The MTHFR Common Variants test identifies genetic changes that affect folate metabolism and methylation pathways. It helps explain elevated homocysteine, nutrient deficiencies, and related health risks.
Turnaround time
3 weeks
Biomarkers count
1
Professional phlebotomist comes to you
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The MTHFR Common Variants test is a genetic blood test that analyses common variations in the MTHFR (methylenetetrahydrofolate reductase) gene. This gene plays a critical role in converting folate into its active form, which is essential for DNA synthesis, detoxification, neurotransmitter production, and cardiovascular health.
The most commonly tested variants are C677T and A1298C. Certain variants can reduce enzyme efficiency, leading to impaired methylation, altered folate metabolism, and elevated homocysteine levels.
This test identifies inherited genetic variants—it does not change over time and only needs to be done once.
MTHFR variants may contribute to health issues by affecting folate utilisation and methylation capacity, even when dietary intake appears adequate.
You may benefit from this test if you:
Have elevated homocysteine levels
Have unexplained cardiovascular risk
Experience fatigue or brain fog
Have recurrent pregnancy loss or fertility concerns
Have poor response to standard folic acid supplements
Have neurological or mood-related symptoms
Have a family history of thrombosis
Want insight into personalised nutrition or supplementation
Testing helps identify whether genetic factors may be influencing metabolic or cardiovascular risk.
Identifies common MTHFR gene variants
Detects C677T and A1298C variants.
Explains elevated homocysteine
Links genetics to cardiovascular risk.
Supports personalised nutrition strategies
Guides folate and B-vitamin optimisation.
Provides lifelong genetic insight
Results remain valid indefinitely.
Useful in fertility and pregnancy assessment
Methylation plays a key role in fetal development.
Supports neurological and cognitive health evaluation
Methylation affects neurotransmitter pathways.
Simple blood-based genetic testing
Requires only one sample.
Complements homocysteine and B-vitamin testing
Adds genetic context to biochemical results.
Clinic-based testing (UK-wide)
Choose your nearest UK clinic
Attend your appointment
Blood sample taken by a clinician
Sample sent for genetic analysis
Results issued once testing is complete
Home or hotel visit (+£60, UK-wide)
Mobile phlebotomist attends your location
Blood sample taken at home or hotel
Sample securely transported to the laboratory
Normal MTHFR gene function
Standard folate metabolism expected
Homocysteine regulation likely unaffected by MTHFR
One copy of C677T or A1298C
Mild reduction in enzyme activity
May contribute to elevated homocysteine under stress or low nutrient intake
Two copies of a variant or one of each
Greater reduction in enzyme efficiency
Higher likelihood of elevated homocysteine and methylation imbalance
Results should be interpreted alongside homocysteine, folate, vitamin B12, and clinical context.
Simple steps to get your results
Choose your test online and book in seconds. Select your preferred clinic location or home visit option.
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
Take control of your health with London Blood Tests
WhatsApp UsFollow these guidelines for accurate results
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.
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