Tissue Transglutaminase IgA (Coeliac)
Private Tissue Transglutaminase IgA testing in London for £99, measuring one coeliac-related antibody marker with results expected in around 2 days.
Turnaround time
2 business days
Biomarkers count
1
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Overview of the Tissue Transglutaminase IgA (Coeliac) Test
The Tissue Transglutaminase IgA blood test measures IgA antibodies directed against tissue transglutaminase, an enzyme that becomes an important autoimmune target in coeliac disease.
The test assesses 1 specialist autoimmune marker: Tissue Transglutaminase IgA (Coeliac).
Coeliac disease is an autoimmune condition in which eating gluten triggers an immune reaction that damages the lining of the small intestine.
Gluten is found naturally in wheat, barley and rye.
Tissue transglutaminase, commonly abbreviated to tTG, is involved in tissue repair and modifies gluten-derived proteins within the intestinal lining.
In coeliac disease, the immune system can produce antibodies against tissue transglutaminase.
Tissue Transglutaminase IgA is therefore one of the principal blood markers used during initial coeliac disease assessment.
For people who produce normal amounts of Immunoglobulin A, tTG-IgA is generally the preferred first-line serological test.
However, Total IgA is important because people with IgA deficiency may produce a falsely reassuring tTG-IgA result.
Where IgA deficiency is present, an IgG-based coeliac antibody such as Tissue Transglutaminase IgG or Deamidated Gliadin IgG may be more appropriate.
The accuracy of coeliac serology also depends on continued gluten consumption before testing.
If somebody has already removed gluten from their diet, antibody concentrations can fall and the test can become negative despite underlying coeliac disease.
A positive tTG-IgA result can strongly support coeliac autoimmunity, particularly when the antibody concentration is substantially elevated.
However, the result must be interpreted with symptoms, Total IgA, other coeliac antibodies and clinical guidance.
Depending on the result and clinical setting, further investigation may include Endomysial Antibodies, specialist gastroenterology review or small-bowel biopsy.
What Does the Tissue Transglutaminase IgA (Coeliac) Test Check?
The test detects IgA antibodies directed against tissue transglutaminase and provides laboratory evidence relevant to coeliac disease. This test measures 1 specialist biomarker.
Tissue Transglutaminase IgA (Coeliac)
Measures IgA autoantibodies against tissue transglutaminase, supporting first-line investigation of coeliac disease in people who are consuming gluten and have adequate Total IgA.
Who May Benefit From the Tissue Transglutaminase IgA (Coeliac) Test?
tTG-IgA testing can be useful where coeliac disease is suspected from symptoms, nutritional abnormalities or family history.
People with persistent diarrhoea or gastrointestinal symptoms - Coeliac disease can cause chronic bowel symptoms through immune-mediated small-intestinal damage.
People with unexplained iron deficiency or anaemia - Reduced intestinal absorption can make iron deficiency one of the presenting features of coeliac disease.
People with persistent bloating or abdominal discomfort - These symptoms can occur with coeliac disease but also have many other possible causes.
People with unexplained Folate or other nutritional deficiencies - Small-intestinal damage can interfere with nutrient absorption.
People with a first-degree relative with coeliac disease - Family members have a higher likelihood of developing the condition.
People with type 1 diabetes or autoimmune thyroid disease - Coeliac disease occurs more frequently alongside selected autoimmune disorders.
People with dermatitis herpetiformis or another clinically compatible presentation - Coeliac serology can contribute to a wider diagnostic assessment.
People with previous borderline or incomplete coeliac testing - tTG-IgA and Total IgA can help clarify the serological picture.
How to Prepare
The reliability of coeliac serology depends on sufficient gluten exposure before testing.
If you have already been gluten-free for a prolonged period, speak with a clinician before deliberately reintroducing gluten.
Symptoms and Reasons to Consider the Tissue Transglutaminase IgA (Coeliac) Test
Coeliac disease can cause gastrointestinal, nutritional and systemic symptoms, although some people have few obvious digestive complaints.
Persistent diarrhoea or loose stools - Small-intestinal inflammation can affect normal digestion and absorption.
Abdominal bloating or discomfort - Coeliac disease can produce recurrent gastrointestinal symptoms.
