Streptococcus Pneumoniae IgG 23 Serotypes
This blood test measures IgG antibodies against 23 Streptococcus pneumoniae serotypes. It helps assess immune protection and response to pneumococcal vaccination.
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Details about Streptococcus Pneumoniae IgG 23 Serotypes
What is the Streptococcus Pneumoniae IgG 23 Serotypes Test?
The Streptococcus Pneumoniae IgG 23 Serotypes test measures IgG antibody levels against 23 different pneumococcal serotypes most commonly associated with invasive disease. These antibodies play a key role in protecting against bacterial infections affecting the lungs, bloodstream, and central nervous system.
The test is often used to evaluate immune competence, particularly the body’s ability to produce protective antibodies following natural exposure or vaccination (such as the 23-valent pneumococcal polysaccharide vaccine). It provides a detailed serotype-by-serotype assessment rather than a single total antibody value.
This test is widely used in immunology to investigate recurrent infections, suspected antibody deficiency, or inadequate vaccine response.
Why do I need a Streptococcus Pneumoniae IgG test?
Streptococcus pneumoniae is a leading cause of pneumonia, sinusitis, otitis media, sepsis, and meningitis. Some individuals are more susceptible to these infections due to impaired antibody production, even if routine blood tests appear normal.
You may benefit from this test if you experience:
- Recurrent chest infections or pneumonia
- Frequent sinus or ear infections
- Poor response to previous vaccinations
- Suspected immune deficiency
- Chronic lung disease with repeated infections
- Infections requiring frequent antibiotics
- Post-splenectomy or functional asplenia
- Monitoring immune response after pneumococcal vaccination
This test helps determine whether your immune system can mount an adequate antibody response and whether further immunological assessment may be required.
Benefits of the test
- Comprehensive immune assessment
Measures antibodies to 23 clinically relevant pneumococcal serotypes. - Evaluates vaccine response
Assesses whether pneumococcal vaccination has generated protective immunity. - Identifies functional antibody deficiency
Detects impaired immune responses even when total IgG is normal. - Supports investigation of recurrent infections
Particularly useful for repeated respiratory or ENT infections. - Guides further immunology testing
Helps determine if advanced immune investigations are needed. - Useful in adults and children
Applicable across age groups with recurrent infections. - Objective, measurable results
Provides numeric antibody levels per serotype. - Improves long-term infection risk assessment
Helps stratify susceptibility to pneumococcal disease.
Step-by-step: How we offer testing
Clinic-based testing (UK-wide)
- Choose your nearest UK clinic
- Attend your appointment
- A clinician draws a blood sample
- Sample is sent to the laboratory
- Results are issued once analysis is complete
Home or hotel visit (+£60, UK-wide)
- Book a mobile phlebotomist
- Blood sample taken at your home or hotel
- No need to travel to a clinic
- Sample securely transported to the laboratory
Your results explained
Low antibody levels (insufficient protection)
- Antibody levels below protective thresholds in multiple serotypes
- UK standard: Protective level generally ≥1.3 µg/mL per serotype
- Suggests reduced immune response or impaired vaccine response
Normal antibody levels (adequate protection)
- Protective antibody levels present across most serotypes
- UK standard: ≥1.3 µg/mL in the majority of tested serotypes
- Indicates functional antibody-mediated immunity
High antibody levels (strong immune response)
- Elevated IgG levels across many or all serotypes
- UK standard: Values above protective thresholds
- Often reflects recent vaccination or strong immune memory
How It Works
Simple steps to get your results
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Choose your test online and book in seconds. Select your preferred clinic location or home visit option.
Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
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WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.