Recurrent Miscarriage Profile (Female)

What is the Recurrent Miscarriage Profile (Female)?

The Recurrent Miscarriage Profile (Female) is an advanced blood and genetic testing panel designed to investigate underlying medical causes of repeated pregnancy loss. Recurrent miscarriage is often multifactorial, involving clotting disorders, immune abnormalities, or genetic factors.

This profile includes:

• Full Blood Count (FBC)

• Prothrombin Time (PT)

• Activated Partial Thromboplastin Time (APTT)

• Fibrinogen

• Antithrombin III

• Factor V Leiden – common mutation

• Factor II Prothrombin – common mutation

• MTHFR Common Variants

• Lupus Anticoagulant

• Anticardiolipin Antibodies

• Protein C

• Free Protein S Antigen

• Chromosome Analysis

Together, these tests assess blood clotting balance, inherited thrombophilia, autoimmune clotting risk, and chromosomal abnormalities that may interfere with successful pregnancy.

Why do I need a Recurrent Miscarriage Profile?

Recurrent miscarriage is often defined as two or more consecutive pregnancy losses. In many cases, an underlying cause is present but not immediately obvious without targeted investigation.

This profile helps identify conditions that increase the risk of placental clotting, impaired implantation, or early pregnancy disruption. Identifying a cause allows for personalised management and improved future pregnancy outcomes.

You may benefit from this test if you:

• Have experienced two or more miscarriages

• Have a history of pregnancy loss at early or later stages

• Have personal or family history of blood clots

• Have autoimmune disease or unexplained inflammation

• Have had pregnancy complications such as pre-eclampsia

• Have known clotting or genetic risk factors

• Are planning future pregnancy after loss

• Have unexplained infertility with pregnancy loss

Benefits of the Recurrent Miscarriage Profile

1. Identifies inherited clotting disorders
   Detects Factor V Leiden and Prothrombin gene mutations.

2. Assesses autoimmune clotting risk
   Lupus anticoagulant and anticardiolipin antibodies assess antiphospholipid syndrome.

3. Evaluates natural anticoagulant levels
   Protein C, Protein S, and antithrombin help regulate clot formation.

4. Screens for chromosomal abnormalities
   Chromosome analysis identifies genetic causes of miscarriage.

5. Assesses overall blood health
   FBC identifies anaemia or platelet abnormalities.

6. Evaluates coagulation balance
   PT, APTT, and fibrinogen assess clotting efficiency.

7. Supports personalised pregnancy planning
   Results guide targeted preventive strategies.

8. Provides clarity after unexplained losses
   Helps reduce uncertainty and supports informed next steps.

Step-by-step – how we offer Recurrent Miscarriage Profile testing

Clinic-based testing (UK-wide)

• Choose your nearest UK clinic

• Attend your appointment

• Blood samples collected by a qualified clinician or phlebotomist

• Samples are sent to the laboratory for analysis

At-home or hotel testing (+£60)

• A qualified phlebotomist visits your home or hotel

• Blood samples collected in a comfortable, familiar setting

• No clinic visit or travel required

Both services are available UK-wide.

Your Recurrent Miscarriage Profile results explained

Results within normal range

Normal results suggest no detectable clotting, immune, or chromosomal abnormalities. While reassuring, miscarriage can still occur due to other factors not assessed in this profile.

These results help exclude major medical causes.

UK reference interpretation:

• Normal: Within laboratory reference ranges

Abnormal clotting or immune markers

Abnormal results may indicate inherited thrombophilia, antiphospholipid syndrome, or reduced natural anticoagulant activity. These conditions can impair placental blood flow and increase miscarriage risk.

Management strategies may be available following specialist review.

UK reference interpretation:

• Abnormal: Outside reference ranges or mutations detected

Chromosomal abnormalities detected

Chromosome analysis may identify balanced or unbalanced rearrangements that affect embryo viability. This information is important for genetic counselling and future pregnancy planning.

UK reference interpretation:

• Abnormal karyotype: Chromosomal variation detected