What is the Tiredness / Fatigue Profile?

The Tiredness / Fatigue Profile is a comprehensive blood test designed to identify common physiological causes of ongoing tiredness, weakness, or low energy. Fatigue is often multifactorial, and single tests may miss contributing factors.

This profile includes liver function markers, full blood count, thyroid hormones, iron status, and vitamin D. Together, these tests assess oxygen delivery, hormone balance, nutrient status, liver health, and immune or inflammatory signals that commonly contribute to fatigue.

It is suitable for both initial investigation and follow-up when symptoms persist without a clear explanation.

Why do I need a Tiredness / Fatigue Profile?

Fatigue is one of the most common medical complaints and can arise from subtle imbalances that are not obvious without blood testing. Many underlying causes overlap in symptoms.

You may benefit from this profile if you experience:

• Persistent tiredness or low energy
• Weakness or reduced stamina
• Brain fog or poor concentration
• Pale skin or shortness of breath
• Sleep issues despite adequate rest
• Low mood or lack of motivation
• Frequent infections or slow recovery
• Unexplained aches or headaches

This profile helps identify whether fatigue is linked to anaemia, thyroid dysfunction, liver issues, iron imbalance, or vitamin deficiency.

Benefits of the test

1. Broad fatigue investigation
   Assesses multiple systems commonly linked to tiredness.
2. Identifies anaemia and blood disorders
   Full blood count evaluates oxygen-carrying capacity.
3. Checks thyroid-related fatigue
   Detects underactive thyroid patterns.
4. Assesses iron availability
   Identifies iron deficiency or impaired iron binding.
5. Evaluates liver health
   Liver dysfunction can significantly impact energy levels.
6. Detects vitamin D deficiency
   Low levels are commonly associated with fatigue.
7. Single blood draw
   Multiple causes assessed from one sample.
8. Supports targeted follow-up
   Results guide further investigation if needed.

Step-by-step: How we offer testing

Clinic-based testing (UK-wide)

• Choose your nearest UK clinic
• Attend your appointment
• A clinician draws a blood sample
• Sample is sent to the laboratory
• Results are issued once analysis is complete

Home or hotel visit (+£60, UK-wide)

• Book a mobile phlebotomist
• Blood sample taken at your home or hotel
• No need to attend a clinic
• Sample securely transported to the laboratory

Your results explained

Low or abnormal results (possible cause of fatigue)

• Low haemoglobin / red cells – suggests anaemia
• Low iron or high TIBC – indicates iron deficiency
• Raised TSH / low Free T4 – suggests underactive thyroid
• Low vitamin D – associated with muscle weakness and fatigue
• Abnormal liver enzymes – may affect metabolism and energy

Typical UK reference examples (may vary by lab):

• Haemoglobin (women): <120 g/L
• Haemoglobin (men): <130 g/L
• TSH: >4.5 mIU/L
• Vitamin D: <50 nmol/L

Normal results

• Blood count, liver enzymes, thyroid hormones, iron, and vitamin D within reference ranges
• Suggests fatigue may be related to lifestyle, sleep, stress, or non-blood-test causes

High results (context-dependent)

• Raised liver enzymes – may indicate liver stress or inflammation
• High iron levels – may suggest iron overload or supplementation effects
• Elevated white cells – may indicate infection or inflammation

Results should always be interpreted together rather than in isolation.