What is the TRT Panel?

The TRT Panel (Testosterone Replacement Therapy Panel) is a specialised blood test designed to evaluate male hormone levels and monitor individuals undergoing testosterone replacement therapy. Testosterone plays a critical role in male health, influencing muscle mass, energy levels, libido, mood, metabolic health and bone density.

When testosterone levels decline due to ageing, medical conditions or endocrine dysfunction, symptoms such as fatigue, reduced muscle strength, low libido and cognitive changes may occur. TRT can help restore hormonal balance, but it must be carefully monitored to ensure that hormone levels remain within safe physiological ranges.

This panel evaluates testosterone levels, pituitary hormones, metabolic markers, cardiovascular risk markers, liver and kidney function, inflammation markers and essential nutrients. By analysing these biomarkers together, clinicians can assess whether TRT is appropriate, monitor treatment safety and adjust therapy if needed.

Biomarkers Included in the TRT Panel

Haematology – Full Blood Count (FBC)

The full blood count evaluates blood cell production, oxygen transport and immune health.

Includes:

• Haemoglobin (Hb)

• Red Blood Cell Count (RBC)

• White Blood Cell Count (WBC)

• Platelet Count (PLT)

• Haematocrit Level (HCT)

• Mean Cell Volume (MCV)

• Mean Cell Haemoglobin (MCH)

• Mean Cell Haemoglobin Concentration (MCHC)

• Red Blood Cell Distribution Width (RDW)

• Mean Platelet Volume (MPV)

• Neutrophils

• Lymphocytes

• Monocytes

• Eosinophils

• Basophils

Testosterone & Hormonal Markers

These biomarkers evaluate androgen status and hormone regulation.

• Total Testosterone

• Free Testosterone

• Sex Hormone Binding Globulin (SHBG)

• Luteinising Hormone (LH)

• Follicle Stimulating Hormone (FSH)

• Prolactin

• Cortisol

• Albumin

Albumin is included because it helps calculate bioavailable testosterone.

Thyroid Function

Thyroid hormones influence metabolism, energy levels and hormone balance.

• Thyroid Stimulating Hormone (TSH)

• Free T3 (FT3)

• Free T4 (FT4)

Lipid Profile (Cardiovascular Health)

TRT can influence cholesterol metabolism, making lipid monitoring important.

• Total Cholesterol

• HDL Cholesterol

• LDL Cholesterol

• Triglycerides

• Apolipoprotein B (ApoB)

Liver Function (LFT)

The liver metabolises hormones and medications.

Includes:

• ALT

• AST

• ALP

• GGT

• Bilirubin

• Albumin

• Total Protein

Kidney Function (Urea & Electrolytes)

These markers evaluate kidney filtration and metabolic balance.

• Creatinine

• eGFR

• Urea

• Sodium

• Potassium

• Chloride

• Bicarbonate

Prostate Health

• Prostate Specific Antigen (PSA)

PSA monitoring is important for men receiving testosterone therapy.

Nutrients & Iron Status

These biomarkers evaluate nutritional health and iron stores.

• Vitamin D

• Ferritin

Why do I need a TRT blood test?

Testosterone levels naturally decline with age, but low testosterone can also occur due to endocrine disorders, metabolic conditions or lifestyle factors. TRT is often prescribed to restore hormone balance and improve symptoms, but it requires careful medical supervision.

A TRT blood test helps determine whether testosterone levels are low and whether hormone therapy may be appropriate. It also monitors safety markers during treatment to ensure that therapy does not negatively affect other systems such as cardiovascular health, liver function or prostate health.

Common symptoms associated with low testosterone include:

• Low libido

• Erectile dysfunction

• Fatigue and low energy

• Reduced muscle mass

• Increased body fat

• Brain fog or reduced concentration

• Mood changes or irritability

• Reduced exercise performance

• Poor recovery from training

• Sleep disturbances

Monitoring TRT also helps detect possible side effects such as increased red blood cell production, changes in cholesterol levels or elevated PSA levels.

Regular testing allows clinicians to optimise testosterone dosing while maintaining safe physiological levels.

Benefits of the TRT Panel

1. Accurate testosterone assessment
Measures both total and free testosterone to evaluate androgen status.

2. Determines cause of low testosterone
Pituitary hormones such as LH and FSH help identify whether the cause is primary or secondary hypogonadism.

3. Monitors therapy safety
Regular testing ensures testosterone levels remain within safe ranges.

4. Cardiovascular risk monitoring
Lipid markers and ApoB help evaluate cholesterol changes during TRT.

5. Prostate health monitoring
PSA helps monitor prostate health in men receiving testosterone therapy.

6. Organ function evaluation
Liver and kidney markers confirm metabolic health during treatment.

7. Nutritional status insights
Vitamin D and ferritin levels help detect deficiencies that may worsen fatigue or hormonal symptoms.

8. Personalised treatment adjustments
Results help clinicians optimise TRT dosing for better symptom control and safety.

Step by Step

We offer two convenient ways to take this test anywhere in the UK.

Option 1 – Visit a Clinic

• Choose your nearest UK clinic when booking

• Attend your appointment

• A trained healthcare professional collects your blood sample

• Samples are sent to the laboratory for analysis

• Results are delivered securely

Option 2 – Home or Hotel Visit

For £60 extra, a trained phlebotomist can visit your location.

• Book online

• A phlebotomist travels to your home, office or hotel

• Your blood sample is collected safely and professionally

• No need to travel

Both services are available UK-wide.

Your Results Explained

Low Levels

Low testosterone levels may indicate hypogonadism or hormonal imbalance.

Typical reference examples:

• Total Testosterone: below ~8–12 nmol/L may indicate deficiency

• Vitamin D: deficiency typically below 25 nmol/L

• Ferritin: low levels may suggest depleted iron stores

Symptoms may include fatigue, reduced libido, decreased muscle mass and mood changes.

Normal Levels

Normal hormone levels indicate balanced endocrine function.

Typical UK ranges include:

• Testosterone: approximately 12–30 nmol/L in adult men

• TSH: 0.4 – 4.0 mIU/L

• HbA1c: below 42 mmol/mol

• CRP: below 3 mg/L

Maintaining optimal hormone levels supports energy, muscle health and metabolic balance.

High Levels

Elevated biomarkers may indicate excessive hormone exposure or metabolic changes.

Examples include:

• Haematocrit: elevated levels may occur during TRT due to increased red blood cell production

• PSA: levels above ~4 ng/mL may require further evaluation

• ALT/AST: elevated levels may indicate liver stress

• LDL Cholesterol: high levels may increase cardiovascular risk

Further medical evaluation may be recommended if abnormal results are detected.