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Valproic Acid (Epilim)

Toxicology and Exposure
89.00

The Valproic Acid (Epilim) test measures blood levels of valproate to ensure safe and effective treatment. It is used for therapeutic drug monitoring and dose optimisation.

Turnaround time

1-2 days

Biomarkers count

1

Same-Day Appointments
UKAS Accredited Labs

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Under 18? Patients under 18 can only be seen at GB Medlabs and Clinilabs, Monday to Friday only.
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Details about Valproic Acid (Epilim)

What is the Valproic Acid (Epilim) test?

The Valproic Acid (Epilim) test measures the concentration of valproate in the bloodstream. Valproic acid is an antiepileptic and mood-stabilising medication used in conditions such as epilepsy, bipolar disorder, and migraine prevention.

Because valproate has a defined therapeutic range, monitoring blood levels helps ensure the dose is effective without causing adverse effects. Levels can vary due to dosing schedule, metabolism, interactions with other medicines, and liver function.

This test is part of therapeutic drug monitoring (TDM) and is often timed in relation to dosing (usually a trough level).

 

Why do I need a Valproic Acid test?

Blood level monitoring is essential to balance seizure or symptom control with medication safety.

You may need this test if you:

  • Are starting valproic acid therapy
  • Require dose adjustment
  • Have breakthrough seizures or symptom relapse
  • Experience side effects (e.g., drowsiness, tremor, nausea)
  • Are taking interacting medications
  • Have liver function concerns
  • Need routine monitoring during long-term therapy

Providing dosing time and dose details improves result interpretation.

 

Benefits of the test

  1. Optimises treatment effectiveness
    Confirms levels are within the therapeutic range.
  2. Reduces toxicity risk
    Helps avoid high valproate concentrations.
  3. Supports dose adjustment
    Guides safe titration.
  4. Essential for long-term therapy
    Standard monitoring for ongoing use.
  5. Accounts for individual metabolism
    Personalises dosing.
  6. Simple blood-based testing
    Requires only one blood sample.
  7. Widely used in clinical practice
    Standard in neurology and psychiatry.
  8. Improves treatment safety
    Early detection of abnormal levels.

 

Step-by-step: How we offer testing

Clinic-based testing (UK-wide)

  • Choose your nearest UK clinic
  • Attend your appointment
  • Blood sample taken at the appropriate time (usually pre-dose)
  • Clinical details recorded (dose, timing)
  • Sample sent to the laboratory

Home or hotel visit (+£60, UK-wide)

  • Mobile phlebotomist arranged where appropriate
  • Blood drawn at the correct time relative to dosing
  • Sample securely transported to the laboratory

 

Your results explained

Low level (sub-therapeutic)

  • Valproate below target range
  • UK standard (typical): <50 mg/L
  • May reduce seizure or symptom control

Therapeutic level

  • Valproate within target range
  • UK standard (typical): 50–100 mg/L
  • Suggests appropriate dosing

High level (toxicity risk)

  • Valproate above recommended range
  • UK standard: >100 mg/L
  • Increased risk of side effects and toxicity

Target ranges may vary by indication and clinical context.

How It Works

Simple steps to get your results

1

Book Online

Choose your test online and book in seconds. Select your preferred clinic location or home visit option.

2

Visit or Test at Home

Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.

3

Get Your Results

Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.

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How to Prepare for Your Test

Follow these guidelines for accurate results

Sample Timing

Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.

Fasting & Hydration

Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.

Medications & Supplements

Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.

Hormones & Menstrual Cycle

For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.

If you have any questions or special circumstances, our team is happy to advise before your appointment.

Frequently Asked Questions

To ensure effectiveness while avoiding toxicity.

Usually just before the next dose (trough level).

Yes, clinical response varies between individuals.

Yes, valproate is metabolised by the liver.

Yes, some drugs interact with valproate.

Yes, it is a core monitoring test.

Yes, periodic testing is recommended.

Yes, illness, weight change, and interactions can alter levels.

Fasting is not usually required.

It indicates increased toxicity risk and supports dose review.

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