Tiredness/Fatigue Profile
This fatigue profile investigates common medical causes of persistent tiredness and low energy. It combines liver, blood, thyroid, iron, and vitamin testing in one assessment.
Turnaround time
2 days
Biomarkers count
28
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Details about Tiredness/Fatigue Profile
What is the Tiredness / Fatigue Profile?
The Tiredness / Fatigue Profile is a comprehensive blood test designed to identify common physiological causes of ongoing tiredness, weakness, or low energy. Fatigue is often multifactorial, and single tests may miss contributing factors.
This profile includes liver function markers, full blood count, thyroid hormones, iron status, and vitamin D. Together, these tests assess oxygen delivery, hormone balance, nutrient status, liver health, and immune or inflammatory signals that commonly contribute to fatigue.
It is suitable for both initial investigation and follow-up when symptoms persist without a clear explanation.
Why do I need a Tiredness / Fatigue Profile?
Fatigue is one of the most common medical complaints and can arise from subtle imbalances that are not obvious without blood testing. Many underlying causes overlap in symptoms.
You may benefit from this profile if you experience:
- Persistent tiredness or low energy
- Weakness or reduced stamina
- Brain fog or poor concentration
- Pale skin or shortness of breath
- Sleep issues despite adequate rest
- Low mood or lack of motivation
- Frequent infections or slow recovery
- Unexplained aches or headaches
This profile helps identify whether fatigue is linked to anaemia, thyroid dysfunction, liver issues, iron imbalance, or vitamin deficiency.
Benefits of the test
- Broad fatigue investigation
Assesses multiple systems commonly linked to tiredness. - Identifies anaemia and blood disorders
Full blood count evaluates oxygen-carrying capacity. - Checks thyroid-related fatigue
Detects underactive thyroid patterns. - Assesses iron availability
Identifies iron deficiency or impaired iron binding. - Evaluates liver health
Liver dysfunction can significantly impact energy levels. - Detects vitamin D deficiency
Low levels are commonly associated with fatigue. - Single blood draw
Multiple causes assessed from one sample. - Supports targeted follow-up
Results guide further investigation if needed.
Step-by-step: How we offer testing
Clinic-based testing (UK-wide)
- Choose your nearest UK clinic
- Attend your appointment
- A clinician draws a blood sample
- Sample is sent to the laboratory
- Results are issued once analysis is complete
Home or hotel visit (+£60, UK-wide)
- Book a mobile phlebotomist
- Blood sample taken at your home or hotel
- No need to attend a clinic
- Sample securely transported to the laboratory
Your results explained
Low or abnormal results (possible cause of fatigue)
- Low haemoglobin / red cells – suggests anaemia
- Low iron or high TIBC – indicates iron deficiency
- Raised TSH / low Free T4 – suggests underactive thyroid
- Low vitamin D – associated with muscle weakness and fatigue
- Abnormal liver enzymes – may affect metabolism and energy
Typical UK reference examples (may vary by lab):
- Haemoglobin (women): <120 g/L
- Haemoglobin (men): <130 g/L
- TSH: >4.5 mIU/L
- Vitamin D: <50 nmol/L
Normal results
- Blood count, liver enzymes, thyroid hormones, iron, and vitamin D within reference ranges
- Suggests fatigue may be related to lifestyle, sleep, stress, or non-blood-test causes
High results (context-dependent)
- Raised liver enzymes – may indicate liver stress or inflammation
- High iron levels – may suggest iron overload or supplementation effects
- Elevated white cells – may indicate infection or inflammation
Results should always be interpreted together rather than in isolation.
How It Works
Simple steps to get your results
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Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
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WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.