What is the LDL7 Subfractions test?

The LDL7 Subfractions test is an advanced lipid analysis that separates low-density lipoprotein (LDL) cholesterol into seven distinct particle subfractions based on size and density.

Not all LDL particles carry the same cardiovascular risk. Smaller, denser LDL particles are more atherogenic, meaning they penetrate arterial walls more easily and are more prone to oxidation, while larger, buoyant LDL particles are generally considered less harmful.

This test provides a more refined cardiovascular risk assessment than standard LDL-C measurements alone.

Why do I need an LDL7 Subfractions test?

Standard cholesterol tests may underestimate cardiovascular risk in some individuals. LDL subfraction testing helps uncover hidden risk, especially when LDL-C appears “normal”.

You may need an LDL7 Subfractions test if you:

• Have normal LDL but strong family history of heart disease
• Have metabolic syndrome or insulin resistance
• Have diabetes or prediabetes
• Have unexplained cardiovascular risk
• Have high triglycerides
• Are optimising cardiovascular prevention
• Want advanced lipid risk assessment

Conditions associated with small, dense LDL particles include:

• Insulin resistance
• Type 2 diabetes
• Obesity
• Metabolic syndrome
• Cardiovascular disease

Benefits of the LDL7 Subfractions test

• Advanced cardiovascular risk stratification
  Goes beyond standard LDL-C testing.
• Identifies atherogenic LDL particles
  Detects small, dense LDL fractions.
• Improves preventive decision-making
  Supports targeted lifestyle or treatment plans.
• Useful in metabolic health assessment
  Links lipid patterns to insulin resistance.
• Explains risk with normal cholesterol
  Reveals hidden atherosclerotic risk.
• Clinically relevant in high-risk patients
  Used in advanced lipidology.
• Supports personalised medicine
  Tailors cardiovascular strategies.
• Single blood test
  Detailed insights from one sample.

Step by step – how the test works

You can access LDL7 Subfractions testing UK-wide through two options:

1. Clinic appointment
   Attend your nearest UK clinic where a healthcare professional will take your blood sample.
2. At-home or hotel visit (£60 extra)
   A qualified phlebotomist comes to your home or hotel, so you don’t need to travel.

Your sample is analysed in an accredited UK laboratory using advanced lipid fractionation techniques.

Your results explained

Low cardiovascular risk pattern

• Predominantly large, buoyant LDL particles
• Minimal small, dense LDL fractions

Typical UK interpretation:

• LDL Pattern A (larger LDL)

Intermediate risk pattern

• Mixed LDL particle sizes

Typical UK interpretation:

• Mixed LDL subfractions

High cardiovascular risk pattern

• High proportion of small, dense LDL particles

Typical UK interpretation:

• LDL Pattern B (small, dense LDL)

Results should be interpreted alongside ApoB, triglycerides and clinical risk factors.