Unexplained iron-deficiency anaemia - Iron absorption occurs mainly in the proximal small intestine and can be impaired in coeliac disease.
Persistent fatigue - Anaemia and nutritional deficiency can contribute to tiredness.
Unintentional weight loss - More significant malabsorption can affect body weight.
Mouth ulcers or nutritional deficiencies - Folate, iron and other micronutrient abnormalities can accompany untreated coeliac disease.
An itchy blistering rash compatible with dermatitis herpetiformis - This skin condition is closely associated with coeliac disease.
A family history of confirmed coeliac disease - Testing can be appropriate even when symptoms are mild or atypical.
A negative tTG-IgA result does not reliably exclude coeliac disease if you have already stopped eating gluten or if you have IgA deficiency.
Do not start a gluten-free diet solely to improve symptoms before appropriate diagnostic testing has been completed, unless a clinician has specifically advised you to do so.
How to Book Your Tissue Transglutaminase IgA (Coeliac) Test
The Tissue Transglutaminase IgA test can be booked privately for focused coeliac disease serology.
Choose the Tissue Transglutaminase IgA (Coeliac)
Select the individual tTG-IgA blood test online.
Select your sample collection option
Choose an in-clinic blood draw or professional home or hotel phlebotomy where suitable.
Attend your appointment
A trained healthcare professional collects the required venous blood sample and relevant gluten intake can be documented.
Laboratory analysis
Your serum undergoes measurement of Tissue Transglutaminase IgA (Coeliac).
Receive your results securely
Your authorised result is delivered securely and can be interpreted alongside Total IgA and other coeliac investigations where appropriate.
When Will I Receive My Results?
The current live London Blood Tests page lists a turnaround of approximately 2 days after laboratory receipt for Tissue Transglutaminase IgA (Coeliac).
The sample undergoes immunological antibody analysis, laboratory quality-control procedures and result authorisation.
Turnaround begins when the specimen reaches the laboratory rather than necessarily from the exact time of collection.
Additional Endomysial Antibody or specialist coeliac investigations can take longer if further testing is required.
Understanding Your Results
A negative result means significant tTG-IgA antibodies were not detected according to the laboratory assay.
Where Total IgA is normal and the person has been consuming sufficient gluten, this makes active coeliac disease less likely.
A negative result is less reliable in somebody with IgA deficiency or somebody who has already restricted gluten.
A positive result indicates increased IgA antibodies against tissue transglutaminase.
Higher concentrations can provide stronger laboratory support for coeliac autoimmunity.
The result should not be interpreted without considering Total IgA and the person's clinical presentation.
Endomysial Antibodies may be used as an additional highly specific antibody test.
Depending on age, antibody level and clinical circumstances, gastroenterology assessment and small-bowel biopsy may also be required before a formal diagnosis is established.
The laboratory's own validated interpretation should take priority over generic cut-off values.
Why Book With London Blood Tests?
London Blood Tests provides private access to first-line coeliac antibody testing for people requiring focused autoimmune gastrointestinal assessment.
Measures the principal IgA coeliac antibody - tTG-IgA is widely used as a first-line serological marker for coeliac disease.
Useful in gastrointestinal and nutritional assessment - Coeliac disease can present through digestive symptoms, anaemia or micronutrient deficiency.
Can complement Total IgA - Total Immunoglobulin A helps establish whether IgA-based antibody testing is reliable.
Can complement Endomysial Antibodies - EMA can provide additional coeliac-specific serological information.
Relevant to family screening - Coeliac disease occurs more frequently among first-degree relatives.
Rapid laboratory turnaround - Results are expected approximately 2 days after laboratory receipt.
Professional blood collection - Clinic and suitable home or hotel phlebotomy appointments are available.
Clear pricing - The Tissue Transglutaminase IgA test costs £99.
Private Tissue Transglutaminase IgA (Coeliac) Blood Test in London
London Blood Tests provides private Tissue Transglutaminase IgA testing for people requiring focused assessment for coeliac autoimmunity.
The test costs £99 and measures 1 specialist biomarker.
Results are expected approximately 2 days after laboratory receipt.
For reliable interpretation, the test should usually be performed while gluten remains in the diet and Total IgA status should be considered.