Varicella Zoster (DNA)
The Varicella Zoster (DNA) test detects the genetic material of the varicella zoster virus. It is used to confirm active chickenpox or shingles infection.
Turnaround time
Results available 5 days after arrival in lab. Doctor's report sent the day after results available (if required)
Biomarkers count
1
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Details about Varicella Zoster (DNA)
What is the Varicella Zoster (DNA) test?
The Varicella Zoster (DNA) test is a PCR-based test that detects the presence of varicella zoster virus (VZV) genetic material in a sample. VZV is the virus responsible for chickenpox (primary infection) and shingles (reactivation).
PCR testing is highly sensitive and can confirm active infection even at early stages or when symptoms are atypical. Samples are usually taken from a skin lesion, blister, or swab, depending on presentation.
This test confirms active viral replication rather than past exposure.
Why do I need a Varicella Zoster (DNA) test?
Symptoms of VZV infection can overlap with other viral or skin conditions. PCR testing provides definitive confirmation.
You may need this test if you experience:
- Painful blistering rash
- Localised rash following a nerve pathway
- Suspected shingles
- Atypical or mild rash
- Complications involving eyes or face
- Symptoms in immunocompromised individuals
- Need to distinguish shingles from herpes simplex
- Unclear rash diagnosis
Accurate diagnosis supports timely clinical management and infection control decisions.
Benefits of the test
- Confirms active VZV infection
Detects viral DNA directly. - Highly sensitive and specific
PCR is the gold standard for diagnosis. - Differentiates from other viruses
Helps distinguish shingles from herpes simplex. - Useful in early or atypical cases
Detects virus before classic features develop. - Supports clinical decision-making
Confirms cause of rash or neurological symptoms. - Suitable for immunocompromised patients
Important where symptoms may be subtle. - Rapid and accurate testing
Provides reliable results from small samples. - Reduces diagnostic uncertainty
Avoids unnecessary or incorrect treatment.
Step-by-step: How we offer testing
Clinic-based testing (UK-wide)
- Choose your nearest UK clinic
- Lesion or swab sample collected by a clinician
- Sample sent to the laboratory for PCR analysis
- Results issued once testing is complete
Home or hotel visit (+£60, UK-wide)
- Sample collected at home or hotel where appropriate
- Lesion or swab sample obtained
- Sample securely transported to the laboratory
Your results explained
Negative result
- Varicella zoster DNA not detected
- UK standard: Negative
- No evidence of active VZV infection
Positive result
- Varicella zoster DNA detected
- UK standard: Positive
- Confirms active chickenpox or shingles infection
Results should be interpreted alongside clinical symptoms and timing of sample collection.
How It Works
Simple steps to get your results
Book Online
Choose your test online and book in seconds. Select your preferred clinic location or home visit option.
Visit or Test at Home
Attend one of our UK or London clinics, arrange a home nurse visit, or use a finger-prick kit where available.
Get Your Results
Your sample is analysed by accredited UK laboratories, with secure results delivered directly to you.
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WhatsApp UsHow to Prepare for Your Test
Follow these guidelines for accurate results
Sample Timing
Where possible, attend your blood test between 7am and 12pm. Please wait until any short-term illness or infection has fully resolved before testing. Avoid intense exercise for 24–48 hours beforehand, as this can affect certain markers.
Fasting & Hydration
Fasting is not always required, but some tests may recommend it. If fasting is advised, avoid food for 8–12 hours before your appointment and drink water only. Stay well hydrated, as this helps with sample collection and accuracy.
Medications & Supplements
Continue prescribed medications unless advised otherwise by your clinician. Avoid vitamin, mineral, or biotin supplements for at least 24–48 hours before your test, as these can interfere with results. If you are unsure about any medication or supplement, please let us know before your appointment.
Hormones & Menstrual Cycle
For hormone-related tests, timing within your menstrual cycle may be important. If relevant, follow any specific guidance provided on your test page.
If you have any questions or special circumstances, our team is happy to advise before your appointment.