Miscarriage Profile
Specialist miscarriage testing covering clotting, thrombophilia, antiphospholipid antibodies and maternal chromosome analysis.
Turnaround time
21 business days
Biomarkers count
12
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Overview of the Miscarriage Profile Test
The Miscarriage Profile is a specialist blood and genetic profile designed to investigate selected clotting, thrombophilia, antiphospholipid and chromosomal factors that may be relevant following recurrent pregnancy loss.
Pregnancy loss can occur for many different reasons.
Possible contributors can include chromosomal abnormalities, uterine or anatomical factors, hormonal or metabolic conditions, antiphospholipid syndrome and other maternal or pregnancy-related factors.
In many cases, no single cause is identified.
This profile therefore does not claim to determine the cause of miscarriage from one blood test.
Instead, it combines haematology, coagulation testing, inherited thrombophilia markers, antiphospholipid-related investigations and maternal chromosome analysis within one specialist profile.
The current laboratory profile contains 12 grouped investigations.
Maternal chromosome analysis is included.
If chromosome analysis is also required for a partner, the partner's Chromosome Analysis must be requested separately.
The Miscarriage Profile costs £1,438.
What Does the Miscarriage Profile Test Check?
The Miscarriage Profile contains 12 grouped laboratory investigations covering haematology, coagulation, thrombophilia, antiphospholipid antibodies and maternal chromosome analysis.
Full Blood Count (FBC) - Assesses red cells, white cells and platelets and provides a general haematological baseline.
Coagulation Profile - Assesses important components of blood-clotting function.
Fibrinogen - Measures fibrinogen, a key protein involved in formation of blood clots.
Antithrombin III - Measures an important natural anticoagulant protein.
Factor V Leiden Common Variant - Tests for the common inherited Factor V Leiden variant associated with increased venous thrombosis risk.
Factor II Prothrombin Common Variant - Tests for a common inherited Prothrombin variant associated with increased clotting tendency.
MTHFR Common Variants - Assesses the common MTHFR variants included within the laboratory profile. These variants should not be interpreted as independently establishing the cause of miscarriage.
Protein C - Measures Protein C, one of the body's natural anticoagulant proteins.
Free Protein S Antigen - Measures free Protein S, another component of the natural anticoagulant system.
Lupus Anticoagulant - Assesses laboratory evidence relevant to antiphospholipid syndrome.
Anticardiolipin Antibodies - Measures antibodies used as part of antiphospholipid syndrome investigation.
Chromosome Analysis - Examines maternal chromosome number and visible chromosome structure for selected abnormalities or rearrangements.
Who May Benefit From the Miscarriage Profile Test?
The Miscarriage Profile is principally intended for women undergoing specialist investigation following recurrent pregnancy loss.
Women who have experienced recurrent miscarriage - The profile investigates selected maternal clotting, antibody and chromosome factors.
Women advised to undergo thrombophilia assessment - Several inherited and acquired clotting investigations are included.
Women being investigated for antiphospholipid syndrome - Lupus Anticoagulant and Anticardiolipin Antibodies form part of the profile.
Women with a personal history of thrombosis - Clinical history may increase the relevance of specialist thrombophilia assessment.
Women with a family history of inherited thrombophilia - Genetic and coagulation testing may be relevant where appropriate.
Women requiring maternal chromosome analysis - Chromosome Analysis is incorporated within the profile.
Women referred by a fertility or recurrent-miscarriage specialist - The results can form one part of a broader investigation.
Symptoms and Reasons to Consider the Miscarriage Profile Test
The profile is generally considered because of pregnancy history rather than one specific symptom.
Two or more pregnancy losses requiring specialist review - Clinical definitions and investigation thresholds can vary, so appropriate reproductive assessment is important.
A previous pregnancy loss with concerning clinical features - Individual circumstances may justify earlier specialist investigation.
A personal history of venous thrombosis - This may increase the relevance of selected thrombophilia testing.
A known family thrombophilia - Targeted investigation may be appropriate according to clinical history.
Previous abnormal antiphospholipid testing - Repeat testing may be required according to diagnostic criteria and timing.
A known chromosome rearrangement in the family - Maternal chromosome analysis may provide useful information.
Recommendation from a fertility, obstetric or haematology specialist - The profile combines several specialist investigations within one pathway.
Recurrent pregnancy loss can have many causes, and normal results from this profile do not exclude anatomical, endocrine, embryonic, paternal or other reproductive factors.
Abnormal findings should be interpreted by an appropriate healthcare professional before treatment or pregnancy-management decisions are made.
How to Prepare
Do not stop anticoagulants, aspirin or other prescribed medication unless the clinician responsible for your care specifically advises you to.
Relevant pregnancy and thrombosis history should be provided so results can be interpreted in context.
How to Book Your Miscarriage Profile Test
The Miscarriage Profile requires several specialist sample types and maternal chromosome analysis, so professional collection is arranged through the appropriate laboratory pathway.
Choose the Miscarriage Profile
Select the renamed £1,438 specialist miscarriage profile.
Select your sample collection option
Arrange an appropriate professional blood collection appointment.
Attend your appointment
The required haematology, coagulation and genetic specimens are collected.
Laboratory analysis
Thrombophilia, antiphospholipid, coagulation and chromosome investigations are processed by the relevant specialist laboratory departments.
Receive your results securely
Your complete authorised report is delivered when all components have been completed.
When Will I Receive My Results?
The specialist laboratory lists an approximate turnaround of 21 days for the complete Miscarriage Profile.
Some routine haematology or coagulation components may become available earlier.
The profile should nevertheless be considered complete only when the specialist chromosome analysis and all other requested tests have been authorised.
Understanding Your Results
Results from this profile should be interpreted as part of a wider recurrent-pregnancy-loss assessment.
An abnormal thrombophilia result does not automatically establish that the abnormality caused a previous miscarriage.
Antiphospholipid syndrome also has specific clinical and laboratory diagnostic requirements and cannot be diagnosed from one isolated antibody result alone.
Chromosome Analysis may identify a balanced or unbalanced chromosome rearrangement that requires specialist genetic interpretation.
A normal profile does not exclude other causes of pregnancy loss.
Further assessment may involve reproductive imaging, endocrine testing, genetic counselling or investigation of the pregnancy tissue or partner depending on the clinical situation.
Why Book With London Blood Tests?
London Blood Tests provides access to a broad specialist laboratory profile for women undergoing investigation following recurrent pregnancy loss.
12 grouped specialist investigations - Haematology, clotting, thrombophilia, antiphospholipid and chromosome testing are combined.
Maternal Chromosome Analysis included - Cytogenetic assessment forms part of the profile.
Inherited thrombophilia markers included - Factor V Leiden and Factor II Prothrombin variants are assessed.
Antiphospholipid testing included - Lupus Anticoagulant and Anticardiolipin Antibodies are included.
Natural anticoagulant proteins assessed - Antithrombin III, Protein C and Free Protein S are measured.
Partner testing can be arranged separately - Partner Chromosome Analysis is not included in the maternal profile and must be requested separately.
Clear pricing - The Miscarriage Profile costs £1,438.
Private Miscarriage Profile Blood Test in London
London Blood Tests provides the private Miscarriage Profile for women undergoing specialist investigation after recurrent pregnancy loss.
The profile costs £1,438 and contains 12 grouped laboratory investigations.
Maternal Chromosome Analysis is included.
The complete profile has an approximate laboratory turnaround of 21 days.