1,25-dihydroxyvitamin D (calcitriol)
This test measures 1,25-dihydroxyvitamin D, the biologically active form of vitamin D. It is used to investigate calcium imbalance, kidney disease and...
Histamine (Blood)
148.00
The Histamine blood test measures circulating histamine levels. It helps investigate allergic reactions, histamine intolerance and mast cell activation.
Turnaround time
5 days
Biomarkers count
1
Same-Day Appointments
UKAS Accredited Labs
Book your test
Under 18? Patients under 18 can only be seen at GB Medlabs and Clinilabs, Monday to Friday only.
1
Email
2
Service
3
Details
4
Confirm
{{ emailError }}
Choose Service Type
Home visit
Professional phlebotomist comes to you
+ £{{ home_visit_fee }}
In clinic
Visit our clinic for your test
{{ clinic_visit_fee > 0 ? '+ £' + clinic_visit_fee : 'Free' }}
Home Visit Details
{{ homeAddressError }}
Home visits require at least 24 hours notice.
{{ homeTimeError }}
Choose Clinic Option
Select a clinic:
{{ clinic.name }}
{{ clinic.full_address }}
{{ selectedClinic.name }}
{{ selectedClinic.full_address }}
Select a date
{{ timeSlotAlert }}
Select an hour
Available time slots: {{ timeSlots.length}}
{{ slot.preview }}
{{ selectedTime.preview }}
Loading add-ons...
{{ addOnError }}
No recommended add-ons available.
×
{{ addon.name }}
£{{ addon.price }}
{{ addon.excerpt }}
Selected
Selected ({{ selectedAddOns.length }})
£{{ addOnsTotal }}
- {{ sa.name }} £{{ sa.price }}
Included in total above.
Details about Histamine (Blood)
What is the Histamine (Blood) test?
The Histamine (Blood) test measures the concentration of histamine present in the bloodstream. Histamine is a biologically active compound released mainly by mast cells and basophils as part of immune and inflammatory responses.
Histamine plays a central role in allergic reactions, gastric acid secretion, immune signalling and blood vessel regulation. When released in excess, it can cause a wide range of symptoms affecting the skin, gut, respiratory system and cardiovascular system.
This test is commonly used in the assessment of histamine intolerance, allergic conditions, and mast cell–related disorders.
Why do I need a Histamine blood test?
Abnormally high histamine levels can lead to persistent or unexplained symptoms that are often misattributed to other conditions. Measuring blood histamine helps determine whether histamine excess may be contributing to symptoms.
You may need a Histamine test if you experience:
- Flushing or redness of the skin
- Headaches or migraines
- Hives or itching
- Nasal congestion or sneezing
- Gastrointestinal symptoms (bloating, diarrhoea)
- Palpitations
- Dizziness or low blood pressure
- Symptoms triggered by certain foods
- Suspected mast cell activation
Conditions where histamine testing may be helpful include:
- Histamine intolerance
- Allergic reactions
- Mast cell activation disorders
- Unexplained chronic inflammatory symptoms
Benefits of the Histamine (Blood) test
- Assesses circulating histamine levels
Identifies histamine excess. - Supports allergy investigations
Useful alongside IgE testing. - Helps evaluate histamine intolerance
Supports dietary and lifestyle assessment. - Relevant for mast cell disorders
Aids investigation of mast cell activity. - Explains unexplained multisystem symptoms
Useful when symptoms are non-specific. - Clinically recognised biomarker
Used in specialist immunology settings. - Guides treatment strategies
Supports antihistamine or dietary approaches. - Simple blood test
Requires only a single blood sample.
Step by step – how the test works
You can access Histamine (Blood) testing UK-wide through two options:
- Clinic appointment
Attend your nearest UK clinic where a healthcare professional will take your blood sample. - At-home or hotel visit (£60 extra)
A qualified phlebotomist visits your home or hotel for sample collection.
Your sample is analysed in an accredited UK laboratory, and results are delivered securely.
Your results explained
Low histamine levels
Typically not clinically significant and usually do not cause symptoms.
Typical UK reference range:
- < 0.5 ng/mL (laboratory dependent)
Normal histamine levels
Suggest balanced histamine release and metabolism.
Typical UK interpretation:
- Within laboratory reference range
High histamine levels
May indicate excessive histamine release or reduced breakdown, commonly seen in allergy, histamine intolerance or mast cell activation.
Typical UK interpretation:
- Above laboratory reference range
Results should always be interpreted in clinical context.
How It Works
Simple steps to get your results
1
Book Online
Choose your test online and book in seconds. Select your preferred clinic location or home visit option.
2
Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
3
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
Take control of your health with London Blood Tests
WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.
Frequently Asked Questions
It measures histamine circulating in the bloodstream.
It supports investigation of histamine intolerance but is not a standalone diagnosis.
Yes. Antihistamines may reduce detectable histamine levels.
Fasting is often recommended; follow booking instructions.
Yes. Levels can vary depending on triggers and timing.
Yes. It is often used alongside other mast cell markers.
Yes. Stress may influence histamine release.
Yes, when clinically indicated.
Yes. Home or hotel phlebotomy is available UK-wide for £60 extra.
Yes. Interpretation should consider symptoms and medications.
Similar Products in Blood Testing
Discover more options in this category:
17-Hydroxyprogesterone
This test measures 17-hydroxyprogesterone, a hormone involved in cortisol production. It is used to assess adrenal function and diagnose congenital ad...
5 HIAA
The 5-HIAA (5-Hydroxyindoleacetic Acid) blood test measures the amount of 5-HIAA, a breakdown product of serotonin, in the bloodstream. Elevated level...
6-Thioguanine Nucleotides
This test measures 6-thioguanine nucleotide levels to monitor thiopurine medications. It helps optimise treatment effectiveness while reducing toxicit...
7 Sexually Transmitted Infections by PCR
This PCR screen detects seven common sexually transmitted infections with high accuracy. It identifies active infections even when symptoms are mild o...