Metanepherine (Plasma)
The Plasma Metanephrines test measures adrenal hormone metabolites linked to excess adrenaline production. It is used to investigate suspected adrenal tumours and unexplained high blood pressure.
Turnaround time
Results available 10 days after receipt in laboratory.
Biomarkers count
1
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Details about Metanepherine (Plasma)
What is the Plasma Metanephrines test?
The Plasma Metanephrines test measures metanephrine and normetanephrine, which are breakdown products of adrenaline (epinephrine) and noradrenaline (norepinephrine). These hormones are produced by the adrenal glands and play a key role in stress response and blood pressure regulation.
Unlike direct adrenaline measurements, metanephrines are more stable in the blood, making this test highly sensitive for detecting adrenal hormone overproduction. It is considered one of the most reliable screening tests for pheochromocytoma and related adrenal disorders.
Why do I need a Plasma Metanephrines test?
Excess adrenal hormone release can cause sudden or persistent symptoms and may be difficult to diagnose without targeted testing.
You may need this test if you experience:
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Persistent or episodic high blood pressure
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Severe headaches
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Palpitations or rapid heartbeat
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Excessive sweating
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Anxiety or panic-like symptoms
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Tremors
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Flushing
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Adrenal mass seen on imaging
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Unexplained cardiovascular symptoms
The test helps determine whether symptoms are driven by abnormal adrenal hormone activity.
Benefits of the test
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Highly sensitive adrenal screening test
Detects subtle hormone excess. -
Gold-standard test for pheochromocytoma screening
Recommended in adrenal assessment pathways. -
More reliable than adrenaline testing
Metanephrines are more stable markers. -
Explains unexplained hypertension
Especially when blood pressure is difficult to control. -
Supports investigation of adrenal tumours
Helps guide further imaging and evaluation. -
Simple blood-based testing
Requires only one blood sample. -
Widely used in endocrine practice
Standard test for adrenal hormone disorders. -
Reduces diagnostic uncertainty
Helps rule in or out serious adrenal conditions.
Step-by-step: How we offer testing
Clinic-based testing (UK-wide)
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Choose your nearest UK clinic
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Attend your appointment
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Blood sample taken after a period of rest
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Sample sent to the laboratory
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Results are issued once analysis is complete
Home or hotel visit (+£60, UK-wide)
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Mobile phlebotomist attends your location
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Blood sample taken with resting conditions
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Sample securely transported to the laboratory
Pre-test conditions (resting, posture, and medication review) may be advised for accurate results.
Your results explained
Low / normal levels
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Metanephrines within reference range
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UK standard (typical):
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Metanephrine: <0.50 nmol/L
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Normetanephrine: <0.90 nmol/L
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Suggests no evidence of adrenal hormone excess
Mildly elevated levels
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Slightly raised metanephrines
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May be influenced by stress, posture, or medications
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Often requires repeat testing or further evaluation
High levels
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Significantly elevated metanephrines
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Well above reference range
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Strongly suggestive of pheochromocytoma or adrenal hormone overproduction
Results should always be interpreted alongside clinical symptoms and imaging where appropriate.
How It Works
Simple steps to get your results
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Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
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WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.