Understanding the Hepatitis A, B & C Profile blood test

The Hepatitis A, B & C Profile is a comprehensive blood test designed to evaluate exposure, immunity, and active infection across the three most common viral hepatitis types, while also assessing liver function.

Rather than testing individual markers separately, this profile combines antibody tests, antigen tests, and liver enzymes to give a clear, clinically meaningful overview of hepatitis status and its impact on the liver.

This profile includes the following markers:

• Hepatitis A Immunity (IgG/IgM)
• Hepatitis A IgM antibodies
• Hepatitis B Surface Antigen
• Hepatitis B Surface Antibodies (Immunity)
• Hepatitis B Core IgG/IgM antibodies
• Hepatitis C Antibodies
• Hepatitis C Antigen
• Liver Function Tests (LFTs)

Together, these markers allow differentiation between acute infection, chronic infection, past exposure, vaccination-related immunity, and no infection, while also showing whether the liver is being affected.

When a Hepatitis A, B & C Profile blood test is recommended

This test is recommended whenever a broad and definitive hepatitis assessment is required. Viral hepatitis can remain asymptomatic for long periods, particularly Hepatitis B and C, making comprehensive blood testing essential.

The profile is commonly used for screening, diagnosis, occupational health, travel medicine, and investigation of abnormal liver blood results.

Testing may be appropriate if you:

• Have abnormal liver function test results
• Have symptoms suggestive of viral hepatitis
• Have been exposed to blood or bodily fluids
• Have a sexual partner with viral hepatitis
• Require occupational, visa, or insurance screening
• Have travelled to higher-risk regions
• Want a full hepatitis health check
• Are undergoing baseline or pre-treatment assessment

Benefits of the Hepatitis A, B & C Profile test

• Complete hepatitis screening in one test
  Covers Hepatitis A, B, and C together.
• Identifies active, past, or resolved infection
  Uses both antibody and antigen markers.
• Confirms immunity from vaccination or past infection
  Prevents unnecessary repeat vaccination.
• Detects silent or asymptomatic infection
  Especially important for Hepatitis B and C.
• Includes liver function assessment
  Shows whether the liver is being affected.
• Supports early diagnosis and monitoring
  Reduces risk of long-term liver complications.
• Simple blood test with no preparation required
  No fasting or lifestyle changes needed.
• Provides clear, clinically actionable results
  Useful for both reassurance and medical decision-making.

How the test is carried out

We offer two convenient UK-wide testing options:

Clinic-based blood testing

• Choose your nearest UK clinic
• A healthcare professional collects a blood sample
• The sample is analysed in a certified laboratory
• Results are issued once testing is complete

Home or hotel blood collection (+£60)

• A qualified phlebotomist visits your home, workplace, or hotel
• Blood is collected at a time convenient for you
• No clinic visit required
• Available nationwide across the UK

Both options use the same laboratory standards and clinical accuracy.

Understanding your Hepatitis A, B & C Profile results

Hepatitis A markers

• IgM positive → Recent or acute Hepatitis A infection
• IgG positive / IgM negative → Immunity from past infection or vaccination
• Both negative → No immunity, susceptible

Hepatitis B markers

• Surface Antigen positive → Active Hepatitis B infection
• Surface Antibodies positive → Immunity (vaccination or past infection)
• Core IgG/IgM positive → Past or current natural infection

Combined interpretation determines infection stage or immunity status.

Hepatitis C markers

• Antibodies positive → Past or current exposure
• Antigen positive → Active Hepatitis C infection
• Antigen negative → No active infection

Liver Function Tests (LFTs)

LFTs assess liver enzymes and proteins to determine whether hepatitis is affecting liver health. Abnormal results may indicate inflammation or liver stress and guide further assessment.