Lupus Anticoagulant and Anticardiolipin Antibodies (Hughes Syndrome)
Private Hughes Syndrome blood test in London for £365.99, assessing lupus anticoagulant and anticardiolipin antibodies with results in around 4 days.
Turnaround time
4 business days
Biomarkers count
1
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Overview of the Lupus Anticoagulant and Anticardiolipin Antibodies (Hughes Syndrome)
The Lupus Anticoagulant and Anticardiolipin Antibodies test is a combined specialist investigation used during assessment of antiphospholipid syndrome, also known as Hughes syndrome.
The test contains 1 combined laboratory biomarker: Lupus Anticoagulant and Anticardiolipin Abs (Hughes Syndrome).
Antiphospholipid syndrome is an autoimmune condition in which persistent antiphospholipid antibodies are associated with an increased risk of abnormal blood clots and defined pregnancy complications.
This profile evaluates two important parts of the antiphospholipid antibody assessment.
Lupus Anticoagulant is detected through specialist phospholipid-dependent coagulation assays.
Anticardiolipin Antibodies are antibodies directed against phospholipid-associated protein complexes and are commonly assessed as IgG and IgM classes according to laboratory methodology.
Despite the laboratory term "anticoagulant", Lupus Anticoagulant is associated clinically with thrombosis rather than protection from clotting.
Antiphospholipid antibodies can occur transiently during infection or inflammation.
For this reason, one positive laboratory result is usually insufficient to establish persistent APS-related antibody positivity.
Repeat testing at least 12 weeks later is commonly required when an initial result is positive and APS remains clinically relevant.
Diagnosis or classification of antiphospholipid syndrome also requires an appropriate clinical history, such as documented thrombosis or specified pregnancy morbidity.
A positive antibody test in a person who has never experienced a clot or relevant pregnancy complication does not automatically mean that treatment with anticoagulants is required.
Anticoagulant medication can interfere particularly with Lupus Anticoagulant testing, making accurate medication history essential.
The combined test therefore requires careful interpretation by an appropriately qualified clinician.
What Does the Lupus Anticoagulant and Anticardiolipin Antibodies (Hughes Syndrome) Test Check?
This test measures 1 combined laboratory biomarker.
Lupus Anticoagulant and Anticardiolipin Abs (Hughes Syndrome)
Assesses Lupus Anticoagulant activity and Anticardiolipin antibodies to support investigation of antiphospholipid syndrome, thrombosis and selected pregnancy complications.
Who May Benefit From the Lupus Anticoagulant and Anticardiolipin Antibodies (Hughes Syndrome) Test?
This combined profile may be appropriate when antiphospholipid syndrome is specifically being investigated.
People with unexplained deep vein thrombosis - APS can contribute to acquired venous thrombosis.
People with an unexplained pulmonary embolism - Persistent antiphospholipid antibodies may form part of the thrombophilia assessment.
Younger people with arterial thrombosis or stroke - APS can cause arterial as well as venous thrombotic events.
People with recurrent pregnancy loss - Antiphospholipid syndrome is one important autoimmune cause considered during selected recurrent miscarriage assessments.
People with defined placental pregnancy complications - APS can affect placental circulation and contribute to selected obstetric complications.
People with systemic lupus erythematosus - Antiphospholipid antibodies occur more commonly in people with certain systemic autoimmune conditions.
People with previously positive Cardiolipin Antibodies - Combined testing can provide a broader antiphospholipid assessment.
People with a previous positive Lupus Anticoagulant result - Additional antibody testing can provide further context.
People undergoing repeat testing to confirm persistent positivity - Repeat analysis after at least 12 weeks may be clinically important.
People referred by a haematologist, rheumatologist or obstetric specialist for Hughes syndrome assessment - The combined profile can provide relevant laboratory evidence.
How to Prepare
Do not stop anticoagulant medication independently.
The current laboratory handling requirements mean the citrate specimen should reach the laboratory promptly; if delay is expected, specialist double-spin, separation, freezing and frozen transport may be required.
Symptoms and Reasons to Consider the Lupus Anticoagulant and Anticardiolipin Antibodies (Hughes Syndrome) Test
Antiphospholipid antibodies themselves do not usually produce symptoms until a thrombotic or pregnancy-related event occurs.
Pain and swelling affecting one leg - These can be symptoms of deep vein thrombosis.
Sudden unexplained breathlessness - Pulmonary embolism can present with acute shortness of breath and requires emergency assessment.
Chest pain with breathing - Pleuritic chest pain can occur with pulmonary embolism.
