What is the Thyroid Full Profile?

The Thyroid Full Profile is an in-depth blood test that evaluates both thyroid hormone production and autoimmune activity affecting the thyroid gland. It provides a complete picture of how the thyroid is functioning and whether the immune system is involved.

This profile includes Thyroxine (T4), Free T3, Free T4, Thyroid Stimulating Hormone (TSH), Antithyroglobulin Antibodies (TgAb), and Thyroid Peroxidase Antibodies (TPOAb). Together, these markers assess hormone output, hormone availability, pituitary signalling, and autoimmune thyroid disease.

It is particularly useful when symptoms persist despite normal basic thyroid tests or when autoimmune thyroid disease is suspected.

Why do I need a Thyroid Full Profile?

Thyroid disorders can present with broad, non-specific symptoms and may be missed by single-marker testing. Autoimmune thyroid disease can also be present before hormone levels become abnormal.

You may benefit from this test if you experience:

• Persistent fatigue or low energy
• Weight gain or unexplained weight loss
• Cold or heat intolerance
• Hair thinning or hair loss
• Anxiety, low mood, or brain fog
• Palpitations or tremors
• Irregular menstrual cycles or fertility concerns
• Family history of thyroid or autoimmune disease
• Fluctuating or borderline thyroid results

This profile helps distinguish functional thyroid problems from immune-related thyroid disease and supports clearer clinical interpretation.

Benefits of the test

1. Complete thyroid assessment
   Measures pituitary signalling, hormone levels, and immune antibodies together.
2. Detects autoimmune thyroid disease
   Identifies Hashimoto’s- and Graves’-related antibody activity.
3. Explains symptoms with normal TSH
   Free hormone and antibody testing adds critical context.
4. Identifies early or subclinical disease
   Antibodies may appear before hormone disruption.
5. Supports fertility and pregnancy planning
   Thyroid balance is crucial for reproductive health.
6. Useful for long-term monitoring
   Tracks hormonal and immune trends over time.
7. Improves diagnostic confidence
   Reduces reliance on single-marker interpretation.
8. Single blood draw
   Comprehensive results from one sample.

Step-by-step: How we offer testing

Clinic-based testing (UK-wide)

• Choose your nearest UK clinic
• Attend your appointment
• A clinician draws a blood sample
• Sample is sent to the laboratory
• Results are issued once analysis is complete

Home or hotel visit (+£60, UK-wide)

• Book a mobile phlebotomist
• Blood sample taken at your home or hotel
• No need to attend a clinic
• Sample securely transported to the laboratory

Your results explained

Low thyroid function (hypothyroid pattern)

• High TSH with low Free T4 and/or Free T3
• UK standards (typical):
• TSH: >4.5 mIU/L
• Free T4: <10 pmol/L
• May be associated with fatigue, weight gain, cold intolerance

Normal thyroid function (euthyroid)

• Balanced TSH, Free T4, and Free T3
• UK standards (typical):
• TSH: 0.4–4.0 mIU/L
• Free T4: 10–22 pmol/L
• Free T3: 3.1–6.8 pmol/L
• Suggests normal hormone production and regulation

High thyroid function (hyperthyroid pattern)

• Low TSH with elevated Free T4 and/or Free T3
• UK standards (typical):
• TSH: <0.1 mIU/L
• Free T4: >22 pmol/L
• May be associated with palpitations, anxiety, heat intolerance

Autoimmune activity present

• Elevated TPOAb and/or TgAb
• UK standards (typical):
• TPOAb: >35 IU/mL
• TgAb: >115 IU/mL
• Indicates immune-mediated thyroid disease even if hormones are normal

Results should always be interpreted together, not in isolation.