Syphilis by PCR (Chancre)
This PCR test detects syphilis directly from a chancre using a lesion swab. It allows early and accurate diagnosis before blood antibodies develop.
Turnaround time
Results available 5 days after arrival in lab. Doctor's report sent the day after results available (if required)
Biomarkers count
1
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Details about Syphilis by PCR (Chancre)
What is the Syphilis PCR (Chancre) Test?
The Syphilis PCR (Chancre) test is a molecular test that detects the DNA of Treponema pallidum, the bacterium that causes syphilis, directly from a chancre (syphilitic sore). A swab is taken from the lesion and analysed using PCR technology, which is highly sensitive and specific.
Unlike blood tests that rely on antibody formation, PCR identifies the infection at the site of active disease. This makes it particularly valuable in very early syphilis, when blood tests may still be negative.
The test is most effective when a fresh, untreated chancre is present.
Why do I need a Syphilis PCR test?
Syphilis can be difficult to diagnose in its early stages because symptoms may be mild and blood antibodies may not yet be detectable. Testing the chancre itself provides direct confirmation of infection.
You may need this test if you have:
- A painless genital, anal, or oral ulcer
- A sore that appeared after sexual contact
- A lesion that does not heal within 1–3 weeks
- Suspected primary syphilis
- Negative or inconclusive blood tests with a visible chancre
- Recent high-risk sexual exposure with a lesion present
Early detection is crucial to prevent progression to secondary or latent syphilis, which can cause serious long-term complications.
Benefits of the test
- Direct detection at the source
Identifies the bacterium directly from the chancre. - Highly sensitive early diagnosis
Detects infection before antibodies develop. - Greater accuracy than blood tests in early disease
Reduces false-negative results in primary syphilis. - Rapid molecular confirmation
PCR provides precise organism identification. - Useful when blood results are unclear
Clarifies diagnosis in early or atypical cases. - Supports prompt clinical decision-making
Enables earlier intervention and follow-up. - Reduces onward transmission risk
Early diagnosis helps limit spread to partners. - Targeted testing for visible lesions
Ideal when a chancre is present and accessible.
Step-by-step: How we offer testing
Clinic-based testing (UK-wide)
- Choose your nearest UK clinic
- Attend your appointment
- A clinician swabs the chancre lesion
- Sample is sent to the laboratory
- Results are issued once analysis is complete
Home or hotel visit (+£60, UK-wide)
- Book a mobile clinician
- Chancre swab taken at your home or hotel
- No clinic visit required
- Sample securely transported to the laboratory
Your results explained
Not detected (negative)
- No Treponema pallidum DNA identified
- UK standard: Not detected
- Suggests the lesion is not due to syphilis or sampling was too late
Low-level detection
- Small quantities of bacterial DNA detected
- UK standard: Low positive / equivocal
- May reflect very early infection or partial healing
Detected (positive)
- Treponema pallidum DNA identified
- UK standard: Detected
- Confirms active syphilis infection at the lesion site
How It Works
Simple steps to get your results
Book Online
Choose your test online and book in seconds. Select your preferred clinic location or home visit option.
Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
Take control of your health with London Blood Tests
WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.