of Alzheimer's and heart disease, especially the APOE4 variant.
3. LDLR: Produces the LDL receptor, which removes LDL cholesterol from the blood. Mutations cause high cholesterol and increase heart disease risk.
4. LDLRAP1: Helps the LDL receptor work properly, especially in the liver. Mutations can lead to a condition like familial hypercholesterolemia, but usually less severe.
5. PCSK9: Regulates the number of LDL receptors. Mutations can either increase or decrease cholesterol levels, affecting heart disease risk.
Benefits
• Accurate Risk Assessment: Identify your genetic predisposition to FH and high cholesterol levels.
• Preventive Health Management: Take informed steps to manage cholesterol levels and reduce cardiovascular risk.
• Comprehensive Analysis: Understand your genetic profile with a detailed report and recommendations.
• Quick Turnaround: Receive your results within 6 weeks, allowing for timely medical advice and action.
The Process
• Book an Appointment: Schedule your test online or via phone.
• Sample Collection: Visit our clinic for a blood sample collection or arrange a home visit for an additional £60.
• Laboratory Analysis: Our expert team analyzes your sample for genetic variants in APOB, APOE, LDLR, LDLRAP1, and PCSK9.
• Receive Results: Get your results within 6 weeks, complete with a detailed report and personalized recommendations.
Why Choose London Blood Tests?
• Experienced Professionals: Our team of specialists ensures precise and reliable testing.
• Convenient Locations: Easily accessible clinics across London.
• Comprehensive Support: From booking to results, we provide support at every step.
Ideal For
• Adults with unexplained high total cholesterol levels (>7.5 mmol/l) or high LDL-C levels (>4.9 mmol/l).
• Individuals with a first or second-degree relative with a history of premature myocardial infarction (MI).
• Anyone seeking to understand their genetic risk for high cholesterol and cardiovascular diseases.
How to Get Started
1. Schedule Your Test: Book online or call us to arrange your test.
2. Choose Your Collection Method: Decide between a clinic visit or a home visit for an additional fee.
3. Prepare for the Test: Follow any pre-test instructions provided.
4. Get Tested: Visit the clinic or have a professional come to your home to collect your sample.
5. Receive Your Results: We will send your results via email within 6 weeks.
Understanding your genetic risk for familial hypercholesterolaemia can significantly improve your ability to manage cholesterol levels and prevent cardiovascular diseases. At London Blood Tests, we offer a comprehensive and reliable Genetic FH Risk Test to help you take control of your health. Book your test today and take the first step towards proactive health management.
How It Works
Simple steps to get your results
1
Book Online
Choose your test online and book in seconds. Select your preferred clinic location or home visit option.
2
Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
3
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
Take control of your health with London Blood Tests
WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.
Frequently Asked Questions
Yes, if a pathogenic mutation is identified.
It answers a different question — inherited cause rather than current levels.
No. Medications do not affect genetic results.
Yes. Your genetic profile does not change.
Yes. Early testing enables early prevention.
Yes. Cascade testing is strongly recommended.
Yes. At-home phlebotomy is available across the UK.
Testing is performed in UKAS-accredited laboratories using clinical-grade sequencing.
Results are usually available within 14–21 business days.
A GP consultation is optional, but strongly recommended for positive results.
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