Understanding the Hepatitis A Immunity (IgG/IgM) blood test

The Hepatitis A Immunity (IgG/IgM) blood test measures two types of antibodies produced in response to Hepatitis A virus infection: IgG antibodies and IgM antibodies. Together, these markers provide a clear picture of both immune protection and recent exposure.

IgG antibodies indicate long-term immunity, either from past natural infection or successful vaccination.

IgM antibodies indicate a recent or acute Hepatitis A infection, usually appearing early in the course of illness.

By testing both antibodies together, this profile allows accurate differentiation between immunity, recent infection, and susceptibility, making it a comprehensive assessment of Hepatitis A status.

When a Hepatitis A Immunity (IgG/IgM) test is recommended

This test is recommended when there is a need to confirm immunity to Hepatitis A, investigate possible recent infection, or clarify Hepatitis A status following symptoms, exposure, or vaccination.

Hepatitis A is transmitted primarily through contaminated food or water. While it does not cause chronic infection, it can lead to significant short-term illness, making early identification and immunity confirmation important.

Testing may be appropriate if you:

• Want to confirm immunity after Hepatitis A vaccination
• Have symptoms suggestive of acute hepatitis
• Have unexplained abnormal liver function tests
• Have been exposed to someone with Hepatitis A
• Have recently travelled to higher-risk regions
• Work in food handling, healthcare, or childcare
• Need reassurance about protection against Hepatitis A
• Require occupational or public health screening

Benefits of the Hepatitis A Immunity (IgG/IgM) test

• Confirms protective immunity to Hepatitis A
  IgG antibodies indicate long-term protection.
• Identifies recent or acute infection
  IgM antibodies detect early infection.
• Clarifies infection timing
  Distinguishes immunity from active illness.
• Supports investigation of liver abnormalities
  Useful in unexplained hepatitis presentations.
• Essential for travel and occupational screening
  Confirms protection in higher-risk settings.
• Prevents unnecessary vaccination
  Identifies existing immunity.
• Simple blood test with no preparation required
  No fasting or lifestyle changes needed.
• Provides reassurance and clear clinical answers
  Reduces uncertainty for patients and clinicians.

How the test is carried out

We offer two convenient UK-wide testing options:

Clinic-based blood testing

• Choose your nearest UK clinic
• A healthcare professional collects a blood sample
• The sample is analysed in a certified laboratory
• Results are issued once testing is complete

Home or hotel blood collection (+£60)

• A qualified phlebotomist visits your home, workplace, or hotel
• Blood is collected at a time convenient for you
• No clinic visit required
• Available nationwide across the UK

Both options use the same laboratory standards and clinical accuracy.

Understanding your Hepatitis A Immunity (IgG/IgM) results

IgG and IgM both negative

This indicates no immunity and no recent infection. You are susceptible to Hepatitis A.

Typical UK interpretation:

• Not immune
• Vaccination may be recommended

IgG positive and IgM negative

This indicates protective immunity due to past infection or vaccination. There is no current infection.

Typical UK interpretation:

• Immune
• No further action required

IgG positive and IgM positive

This pattern indicates a recent or ongoing Hepatitis A infection, often during early recovery.

Typical UK interpretation:

• Recent or acute infection
• Clinical follow-up may be advised

IgG negative and IgM positive

This indicates a very recent acute Hepatitis A infection before long-term immunity has developed.

Typical UK interpretation:

• Acute infection
• Medical assessment recommended