What is the Mycoplasma genitalium PCR test?

The Mycoplasma genitalium PCR test detects the DNA of Mycoplasma genitalium, a sexually transmitted bacterium that can infect the urethra, cervix, rectum, and throat. It is increasingly recognised as a cause of persistent or recurrent genital symptoms.

Because Mycoplasma genitalium grows very slowly and poorly in culture, PCR testing is the preferred and most accurate diagnostic method. The test can be performed using urine samples or site-specific swabs, depending on clinical indication.

Why do I need a Mycoplasma genitalium PCR test?

Mycoplasma genitalium often causes mild or no symptoms and is frequently missed on routine STI screening. When untreated, it can lead to ongoing symptoms and complications.

You may need this test if you:

• Have persistent urethral or genital symptoms

• Experience burning on urination

• Have unusual discharge

• Have pelvic or testicular discomfort

• Have symptoms that persist despite negative chlamydia and gonorrhoea tests

• Have a partner diagnosed with Mycoplasma genitalium

• Want comprehensive STI screening

Testing helps identify a treatable cause of ongoing or unexplained symptoms.

Benefits of the test

1. Highly sensitive PCR detection
   Accurately identifies low-level infection.

2. Detects a commonly missed STI
   Not included in many standard panels.

3. Suitable for symptomatic and asymptomatic testing
   Identifies silent infections.

4. Useful in persistent or recurrent symptoms
   Helps explain ongoing issues.

5. Non-invasive sample options
   Often performed using urine.

6. Widely recommended in sexual health
   Recognised emerging STI.

7. Supports appropriate treatment selection
   Prevents unnecessary antibiotics.

8. Reduces onward transmission
   Early detection protects partners.

Step-by-step: How we offer testing

Clinic-based testing (UK-wide)

• Choose your nearest UK clinic

• Provide a urine sample or swab (site-specific if required)

• Sample sent to the laboratory for PCR analysis

• Results issued once testing is complete

Home or hotel testing (+£60, UK-wide)

• Urine or swab collection kit provided

• Sample collected at home or hotel

• Sample returned for laboratory testing

Your results explained

Negative result

• Mycoplasma genitalium DNA not detected

• No evidence of infection at the tested site

Positive result

• Mycoplasma genitalium DNA detected

• Confirms active infection

Treatment should be guided by current clinical guidelines and, where relevant, resistance considerations.