An unexplained blood clot without a major temporary trigger - Persistent antiphospholipid antibodies may be considered as one potential risk factor.
Stroke or transient neurological symptoms at a younger age - Arterial APS can affect cerebral circulation.
Repeated miscarriages - Persistent antiphospholipid antibodies may be relevant in selected recurrent pregnancy loss.
Previous severe pregnancy complications related to placental dysfunction - Specialist obstetric APS assessment may be appropriate.
A prolonged APTT without a history of unusual bleeding - Lupus Anticoagulant can prolong some laboratory coagulation tests.
A previous positive Cardiolipin or Lupus Anticoagulant result - Repeat or combined testing may help establish persistence and the antibody pattern.
These symptoms and complications have many potential causes, and an antibody result alone cannot determine why a clot or pregnancy complication occurred.
Acute chest pain, sudden breathlessness, coughing blood, unilateral leg swelling or new neurological symptoms require emergency medical assessment.
How to Book Your Lupus Anticoagulant and Anticardiolipin Antibodies (Hughes Syndrome) Test
This combined APS test requires carefully handled blood samples.
Choose the Lupus Anticoagulant and Anticardiolipin Antibodies (Hughes Syndrome)
Select the combined antiphospholipid antibody test.
Select your sample collection option
Choose a clinic or professional collection pathway capable of meeting the specialist citrate processing requirements.
Attend your appointment
The required serum and citrate specimens are collected and your anticoagulant and clinical history should be documented.
Laboratory analysis
Specialist coagulation and immunology methods are used to assess Lupus Anticoagulant and Anticardiolipin Antibodies.
Receive your results securely
Your authorised combined APS laboratory report is delivered securely.
When Will I Receive My Results?
The current London Blood Tests turnaround for the Lupus Anticoagulant and Anticardiolipin Antibodies (Hughes Syndrome) test is approximately 4 days after the required specimens reach the laboratory.
The profile involves both specialist coagulation testing and antibody analysis, so multiple laboratory processes must be completed before the combined report can be authorised.
Specimen handling can affect the timeline. Citrate plasma used for Lupus Anticoagulant assessment is particularly sensitive to collection and transport conditions.
An unsuitable citrate specimen may need to be recollected.
If an initial result is positive, repeat testing after at least 12 weeks may subsequently be advised to establish whether the antiphospholipid antibody finding is persistent. That repeat assessment is separate from the initial 4-day laboratory turnaround.
Understanding Your Results
A negative combined result means significant Lupus Anticoagulant activity and Anticardiolipin antibody positivity were not demonstrated by the methods used.
This reduces the likelihood of these antiphospholipid antibody patterns but does not exclude every laboratory marker associated with APS.
A positive Lupus Anticoagulant result indicates a phospholipid-dependent coagulation pattern associated with increased thrombosis risk.
A positive Anticardiolipin antibody result indicates measurable antibodies against cardiolipin-associated complexes.
The clinical significance of Anticardiolipin antibodies depends partly on the antibody class and level.
Low-level or transient antibodies can occur without antiphospholipid syndrome.
Persistent and clinically significant positivity is more important.
A diagnosis of APS is not made from one blood test alone.
The antibody findings must be interpreted alongside documented thrombosis or recognised pregnancy morbidity, and persistence generally needs to be established on repeat testing.
Anticoagulant medication and recent illness can also affect interpretation.
Why Book With London Blood Tests?
Private Hughes syndrome testing in London - Access combined antiphospholipid antibody assessment privately.
Two important APS markers assessed together - The profile evaluates both Lupus Anticoagulant and Anticardiolipin antibodies.
Relevant to unexplained thrombosis - Results can contribute to assessment of venous and arterial clotting events.
Relevant to recurrent pregnancy loss - Antiphospholipid antibodies are an important consideration in selected obstetric histories.
Specialist coagulation and immunology analysis - Both functional clotting and antibody methodologies are involved.
Correct citrate processing - Appropriate collection routes can be selected for the specialist sample requirements.
Secure reporting - Receive your authorised report securely.
Clear pricing - The Hughes Syndrome profile costs £365.99.
Private Lupus Anticoagulant and Anticardiolipin Antibodies (Hughes Syndrome) Blood Test in London
London Blood Tests provides private Lupus Anticoagulant and Anticardiolipin Antibody testing in London for people requiring specialist investigation of antiphospholipid syndrome.
The test costs £365.99 and contains one combined laboratory profile.
Results are expected approximately 4 days after laboratory receipt.
Persistent antibody positivity and an appropriate clinical history are required before the findings can be interpreted as antiphospholipid syndrome.