Mitochondrial Antibodies
The Mitochondrial Antibodies test detects autoantibodies linked to autoimmune liver disease. It is most commonly used in the investigation of primary biliary cholangitis.
Turnaround time
3 days
Biomarkers count
1
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Details about Mitochondrial Antibodies
What is the Mitochondrial Antibodies test?
The Mitochondrial Antibodies (AMA) test measures autoantibodies directed against components of mitochondria, the energy-producing structures within cells. These antibodies are most strongly associated with primary biliary cholangitis (PBC), an autoimmune condition affecting the bile ducts of the liver.
AMA are not markers of mitochondrial dysfunction itself; instead, they reflect an immune-mediated attack on liver tissue. The test is highly specific for PBC and is a key part of autoimmune liver disease assessment, often requested alongside liver function tests.
Why do I need a Mitochondrial Antibodies test?
Autoimmune liver disease can develop gradually and may be present even when symptoms are mild or non-specific. Testing helps identify immune-related causes of abnormal liver findings.
You may need this test if you:
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Have persistently abnormal liver enzymes
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Experience unexplained fatigue
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Have itching (pruritus) without a clear cause
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Have jaundice or pale stools
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Have a family history of autoimmune liver disease
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Are being investigated for cholestatic liver disease
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Have other autoimmune conditions
The test helps determine whether liver abnormalities are autoimmune in origin.
Benefits of the test
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Highly specific for autoimmune liver disease
Strongly associated with primary biliary cholangitis. -
Supports early diagnosis
Can detect disease before advanced liver damage. -
Guides further liver investigation
Helps direct imaging and specialist referral. -
Clarifies cause of abnormal liver tests
Distinguishes autoimmune from metabolic causes. -
Simple blood-based testing
Requires only one blood sample. -
Widely used in hepatology
Standard autoimmune liver marker. -
Supports long-term monitoring
Useful in ongoing disease assessment. -
Improves diagnostic confidence
Reduces uncertainty in liver disease work-up.
Step-by-step: How we offer testing
Clinic-based testing (UK-wide)
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Choose your nearest UK clinic
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Attend your appointment
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Blood sample taken by a clinician
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Sample sent to the laboratory
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Results issued once analysis is complete
Home or hotel visit (+£60, UK-wide)
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Mobile phlebotomist attends your location
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Blood sample taken at home or hotel
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Sample securely transported to the laboratory
Your results explained
Negative AMA
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No mitochondrial antibodies detected
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UK standard: Negative
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Makes primary biliary cholangitis unlikely
Positive AMA
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Mitochondrial antibodies detected
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UK standard: Positive
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Strongly suggests autoimmune liver disease, particularly PBC
Results should be interpreted alongside liver function tests, imaging, and clinical findings.
How It Works
Simple steps to get your results
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Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
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WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.