Immunoglobulin G
Private Immunoglobulin G blood test in London for £48, measuring one total IgG marker with results expected in around 1 business day.
Turnaround time
1 business day
Biomarkers count
1
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Overview of the Immunoglobulin G Test
The Immunoglobulin G blood test measures the total concentration of IgG antibodies circulating in serum.
The test contains 1 biomarker: Immunoglobulin G.
IgG is the most abundant immunoglobulin class in human blood and plays a major role in long-term antibody-mediated protection against bacteria, viruses and other pathogens.
It is produced by plasma cells following immune activation and forms an important part of immunological memory.
Total IgG testing is commonly used when investigating recurrent infections, suspected antibody deficiency or unexplained abnormalities in blood proteins.
Low IgG can occur in primary immunodeficiency conditions as well as secondary causes such as selected medications, haematological disorders, protein loss or other medical conditions.
Elevated IgG can occur with chronic infection, autoimmune disease, liver disease and both polyclonal and monoclonal immunoglobulin disorders.
Total IgG does not show whether a person has protective antibodies against a specific infection.
For that purpose, a pathogen- or vaccine-specific IgG test is required.
Likewise, a normal total IgG result does not guarantee that every aspect of antibody function is normal.
Some people can have normal total IgG but reduced individual IgG subclasses or inadequate functional antibody responses to vaccination.
The result should therefore be interpreted with infection history, IgA, IgM and more specialised immunology investigations where appropriate.
What Does the Immunoglobulin G Test Check?
The test quantifies total circulating IgG, the principal immunoglobulin responsible for sustained systemic antibody-mediated immunity. This test measures 1 biomarker.
Immunoglobulin G
Measures total serum IgG to provide information about systemic antibody production and humoral immune function.
Who May Benefit From the Immunoglobulin G Test?
Total IgG may be useful when recurrent infections, suspected antibody deficiency or abnormal protein measurements require further assessment.
People with recurrent chest or sinus infections - Low IgG can contribute to impaired defence against respiratory pathogens.
People with frequent bacterial infections - Quantitative antibody testing may form part of an immune-deficiency investigation.
People with a previous low IgG result - Repeat measurement can determine whether the reduction persists.
People undergoing specialist immunology assessment - Total IgG is a fundamental baseline immune marker.
People taking treatments that can suppress antibody production - Monitoring may be appropriate depending on the medicine.
People with unexplained high Globulin or Total Protein - Increased IgG production can contribute to these findings.
People with autoimmune or chronic inflammatory disease - Polyclonal IgG elevation can accompany sustained immune activation.
People being investigated for an immunoglobulin or plasma-cell disorder - Total IgG may contribute to the wider protein assessment.
How to Prepare
The timing of testing relative to an immunoglobulin-replacement infusion can materially affect the result.
Follow specialist timing instructions when IgG is being used to monitor replacement therapy.
Symptoms and Reasons to Consider the Immunoglobulin G Test
IgG abnormalities do not produce one specific symptom pattern. Low concentrations are most often considered when infections are unusually frequent, severe or persistent.
Repeated sinus infections - Impaired antibody production can increase susceptibility to respiratory bacterial infection.
Recurrent bronchitis or pneumonia - Significant IgG deficiency can contribute.
Frequent infections requiring antibiotics - Broader immune assessment may be appropriate.
Poor recovery from infections - Inadequate humoral immune function is one possible contributor.
A previous abnormal IgG result - Repeat testing can determine whether the abnormality persists.
Unexplained raised blood proteins - Elevated immunoglobulin production may contribute to high Globulin or Total Protein.
Normal total IgG does not rule out an IgG subclass deficiency or impaired specific antibody response.
People with clinically significant recurrent infections may therefore require additional immunology assessment even when total IgG falls within the laboratory reference interval.
How to Book Your Immunoglobulin G Test
The Immunoglobulin G test can be booked privately as an individual quantitative immune marker.
Choose the Immunoglobulin G
Select the individual total IgG blood test online.
Select your sample collection option
Choose an in-clinic appointment or professional home or hotel phlebotomy.
Attend your appointment
A trained healthcare professional collects the required venous blood specimen.
Laboratory analysis
Your serum is analysed to determine the total Immunoglobulin G concentration.
Receive your results securely
Your authorised IgG result is delivered securely for interpretation alongside other immune findings.
When Will I Receive My Results?
The expected turnaround for Immunoglobulin G is approximately 1 business day after laboratory receipt.
Total IgG is a routinely performed quantitative immunoglobulin assay.
The laboratory analyses the sample and completes the required quality-control and authorisation procedures before release.
Turnaround begins from laboratory receipt rather than necessarily from the exact time at which your blood is collected.
More specialist tests such as IgG Subclasses or vaccine-antibody responses may take longer if subsequently requested.
Understanding Your Results
A low total IgG result can indicate reduced systemic antibody production.
Interpretation depends on the severity, whether IgA or IgM are also reduced and whether the person has a clinically important history of recurrent infection.
A high IgG concentration can occur with chronic immune activation, autoimmune disease, infection or liver disease.
A markedly abnormal result may require additional testing to establish whether the increase is polyclonal or monoclonal.
Normal total IgG does not guarantee normal functional antibody immunity.
An individual may have normal total IgG but abnormalities affecting IgG Subclasses or specific vaccine responses.
For this reason, results should be interpreted in the wider immunological context.
Why Book With London Blood Tests?
London Blood Tests provides targeted quantitative IgG measurement with private professional blood collection.
Measures total IgG directly - Assesses the principal circulating immunoglobulin class.
Relevant to recurrent infection assessment - Low IgG can contribute to increased infection susceptibility.
Useful in suspected antibody deficiency - Provides an important first-line immune marker.
Can guide specialist testing - Abnormal results may lead to IgG Subclasses or functional antibody studies.
Useful in abnormal blood-protein investigations - IgG can contribute to raised Globulin or Total Protein.
Fast results - Expected in approximately 1 business day.
Private collection options - Clinic and home or hotel phlebotomy can be arranged.
Clear pricing - The Immunoglobulin G test costs £48.
Private Immunoglobulin G Blood Test in London
London Blood Tests provides private Immunoglobulin G testing in London for people requiring quantitative assessment of total IgG.
The test costs £48 and measures 1 biomarker: Immunoglobulin G.
Results are expected approximately 1 business day after laboratory receipt.
The result should be interpreted alongside infection history and other immunoglobulin measurements where appropriate.